Determinants of IBD-related disability: a cross-sectional survey from the GETAID.

Jenny Tannoury (1) , Maria Nachury (2) , Carole Martins (3) , Melanie Serrero (4) , Jerome Filippi (5) , Xavier Roblin (6) , Anne Bourrier (7) , Guillaume Bouguen (8, 9) , Denis Franchimont (10) , Guillaume Savoye (11, 12, 13, 14) , Anthony Buisson (15) , Edouard Louis (16) , Stephane Nancey (17) , Vered Abitbol (7) , Jean-Marie Reimund (18) , Olivier Dewitt (10) , Lucine Vuitton (19) , Nicolas Mathieu (20) , Laurent Peyrin-Biroulet (21) , Cyrielle Gilletta (22) , Matthieu Allez (7) , Stephanie Viennot (23) , Caroline Trang-Poisson (24) , David Laharie (25) , Aurelien Amiot (1) , Groupe d'Etude Thérapeutique Des Affections Getaid

1 Service d'hépato-gastro-entérologie [APHP Henri Mondor]
2 CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]
3 CHU Clichy
4 CHU Marseille
5 CHU Nice - Centre Hospitalier Universitaire de Nice
6 CHU ST-E - Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne]
7 AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP)
8 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]
9 NuMeCan - Nutrition, Métabolismes et Cancer
10 ULB - Hôpital Erasme [Bruxelles]
11 ADEN - Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau
12 IRIB - Institute for Research and Innovation in Biomedicine
13 Service d'Hépato-Gastroentérologie [CHU Rouen]
14 UNIROUEN UFR Santé - UNIROUEN - UFR Santé
15 CHU Clermont-Ferrand
16 CHU-Liège - Centre Hospitalier Universitaire de Liège
17 CHLS - Centre Hospitalier Lyon Sud [CHU - HCL]
18 CHU Strasbourg - Centre Hospitalier Universitaire [Strasbourg]
19 CHRU Besançon - Centre Hospitalier Régional Universitaire de Besançon
20 CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]
21 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
22 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
23 Service d'Hépato-Gastro-Enterologie et Nutrition [CHU Caen]
24 CHU Nantes - Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
25 CHU Bordeaux

Background: The burden of inflammatory bowel disease (IBD) is rising worldwide. The goal of IBD treatment is to achieve clinical and endoscopic remission but also prevent disability. Aims: To identify the predictive factors of disability in a large population of patients with IBD. Patients and methods: We conducted a cross-sectional survey in 42 tertiary centres in France and Belgium. A self-administered questionnaire was designed to explore patients and their IBD characteristics. IBD-disk is a validated tool to measure disability in patients with IBD. The IBD-disk score was then calculated for each patient. Based on a previous study, an overall IBD-disk score ≥40 was associated with moderate-to-severe disability. Results: Among the 2011 patients, 1700 were analysed, including 746 (44%) in self-reported clinical remission and 752 (44.2%) declaring clinical activity. The patient global assessment of global remission was missing in 200 (11.8%) of 1700 patients. Moderate-to-severe disability was significantly increased in patients with BMI >25 kg/m2 (OR = 1.66; 95% CI [1.29-2.14]), in those having perception of need for a psychotherapist (OR = 2.24; 95% CI [1.79-3.05]) and social worker (OR = 1.54; 95% CI [1.08-2.21]). Conversely, male gender (OR = 0.83; 95% CI [0.69-0.99]), ulcerative colitis (OR = 0.69; 95% CI [0.53-0.92]), self-reported clinical remission (OR = 0.59; 95% CI [0.46-0.77]) and employed or student occupational status (OR = 0.69; 95% CI [0.52-0.92]) were inversely correlated with disability. Overall, 257 (34.5%) patients who declared being in clinical remission had disability. Conclusion: Determinants of IBD-related disability include IBD-related factors but also psychological and social factors. This highlights the importance of a multidisciplinary team in the management of patients with IBD.

Domaines: Hépatologie et Gastroentérologie

Jenny Tannoury, Maria Nachury, Carole Martins, Melanie Serrero, Jerome Filippi, et al.. Determinants of IBD-related disability: a cross-sectional survey from the GETAID.. Alimentary Pharmacology & Therapeutics (Suppl), 2021, 53 (10), pp.1098-1107. ⟨10.1111/apt.16353⟩. ⟨hal-04214710v1⟩