Amine Directed Palladium Catalyzed C‐H Halogenation of Phenylalanine Derivatives - Normandie Université Access content directly
Journal Articles Chemistry - A European Journal Year : 2021

Amine Directed Palladium Catalyzed C‐H Halogenation of Phenylalanine Derivatives

Abstract

An efficient primary amine-directed palladium catalyzed C-H halogenation (X = I, Br, Cl) of phenylalanine derivatives is reported on a range of quaternary amino acid (AA) derivatives thanks to suited conditions employing trifluoroacetic acid as additive. The extension of this original native functionality-directed ortho-selective halogenation was even demonstrated with the more challenging native phenylalanine as tertiary AA.
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Dates and versions

hal-03322472 , version 1 (19-08-2021)

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Alexia Ville, Julien Annibaletto, Sébastien Coufourier, Christophe Hoarau, Rodolphe Tamion, et al.. Amine Directed Palladium Catalyzed C‐H Halogenation of Phenylalanine Derivatives. Chemistry - A European Journal, In press, 27, pp.13961-13965. ⟨10.1002/chem.202102411⟩. ⟨hal-03322472⟩
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