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Determinants of IBD-related disability: a cross-sectional survey from the GETAID.

Jenny Tannoury 1 Maria Nachury 2 Carole Martins 3 Melanie Serrero 4 Jerome Filippi 5 Xavier Roblin 6 Anne Bourrier 7 Guillaume Bouguen 8, 9 Denis Franchimont 10 Guillaume Savoye 11, 12, 13, 14 Anthony Buisson 15 Edouard Louis 16 Stephane Nancey 17 Vered Abitbol 7 Jean-Marie Reimund 18 Olivier Dewitt 10 Lucine Vuitton 19 Nicolas Mathieu 20 Laurent Peyrin-Biroulet 21 Cyrielle Gilletta 22 Matthieu Allez 7 Stephanie Viennot 23 Caroline Trang-Poisson 24 David Laharie 25 Aurelien Amiot 1, * Groupe d'Etude Thérapeutique Des Affections Getaid
Abstract : Background: The burden of inflammatory bowel disease (IBD) is rising worldwide. The goal of IBD treatment is to achieve clinical and endoscopic remission but also prevent disability. Aims: To identify the predictive factors of disability in a large population of patients with IBD. Patients and methods: We conducted a cross-sectional survey in 42 tertiary centres in France and Belgium. A self-administered questionnaire was designed to explore patients and their IBD characteristics. IBD-disk is a validated tool to measure disability in patients with IBD. The IBD-disk score was then calculated for each patient. Based on a previous study, an overall IBD-disk score ≥40 was associated with moderate-to-severe disability. Results: Among the 2011 patients, 1700 were analysed, including 746 (44%) in self-reported clinical remission and 752 (44.2%) declaring clinical activity. The patient global assessment of global remission was missing in 200 (11.8%) of 1700 patients. Moderate-to-severe disability was significantly increased in patients with BMI >25 kg/m2 (OR = 1.66; 95% CI [1.29-2.14]), in those having perception of need for a psychotherapist (OR = 2.24; 95% CI [1.79-3.05]) and social worker (OR = 1.54; 95% CI [1.08-2.21]). Conversely, male gender (OR = 0.83; 95% CI [0.69-0.99]), ulcerative colitis (OR = 0.69; 95% CI [0.53-0.92]), self-reported clinical remission (OR = 0.59; 95% CI [0.46-0.77]) and employed or student occupational status (OR = 0.69; 95% CI [0.52-0.92]) were inversely correlated with disability. Overall, 257 (34.5%) patients who declared being in clinical remission had disability. Conclusion: Determinants of IBD-related disability include IBD-related factors but also psychological and social factors. This highlights the importance of a multidisciplinary team in the management of patients with IBD.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-03216615
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Submitted on : Tuesday, May 4, 2021 - 11:09:25 AM
Last modification on : Sunday, May 1, 2022 - 3:17:20 AM

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Jenny Tannoury, Maria Nachury, Carole Martins, Melanie Serrero, Jerome Filippi, et al.. Determinants of IBD-related disability: a cross-sectional survey from the GETAID.. Alimentary Pharmacology & Therapeutics (Suppl), 2021, 53 (10), pp.1098-1107. ⟨10.1111/apt.16353⟩. ⟨hal-03216615⟩

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