Receptor Activator of NF-κB Orchestrates Activation of Antiviral Memory CD8 T Cells in the Spleen Marginal Zone

Abstract : Graphical Abstract Highlights d RANK deletion does not affect DC survival or T cell priming in the context of infection d RANK is required for memory CD8 T cell activation in response to viral infection d RANK-dependent CD169 + macrophages support viral replication in the spleen marginal zone d RANK expression in DCs promotes the recruitment and activation of memory CD8 T cells In Brief Habbeddine et al. show that RANK signaling in the spleen marginal zone plays an important role in orchestrating protective immune responses to viral infection. They show that RANK expressed by macrophages supports viral replication, while RANK signaling in dendritic cells promotes the recruitment and activation of memory CD8 T cells.