Linkage Mapping of the [Pro 2 ]Somatostatin-14 Gene in Zebrafish: Evolutionary Perspectives

Hervé Tostivint (1) , Lucille Joly (2) , Isabelle Lihrmann (1) , J Michael Conlon (3) , Marc Ekker (2) , Hubert Vaudry (1)

1 Neuroendocrinologie cellulaire et moléculaire
2 University of Ottawa [Ottawa]
3 UAEU - United Arab Emirates University

Radiation hybrid mapping assigned the zebrafish [Pro(2)]somatostatin-14 (also termed somatostatin 2; SS2) gene to linkage group 23 of the zebrafish genome, close to the marker nadl1.2. Comparative genomic analysis revealed conserved syntenies of the SS2 gene locus with part of the human 1p36 region, where the cortistatin gene is located. This observation strongly suggests that the SS2 gene in nonmammalian species and the cortistatin gene in mammals are orthologous.

Keywords: somatostatin; cortistatin; zebrafish; radiation hybrid mapping; comparative genomics; evolution

Domains: Life Sciences [q-bio]; Biochemistry, Molecular Biology; Subcellular Processes [q-bio.SC]

Hervé Tostivint, Lucille Joly, Isabelle Lihrmann, J Michael Conlon, Marc Ekker, et al.. Linkage Mapping of the [Pro 2 ]Somatostatin-14 Gene in Zebrafish: Evolutionary Perspectives. Annals of the New York Academy of Sciences, 2005, 1040 (1), pp.486-489. ⟨10.1196/annals.1327.098⟩. ⟨hal-02427133⟩