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Amine Directed Palladium Catalyzed C‐H Halogenation of Phenylalanine Derivatives

Abstract : An efficient primary amine-directed palladium catalyzed C-H halogenation (X = I, Br, Cl) of phenylalanine derivatives is reported on a range of quaternary amino acid (AA) derivatives thanks to suited conditions employing trifluoroacetic acid as additive. The extension of this original native functionality-directed ortho-selective halogenation was even demonstrated with the more challenging native phenylalanine as tertiary AA.
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Contributor : Jean-François Brière <>
Submitted on : Thursday, August 19, 2021 - 11:03:06 AM
Last modification on : Friday, August 20, 2021 - 3:25:53 AM


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Alexia Ville, Julien Annibaletto, Sébastien Coufourier, Christophe Hoarau, Rodolphe Tamion, et al.. Amine Directed Palladium Catalyzed C‐H Halogenation of Phenylalanine Derivatives. Chemistry - A European Journal, Wiley-VCH Verlag, In press, ⟨10.1002/chem.202102411⟩. ⟨hal-03322472⟩



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