Receptor Activator of NF-κB Orchestrates Activation of Antiviral Memory CD8 T Cells in the Spleen Marginal Zone

Mohamed Habbeddine (1) , Christophe Verthuy (2) , Olivia Rastoin , Lionel Chasson (2) , Magali Bebien (3) , Marc Bajenoff (2) , Sahil Adriouch (4) , Joke M.M. den Haan , Josef Penninger (5) , Toby Lawrence (2)

1 IJM (UMR_7592) - Institut Jacques Monod
2 CIML - Centre d'Immunologie de Marseille - Luminy
3 Kennedy Institute of Rheumatology
4 Physiopathologie et biothérapies des maladies inflammatoires et autoimmunes
5 Institute of Molecular Biotechnology

Graphical Abstract Highlights d RANK deletion does not affect DC survival or T cell priming in the context of infection d RANK is required for memory CD8 T cell activation in response to viral infection d RANK-dependent CD169 + macrophages support viral replication in the spleen marginal zone d RANK expression in DCs promotes the recruitment and activation of memory CD8 T cells In Brief Habbeddine et al. show that RANK signaling in the spleen marginal zone plays an important role in orchestrating protective immune responses to viral infection. They show that RANK expressed by macrophages supports viral replication, while RANK signaling in dendritic cells promotes the recruitment and activation of memory CD8 T cells.

Domains: Immunology

Mohamed Habbeddine, Christophe Verthuy, Olivia Rastoin, Lionel Chasson, Magali Bebien, et al.. Receptor Activator of NF-κB Orchestrates Activation of Antiviral Memory CD8 T Cells in the Spleen Marginal Zone. Cell Reports, 2017, 21 (9), pp.2515-2527. ⟨10.1016/j.celrep.2017.10.111⟩. ⟨hal-02376107⟩