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Journal Articles Bioconjugate Chemistry Year : 2009

Antibacterial and Antifouling Polymer Brushes Incorporating Antimicrobial Peptide

Endogenous Expression of ODN-Related Peptides in Astrocytes Contributes to Cell Protection Against Oxidative Stress: Astrocyte-Neuron Crosstalk Relevance for Neuronal Survival.

Fabrice Morin
  • Function : Author
Pierre Michael Coly
  • Function : Author
Marie-Laure Walet-Balieu
Sami Zekri
  • Function : Author
Hélène Castel
Olfa Masmoudi-Kouki
  • Function : Author
  • PersonId : 976009
Alain Jonas
  • Function : Author
Thierry Jouenne
Wilhelm Huck
  • Function : Author

Abstract

Surface-initiated atom transfer radical polymerization (ATRP) has been used to prepare antifouling copolymer brushes based on 2-(2-methoxyethoxy)ethyl methacrylate (MEO(2)MA) and hydroxyl-terminated oligo(ethylene glycol) methacrylate (HOEGMA). The amount of hydroxyl reactive groups incorporated into the brushes was varied by changing the composition of the monomer mixture. These coatings were subsequently functionalized by a natural antibacterial peptide, magainin I, via an oriented chemical grafting on hydroxyl groups, which maintains the activity of the peptide. The antibacterial activity of the functionalized brushes was successfully tested against two different strains of gram-positive bacteria.
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Dates and versions

hal-01962743 , version 1 (20-12-2018)

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Ikram Ghouili, Seyma Bahdoudi, Fabrice Morin, Fatma Amri, Yosra Hamdi, et al.. Antibacterial and Antifouling Polymer Brushes Incorporating Antimicrobial Peptide. Bioconjugate Chemistry, 2009, 20 (1), pp.71-77. ⟨10.1021/bc800280u⟩. ⟨hal-01962743⟩
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