Fusion-negative rhabdomyosarcoma 3D organoids to predict effective drug combinations: A proof-of-concept on cell death inducers

Clara Savary (1) , Léa Luciana (1) , Paul Huchedé (1) , Arthur Tourbez (1) , Claire Coquet (1) , Maëlle Broustal (1) , Alejandro Lopez Gonzalez (1) , Clémence Deligne (1) , Thomas Diot (1) , Olivier Naret , Mariana Costa , Nina Meynard (1) , Virginie Barbet (1) , Kevin Müller (1) , Laurie Tonon (2) , Nicolas Gadot (2) , Cyril Degletagne (2) , Valéry Attignon (2) , Sophie Léon (2) , Christophe Vanbelle (2) , Alexandra Bomane (2) , Isabelle Rochet (3, 4) , Virginie Mournetas (5) , Luciana Oliveira (5) , Paul Rinaudo (5) , Christophe Bergeron (3) , Aurélie Dutour (2) , Martine Cordier-Bussat (2) , Aline Roch , Nathalie Brandenberg , Sophie El Zein (6) , Sarah Watson (7, 6) , Daniel Orbach (6) , Olivier Delattre (7, 6) , Frédérique Dijoud (4) , Nadège Corradini (3, 1) , Cécile Picard (4) , Delphine Maucort-Boulch (8, 9, 10) , Marion Le Grand (1) , Eddy Pasquier (1) , Jean-Yves Blay (2, 11) , Marie Castets (2) , Laura Broutier (2)

1 CRCM - Centre de Recherche en Cancérologie de Marseille
2 UNICANCER/CRCL - Centre de Recherche en Cancérologie de Lyon
3 IHOPe - Institut d'hématologie et d'oncologie pédiatrique [CHU - HCL]
4 HFME - Hôpital Femme Mère Enfant [CHU - HCL]
5 ADLIN Science
6 Institut Curie [Paris]
7 U830 - Unité de génétique et biologie des cancers
8 LBBE - Laboratoire de Biométrie et Biologie Evolutive - UMR 5558
9 HCL - Hospices Civils de Lyon
10 Service de Biostatistiques [Lyon]
11 Centre Léon Bérard [Lyon]

Highlights d Relapsed rhabdomyosarcoma (RMS) 3D organoids can be derived from needle biopsies d RMS 3D organoids finely preserve inter-and intra-tumor heterogeneity d Transcriptomic approach reveals Survivin as a key apoptosis blockage point in RMS d RMS 3D organoids are powerful tools to design and/or reexplore drug combinations Authors

Domains: Cancer

Clara Savary, Léa Luciana, Paul Huchedé, Arthur Tourbez, Claire Coquet, et al.. Fusion-negative rhabdomyosarcoma 3D organoids to predict effective drug combinations: A proof-of-concept on cell death inducers. Cell Reports Medicine, 2023, 4, ⟨10.1016/j.xcrm.2023.101339⟩. ⟨hal-04374201⟩