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Theses

Epidémiologie moléculaire des virus dans les voies respiratoires et association avec les signes cliniques d’asthme équin modéré

Abstract : Equine influenza virus (EIV), α-herpesvirus (EHV-1 & EHV-4), Equine rhinitis virus A and B (ERAV & ERBV), Equine adenovirus 1 and 2 (EAdV1 & EAdV2) Herpesvirus (EHV-2 & EHV-5) and Equine coronavirus (ECoV)) are not currently being investigated by qPCR for mild equine asthma (MEA) in training horses. The objectives of this project are to: 1) determine the prevalence and incidence of viral genome detection and / or quantification in the respiratory tract of racehorses during training; 2) to study the concordance between two compartments of the respiratory tract; 3) specify the relationship between detection and / or viral quantification and a) the clinical signs of MEA and b) performance. A longitudinal prospective study was conducted from November 2012 to January 2015, both nasopharyngeal swabs (NS) and tracheal washes (TW) were collected monthly on 52 Strandardbred racehorses at training. The ten viruses of interest were systematically investigated by qPCR in NS and TW. Clinical signs of MEA (nasal discharge, cough) and tracheal mucus score were noted during each examination. The viral genomes most frequently detected in NS and TW are EHV-5, EHV-2 and ERBV. No significant association was found between viral detection / quantification in NS and clinical signs. Detection of EHV-2 in TW was significantly associated with cough (OR 3. 1, P = 0. 01) and excess tracheal mucus (OR 2. 1, P = 0. 02). Detection (OR 5. 3; P <0. 001) and quantification of ERBV (OR 15. 0; P <0. 001) in LT were significantly associated with cough.
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https://hal-normandie-univ.archives-ouvertes.fr/tel-02946554
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Submitted on : Wednesday, September 23, 2020 - 11:30:25 AM
Last modification on : Wednesday, October 14, 2020 - 4:14:41 AM

Identifiers

  • HAL Id : tel-02946554, version 1

Citation

Nadia Doubli-Bounoua. Epidémiologie moléculaire des virus dans les voies respiratoires et association avec les signes cliniques d’asthme équin modéré. Médecine vétérinaire et santé animale. Université de Caen Normandie, 2016. Français. ⟨tel-02946554⟩

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