Palladium-catalyzed carbonylative cross-coupling reactions of pyridine halides and aryl boronic acids: a convenient access to α-pyridyl ketones

Samuel Couve-Bonnaire (1) , Jean-François Carpentier (1) , Andre Mortreux (1) , Yves Castanet (1)

1 UCCS - Unité de Catalyse et Chimie du Solide - UMR 8181

The proper choice of solvent, catalyst precursor and CO pressure enables the easy and selective transformation of mono- and dihalopyridines into phenyl pyridyl ketones in 81–95% yields. The proper choice of solvent, catalyst precursor and CO pressure enables the facile and selective transformation of mono- and dihalopyridines into phenyl pyridyl ketones.

Keywords: ketones; palladium; pyridines; carbonylation; cross-coupling

Domains: Catalysis; Coordination chemistry; Inorganic chemistry; Organic chemistry; Theoretical and/or physical chemistry; Chemical Sciences; Biochemistry, Molecular Biology; Cancer; Life Sciences [q-bio]

Samuel Couve-Bonnaire, Jean-François Carpentier, Andre Mortreux, Yves Castanet. Palladium-catalyzed carbonylative cross-coupling reactions of pyridine halides and aryl boronic acids: a convenient access to α-pyridyl ketones. Tetrahedron Letters, 2001, 42 (22), pp.3689-3691. ⟨10.1016/S0040-4039(01)00544-5⟩. ⟨hal-02384503⟩