Modulation of intermolecular interactions in new pyrimidine–porphyrin system as two-photon absorbing photosensitizers

Ahmad Jiblaoui (1) , Julien Brevier (1) , Guillaume Ducourthial (1) , Hector Gonzalez-Nunez (2) , Christine Baudequin (3) , Vincent Sol (1) , Stéphanie Leroy-Lhez (1)

1 UNILIM - Université de Limoges
2 USC - Universidade de Santiago de Compostela [Spain]
3 COBRA - Chimie Organique et Bioorganique : Réactivité et Analyse

New porphyrins–pyrimidine systems have been synthesized for photodynamic therapy applications. Indeed, such association through acetylenic bond should improve two-photon absorption properties. As expected an intermolecular interaction between photosensitizers has been observed but more surprisingly it seems to favor two-photon absorption.

Mots clés: Porphyrin; Pyrimidine; Photodynamic therapy; Two-photon absorption; Intramolecular interaction

Domaines: Catalyse; Chimie organique; Matériaux

Ahmad Jiblaoui, Julien Brevier, Guillaume Ducourthial, Hector Gonzalez-Nunez, Christine Baudequin, et al.. Modulation of intermolecular interactions in new pyrimidine–porphyrin system as two-photon absorbing photosensitizers. Tetrahedron, 2015, 71 (16), pp.2428-2434. ⟨10.1016/j.tet.2015.02.068⟩. ⟨hal-02381719⟩