. I. Ii and . B-|-gtpase-de-la-famille,

. Ii and . Iii, C | Régulation de la transcription et localisation nucléaire __________________________________ 76

, | Récepteurs métabotropiques du glutamate _______________________________________ 81 II.III.D.2 | Calcium sensing receptor _____________________________________________________ 82 II.III.D.3 | Récepteurs chimiotactiques ___________________________________________________ 83 II.III.D.4 | Récepteurs opioïdergiques ____________________________________________________ 84 II.III.D.5 | Récepteurs dopaminergiques __________________________________________________ 85 II.III.D.6 | Récepteurs calcitoninergiques _________________________________________________ 86 II.III.D.7 | Récepteurs somatostatinergique _______________________________________________ 86 II

R. Agnihotri, S. Burrell, K. E. Wolf, A. Jalali, S. Hawkins et al., Glioblastoma, a brief review of history, molecular genetics, animal models and novel therapeutic strategies, Arch Immunol Ther Exp (Warsz), vol.61, issue.1, pp.25-41, 2013.

Ö. Alper, W. G. Stetler-stevenson, L. N. Harris, W. W. Leitner, M. Özdemirli et al., Novel anti-filamin-A antibody detects a secreted variant of filamin-A in plasma from patients with breast carcinoma and high-grade astrocytoma, Cancer Science, 2009.

M. Aubry, M. De-tayrac, A. Etcheverry, A. Clavreul, S. Saikali et al., From the core to beyond the margin: a genomic picture of glioblastoma intratumor heterogeneity, Oncotarget, vol.6, issue.14, pp.12094-12109, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01396745

M. A. Ayoub, E. Trinquet, K. Pfleger, and J. Pin, Differential association modes of the thrombin receptor PAR 1 with G?i1, G?12, and ?-arrestin 1, The FASEB Journal, vol.24, issue.9, pp.3522-3535, 2010.

R. Bayat-mokhtari, T. S. Homayouni, N. Baluch, E. Morgatskaya, S. Kumar et al., Combination therapy in combating cancer, Oncotarget, vol.8, issue.23, pp.38022-38043, 2017.

D. Bhandari, S. L. Robia, and A. Marchese, The E3 ubiquitin ligase atrophin interacting protein 4 binds directly to the chemokine receptor CXCR4 via a novel WW domain-mediated interaction, Mol Biol Cell, vol.20, issue.5, pp.1324-1339, 2009.

P. Birner, A. Tchorbanov, S. Natchev, J. Tuettenberg, and M. Guentchev, The chemokine receptor CXCR7 influences prognosis in human glioma in an IDH1-dependent manner, Journal of Clinical Pathology, vol.68, issue.10, pp.830-834, 2015.

C. Brulé, N. Perzo, J. Joubert, X. Sainsily, R. Leduc et al., Biased signaling regulates the pleiotropic effects of the urotensin II receptor to modulate its cellular behaviors, The FASEB Journal, vol.28, issue.12, pp.5148-5162, 2014.

D. A. Calderwood, A. Huttenlocher, W. B. Kiosses, D. M. Rose, D. G. Woodside et al., Increased filamin binding to ?-integrin cytoplasmic domains inhibits cell migration, Nature Cell Biology, vol.3, issue.12, pp.1060-1068, 2001.

D. A. Calderwood, S. J. Shattil, and M. H. Ginsberg, Integrins and Actin Filaments: Reciprocal Regulation of Cell Adhesion and Signaling, Journal of Biological Chemistry, vol.275, issue.30, pp.22607-22610, 2000.

C. Voituriez and R. , Actin flows in cell migration: from locomotion and polarity to trajectories, Current Opinion in Cell Biology, vol.38, pp.12-17, 2016.

M. S. Carro, W. K. Lim, M. J. Alvarez, R. J. Bollo, X. Zhao et al., The transcriptional network for mesenchymal transformation of brain tumours, Nature, vol.463, issue.7279, pp.318-325, 2010.

H. Castel, L. Desrues, J. Joubert, M. Tonon, L. Prézeau et al.,

, The G Protein-Coupled Receptor UT of the Neuropeptide Urotensin II Displays Structural and Functional Chemokine Features, Front Endocrinol, vol.8

S. Civciristov, A. M. Ellisdon, R. Suderman, C. K. Pon, B. A. Evans et al., Preassembled GPCR signaling complexes mediate distinct cellular responses to ultralow ligand concentrations, Science Signaling, vol.11, issue.551, p.1188, 2018.

C. A. Clara, S. Marie, J. Almeida, . De, A. Wakamatsu et al., Angiogenesis and expression of PDGF-C, VEGF, CD105 and HIF-1? in human glioblastoma, Neuropathology, vol.34, issue.4, pp.343-352, 2014.

P. Coly, N. Perzo, L. Joncour, V. Lecointre, C. Schouft et al., Chemotactic G protein-coupled receptors control cell migration by repressing autophagosome biogenesis, Autophagy, vol.12, issue.12, pp.2344-2362, 2016.
URL : https://hal.archives-ouvertes.fr/hal-02345740

L. Cooper, D. A. Gutman, C. Chisolm, C. Appin, J. Kong et al., The Tumor Microenvironment Strongly Impacts Master Transcriptional Regulators and Gene Expression Class of Glioblastoma, The American Journal of Pathology, vol.180, issue.5, pp.2108-2119, 2012.

I. H. Cukier, Y. Li, and J. M. Lee, Cyclin B1/Cdk1 binds and phosphorylates Filamin A and regulates its ability to cross-link actin, FEBS Letters, vol.581, issue.8, pp.1661-1672, 2007.

C. C. Cunningham, J. B. Gorlin, D. J. Kwiatkowski, J. H. Hartwig, P. A. Janmey et al., Actin-binding protein requirement for cortical stability and efficient locomotion, Science, vol.255, issue.5042, pp.325-327, 1992.

I. Desbaillets, A. C. Diserens, N. Tribolet, M. F. Hamou, V. Meir et al., Upregulation of interleukin 8 by oxygen-deprived cells in glioblastoma suggests a role in leukocyte activation, chemotaxis, and angiogenesis, J Exp Med, vol.186, issue.8, pp.1201-1212, 1997.

P. Dillenburg-pilla, V. Patel, C. M. Mikelis, C. R. Zárate-bladés, C. L. Doçi et al., SDF-1/CXCL12 induces directional cell migration and spontaneous metastasis via a CXCR4/G ? i/mTORC1 axis, The FASEB Journal, vol.29, issue.3, pp.1056-1068, 2015.

C. Eckerich, S. Zapf, R. Fillbrandt, S. Loges, M. Westphal et al., Hypoxia can induce c-Met expression in glioma cells and enhance SF/HGF-induced cell migration, Int J Cancer, vol.121, issue.2, pp.276-283, 2007.

M. Ehtesham, J. A. Winston, P. Kabos, and R. C. Thompson, CXCR4 expression mediates glioma cell invasiveness, Oncogene, vol.25, pp.2801-2806, 2006.

A. C. Epstein, J. M. Gleadle, L. A. Mcneill, K. S. Hewitson, J. O'rourke et al., C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation, Cell, vol.107, issue.1, pp.43-54, 2001.
URL : https://hal.archives-ouvertes.fr/in2p3-00023372

M. Esencay, Y. Sarfraz, and D. Zagzag, CXCR7 is induced by hypoxia and mediates glioma cell migration towards SDF-1?, BMC Cancer, vol.13, issue.1, 2013.

G. Esposito, C. Perrino, A. Cannavo, G. G. Schiattarella, F. Borgia et al., EGFR trans-activation by urotensin II receptor is mediated by ?-arrestin recruitment and confers cardioprotection in pressure overloadinduced cardiac hypertrophy, Basic Res Cardiol, vol.106, issue.4, pp.577-589, 2011.

A. Federico, S. Zappavigna, M. Romano, P. Grieco, A. Luce et al., Urotensin-II receptor is over-expressed in colon cancer cell lines and in colon carcinoma in humans, European Journal of Clinical Investigation, vol.44, issue.3, pp.285-294, 2014.

Y. Feng, M. H. Chen, I. P. Moskowitz, A. M. Mendonza, L. Vidali et al., Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis, PNAS, vol.103, issue.52, pp.19836-19841, 2006.

A. Giese, R. Bjerkvig, M. E. Berens, and M. Westphal, Cost of Migration: Invasion of Malignant Gliomas and Implications for Treatment, Journal of Clinical Oncology, 2016.

R. J. Giger, K. Venkatesh, O. Chivatakarn, S. J. Raiker, L. Robak et al., Mechanisms of CNS myelin inhibition: evidence for distinct and neuronal cell type specific receptor systems, Restor Neurol Neurosci, vol.26, issue.2-3, pp.97-115, 2008.

D. L. Gillespie, K. Whang, B. T. Ragel, J. R. Flynn, D. A. Kelly et al., Silencing of Hypoxia Inducible Factor-1? by RNA Interference Attenuates Human Glioma Cell Growth In vivo, Clin Cancer Res, vol.13, issue.8, pp.2441-2448, 2007.

M. C. Gingras, E. Roussel, J. M. Bruner, C. D. Branch, R. P. Moser et al., Comparison of cell adhesion molecule expression between glioblastoma multiforme and autologous normal brain tissue, J Neuroimmunol, vol.57, issue.1-2, pp.1089-105, 1990.

P. Grieco, R. Franco, G. Bozzuto, L. Toccacieli, A. Sgambato et al., Urotensin II receptor predicts the clinical outcome of prostate cancer patients and is involved in the regulation of motility of prostate adenocarcinoma cells, J Cell Biochem, vol.112, issue.1, pp.341-353, 2011.

P. G. Gritsenko, O. Ilina, and P. Friedl, Interstitial guidance of cancer invasion, The Journal of Pathology, vol.226, issue.2, pp.185-199, 2012.

C. Guo, C. Liang, J. Yang, H. Hu, B. Fan et al., LATS2 inhibits cell proliferation and metastasis through the Hippo signaling pathway in glioma, Oncol Rep, vol.41, issue.5, pp.2753-2761, 2019.

A. C. Hanyaloglu, M. Zastrow, and . Von, Regulation of GPCRs by Endocytic Membrane Trafficking and Its Potential Implications, Annual Review of Pharmacology and Toxicology, vol.48, issue.1, pp.537-568, 2008.

X. Hong, F. Jiang, S. N. Kalkanis, Z. G. Zhang, X. Zhang et al., SDF-1 and CXCR4 are up-regulated by VEGF and contribute to glioma cell invasion, Cancer Lett, vol.236, issue.1, pp.39-45, 2006.

S. S. Ithychanda, D. Hsu, H. Li, L. Yan, D. Liu et al., Identification and Characterization of Multiple Similar Ligand-binding Repeats in Filamin: implication on filamin-mediated receptor clustering and cross-talk, Journal of Biological Chemistry, vol.284, issue.50, pp.35113-35121, 2009.

M. Ivan, K. Kondo, H. Yang, W. Kim, J. Valiando et al., HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing, Science, vol.292, issue.5516, pp.464-468, 2001.

R. K. Jain, Molecular regulation of vessel maturation, Nat Med, vol.9, issue.6, pp.685-693, 2003.

E. P. Jane, D. R. Premkumar, J. M. Cavaleri, P. A. Sutera, T. Rajasekar et al., Dinaciclib, a Cyclin-Dependent Kinase Inhibitor Promotes Proteasomal Degradation of Mcl-1 and Enhances ABT-737-Mediated Cell Death in Malignant Human Glioma Cell Lines, J Pharmacol Exp Ther, vol.356, issue.2, pp.354-365, 2016.

F. Jean-alphonse and A. C. Hanyaloglu, Regulation of GPCR signal networks via membrane trafficking, Molecular and Cellular Endocrinology, vol.331, issue.2, pp.205-214, 2011.
URL : https://hal.archives-ouvertes.fr/hal-00654486

X. Jiang, J. Yue, H. Lu, N. Campbell, Q. Yang et al., Inhibition of Filamin-A Reduces Cancer Metastatic Potential, Int J Biol Sci, vol.9, issue.1, pp.67-77, 2012.

S. Jiménez-baranda, C. Gómez-moutón, A. Rojas, L. Martínez-prats, M. E. et al., Filamin-A regulates actindependent clustering of HIV receptors, Nature Cell Biology, vol.9, issue.7, pp.838-846, 2007.

R. Kalluri, Basement membranes: structure, assembly and role in tumour angiogenesis, Nature Reviews Cancer, vol.3, issue.6, pp.422-433, 2003.

C. M. Kenific, T. Wittmann, and J. Debnath, Autophagy in adhesion and migration, J Cell Sci, vol.129, issue.20, pp.3685-3693, 2016.

V. G. Keshamouni, G. Michailidis, C. S. Grasso, S. Anthwal, J. R. Strahler et al., Differential protein expression profiling by iTRAQ-2DLC-MS/MS of lung cancer cells undergoing epithelialmesenchymal transition reveals a migratory/invasive phenotype, J Proteome Res, vol.5, issue.5, pp.1143-1154, 2006.

T. Kiema, Y. Lad, P. Jiang, C. L. Oxley, M. Baldassarre et al., The Molecular Basis of Filamin Binding to Integrins and Competition with Talin, Molecular Cell, vol.21, issue.3, pp.337-347, 2006.

H. Kim, F. Nakamura, W. Lee, C. Hong, D. Pérez-sala et al., Regulation of cell adhesion to collagen via ?1 integrins is dependent on interactions of filamin A with vimentin and protein kinase C epsilon, Experimental Cell Research, vol.316, issue.11, pp.1829-1844, 2010.

K. Kim, R. R. Gainetdinov, S. A. Laporte, M. G. Caron, and L. S. Barak, G Protein-coupled Receptor Kinase Regulates Dopamine D3 Receptor Signaling by Modulating the Stability of a Receptor-Filamin-?-Arrestin Complex A CASE OF AUTORECEPTOR REGULATION, J Biol Chem, vol.280, issue.13, pp.12774-12780, 2005.

P. Koivunen, S. M. Fell, W. Lu, J. D. Rabinowitz, A. L. Kung et al., The 2-oxoglutarate analog 3-oxoglutarate decreases normoxic hypoxia-inducible factor-1? in cancer cells, induces cell death, and reduces tumor xenograft growth, Hypoxia (Auckl), vol.4, pp.15-27, 2016.

W. H. Koppenol, P. L. Bounds, and C. V. Dang, Otto Warburg's contributions to current concepts of cancer metabolism, Nat Rev Cancer, vol.11, issue.5, pp.325-337, 2011.

M. Koshy, J. L. Villano, T. A. Dolecek, A. Howard, U. Mahmood et al., Improved survival time trends for glioblastoma using the SEER 17 population-based registries, J Neurooncol, vol.107, issue.1, pp.207-212, 2012.

J. Kouno, H. Nagai, T. Nagahata, M. Onda, H. Yamaguchi et al., Up-regulation of CC chemokine, CCL3L1, and receptors, CCR3, CCR5 in human glioblastoma that promotes cell growth, J Neurooncol, vol.70, issue.3, pp.301-307, 2004.

Y. Lad, P. Jiang, S. Ruskamo, D. S. Harburger, J. Ylänne et al., Structural Basis of the Migfilin-Filamin Interaction and Competition with Integrin ? Tails, J Biol Chem, vol.283, issue.50, pp.35154-35163, 2008.

S. S. Lakka, C. S. Gondi, N. Yanamandra, W. C. Olivero, D. H. Dinh et al., Inhibition of cathepsin B and MMP-9 gene expression in glioblastoma cell line via RNA interference reduces tumor cell invasion, tumor growth and angiogenesis, Oncogene, vol.23, issue.27, pp.4681-4689, 2004.

F. Lange, D. Kaemmerer, J. Behnke-mursch, W. Brück, S. Schulz et al., Differential somatostatin, CXCR4 chemokine and endothelin A receptor expression in WHO grade I-IV astrocytic brain tumors, Journal of Cancer Research and Clinical Oncology, 2018.

C. Lecointre, L. Desrues, J. E. Joubert, N. Perzo, P. Guichet et al., Signaling switch of the urotensin II vasosactive peptide GPCR: prototypic chemotaxic mechanism in glioma, Oncogene, vol.34, issue.39, pp.5080-5094, 2015.
URL : https://hal.archives-ouvertes.fr/hal-02367872

Y. Liang, A. W. Bollen, and N. Gupta, CC chemokine receptor-2A is frequently overexpressed in glioblastoma, J Neurooncol, vol.86, issue.2, pp.153-163, 2008.

R. Lin, K. Karpa, N. Kabbani, P. Goldman-rakic, and R. Levenson, Dopamine D2 and D3 receptors are linked to the actin cytoskeleton via interaction with filamin A, Proc Natl Acad Sci U S A, vol.98, issue.9, pp.5258-5263, 2001.

G. Liu, L. Thomas, R. A. Warren, C. A. Enns, C. C. Cunningham et al., Cytoskeletal Protein ABP-280 Directs the Intracellular Trafficking of Furin and Modulates Proprotein Processing in the Endocytic Pathway, J Cell Biol, vol.139, issue.7, pp.1719-1733, 1997.

Y. Liu, E. Carson-walter, and K. A. Walter, Targeting Chemokine Receptor CXCR7 Inhibits Glioma Cell Proliferation and Mobility, Anticancer Res, vol.35, issue.1, pp.53-64, 2015.

Y. Liu, L. Berre, M. Lautenschlaeger, F. Maiuri, P. et al., Confinement and Low Adhesion Induce Fast Amoeboid Migration of Slow Mesenchymal Cells, Cell, vol.160, issue.4, pp.659-672, 2015.

D. N. Louis, H. Ohgaki, O. D. Wiestler, W. K. Cavenee, P. C. Burger et al., The 2007 WHO Classification of Tumours of the Central Nervous System, Acta Neuropathologica, vol.114, issue.2, pp.97-109, 2007.

D. N. Louis, A. Perry, G. Reifenberger, A. Von-deimling, D. Figarella-branger et al., The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary, Acta Neuropathologica, vol.131, issue.6, pp.803-820, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01479018

D. Lubanska and L. Porter, Revisiting CDK Inhibitors for Treatment of Glioblastoma Multiforme, Drugs R D, vol.17, issue.2, pp.255-263, 2017.

S. Lv, E. Teugels, J. Sadones, E. Quartier, M. Huylebrouck et al., Correlation between IDH1 Gene Mutation Status and Survival of Patients Treated for Recurrent Glioma, Anticancer Res, vol.31, issue.12, pp.4457-4463, 2011.

K. Maehara, K. Takahashi, and S. Saitoh, CENP-A reduction induces a p53-dependent cellular senescence response to protect cells from executing defective mitoses, Mol Cell Biol, vol.30, issue.9, pp.2090-2104, 2010.

S. Merighi, A. Benini, P. Mirandola, S. Gessi, K. Varani et al., Adenosine modulates vascular endothelial growth factor expression via hypoxiainducible factor-1 in human glioblastoma cells, Biochem Pharmacol, vol.72, issue.1, pp.19-31, 2006.

S. C. Meyer, S. Zuerbig, C. C. Cunningham, J. H. Hartwig, T. Bissell et al., Identification of the Region in Actin-binding Protein that Binds to the Cytoplasmic Domain of Glycoprotein Ib?, J Biol Chem, vol.272, issue.5, pp.2914-2919, 1997.

S. Minina, M. Reichman-fried, and R. E. , Control of Receptor Internalization, Signaling Level, and Precise Arrival at the Target in Guided Cell Migration, Current Biology, vol.17, issue.13, pp.1164-1172, 2007.

L. Minsaas, J. Planagumà, M. Madziva, B. F. Krakstad, M. Masià-balagué et al.,

, Filamin A Binds to CCR2B and Regulates Its Internalization, PLOS ONE, vol.5, issue.8, p.12212

T. Miyazaki, Y. Uemae, and E. Ishikawa, CXCL12/CXCR4 signaling in glioma stem cellsprospects for therapeutic intervention, Translational Cancer Research, vol.6, issue.2, pp.434-437, 2017.

S. Najib, N. Saint-laurent, J. Estève, S. Schulz, E. Boutet-robinet et al., A Switch of G Protein-Coupled Receptor Binding Preference from Phosphoinositide 3-Kinase (PI3K)-p85 to Filamin A Negatively Controls the PI3K Pathway, Molecular and Cellular Biology, vol.32, issue.5, pp.1004-1016, 2012.

F. Nakamura, J. H. Hartwig, T. P. Stossel, and P. T. Szymanski, Ca 2+ and Calmodulin Regulate the Binding of Filamin A to Actin Filaments, Journal of Biological Chemistry, vol.280, issue.37, pp.32426-32433, 2005.

F. Nakamura, T. P. Stossel, and J. H. Hartwig, The filamins: Organizers of cell structure and function, Cell Adhesion & Migration, vol.5, issue.2, pp.160-169, 2011.

N. Naslavsky and S. Caplan, The enigmatic endosome -sorting the ins and outs of endocytic trafficking, J Cell Sci, vol.131, issue.13, 2018.

Y. Ohta, N. Suzuki, S. Nakamura, J. H. Hartwig, and T. P. Stossel, The small GTPase RalA targets filamin to induce filopodia, Proc Natl Acad Sci U S A, vol.96, issue.5, pp.2122-2128, 1999.

I. Onoprishvili, Interaction Between the Opioid Receptor and Filamin A Is Involved in Receptor Regulation and Trafficking, Molecular Pharmacology, vol.64, issue.5, pp.1092-1100, 2003.

Q. T. Ostrom, H. Gittleman, P. Liao, C. Rouse, Y. Chen et al., CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in, Neuro-oncology, vol.16, pp.1-63, 2007.

X. Pang, Q. Bai, F. Wu, G. Chen, A. Zhang et al., Urotensin II Induces ER Stress and EMT and Increase Extracellular Matrix Production in Renal Tubular Epithelial Cell in Early Diabetic Mice, KBR, vol.41, issue.4, pp.434-449, 2016.

A. P. Patel, I. Tirosh, J. J. Trombetta, A. K. Shalek, S. M. Gillespie et al., Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma, Science, vol.344, issue.6190, pp.1396-1401, 2014.

W. Paulus, I. Baur, D. Schuppan, and W. Roggendorf, Characterization of integrin receptors in normal and neoplastic human brain, Am J Pathol, vol.143, issue.1, pp.154-163, 1993.

U. Pentikäinen, P. Jiang, H. Takala, S. Ruskamo, I. D. Campbell et al., Assembly of a Filamin Four-domain Fragment and the Influence of Splicing Variant-1 on the Structure, J Biol Chem, vol.286, issue.30, pp.26921-26930, 2011.

E. Peverelli, E. Giardino, D. Treppiedi, E. Vitali, V. Cambiaghi et al., Filamin A (FLNA) Plays an Essential Role in Somatostatin Receptor 2 (SST2) Signaling and Stabilization After Agonist Stimulation in Human and Rat Somatotroph Tumor Cells, Endocrinology, vol.155, issue.8, pp.2932-2941, 2014.

E. Peverelli, E. Giardino, E. Vitali, D. Treppiedi, A. G. Lania et al., Filamin A in Somatostatin and Dopamine Receptor Regulation in Pituitary and the Role of cAMP/PKA Dependent Phosphorylation, Horm Metab Res, vol.46, issue.12, pp.845-853, 2014.

K. Pham, D. Luo, D. W. Siemann, B. K. Law, B. A. Reynolds et al., VEGFR inhibitors upregulate CXCR4 in VEGF receptor-expressing glioblastoma in a TGF?R signaling-dependent manner, Cancer Letters, vol.360, issue.1, pp.60-67, 2015.

H. S. Phillips, S. Kharbanda, R. Chen, W. F. Forrest, R. H. Soriano et al., Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis, Cancer Cell, vol.9, issue.3, pp.157-173, 2006.

J. Planagumà, L. Minsaas, M. Pons, L. Myhren, G. Garrido et al., Filamin A-Hinge Region 1-EGFP: A Novel Tool for Tracking the Cellular Functions of Filamin A in Real-Time, PLOS ONE, vol.7, issue.8, p.40864, 2012.

M. Pons, I. Izquierdo, M. Andreu-carbó, G. Garrido, J. Planagumà et al., Phosphorylation of filamin A regulates chemokine receptor CCR2 recycling, J Cell Sci, vol.130, issue.2, pp.490-501, 2017.

C. D. Proulx, M. Simaan, E. Escher, S. A. Laporte, G. Guillemette et al., Involvement of a cytoplasmic-tail serine cluster in urotensin II receptor internalization, Biochem J, vol.385, pp.115-123, 2005.

R. Pudas, T. Kiema, P. Butler, M. Stewart, and J. Ylänne, Structural Basis for Vertebrate Filamin Dimerization, Structure, vol.13, issue.1, pp.111-119, 2005.

S. A. Rempel, S. Dudas, S. Ge, and J. A. Gutiérrez, Identification and localization of the cytokine SDF1 and its receptor, CXC chemokine receptor 4, to regions of necrosis and angiogenesis in human glioblastoma, Clin Cancer Res, vol.6, issue.1, pp.102-111, 2000.

S. L. Ritter and R. A. Hall, Fine-tuning of GPCR activity by receptor-interacting proteins, Nat Rev Mol Cell Biol, vol.10, issue.12, pp.819-830, 2009.

M. M. Rosenkilde, L. Gerlach, J. S. Jakobsen, R. T. Skerlj, G. J. Bridger et al., Molecular Mechanism of AMD3100 Antagonism in the CXCR4 Receptor TRANSFER OF BINDING SITE TO THE CXCR3 RECEPTOR, J Biol Chem, vol.279, issue.4, pp.3033-3041, 2004.

A. Sasaki, Y. Masuda, Y. Ohta, K. Ikeda, and K. Watanabe, Filamin Associates with Smads and Regulates Transforming Growth Factor-? Signaling, J Biol Chem, vol.276, issue.21, pp.17871-17877, 2001.

G. Sciumè, A. Soriani, M. Piccoli, L. Frati, A. Santoni et al., CX3CR1/CX3CL1 axis negatively controls glioma cell invasion and is modulated by transforming growth factor-?1, Neuro-oncology, vol.12, issue.7, pp.701-710, 2010.

T. Seck, R. Baron, and W. C. Horne, Binding of Filamin to the C-terminal Tail of the Calcitonin Receptor Controls Recycling, J Biol Chem, vol.278, issue.12, pp.10408-10416, 2003.

J. Segain, M. Rolli-derkinderen, N. Gervois, R. De-la-blétière, D. Loirand et al.,

, Urotensin II is a new chemotactic factor for UT receptor-expressing monocytes, J Immunol, vol.179, issue.2, pp.901-909

I. Segura, C. Lange, E. Knevels, A. Moskalyuk, R. Pulizzi et al., The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A, Cell Reports, vol.14, issue.11, pp.2653-2667, 2016.

M. A. Sells, J. T. Boyd, and J. Chernoff, p21-Activated Kinase 1 (Pak1) Regulates Cell Motility in Mammalian Fibroblasts, J Cell Biol, vol.145, issue.4, pp.837-849, 1999.

D. B. Shieh, J. Godleski, J. E. Herndon, T. Azuma, H. Mercer et al., Cell motility as a prognostic factor in Stage I nonsmall cell lung carcinoma: the role of gelsolin expression, Cancer, vol.85, issue.1, pp.47-57, 1999.

L. M. Traub and J. S. Bonifacino, Cargo recognition in clathrin-mediated endocytosis, Cold Spring Harb Perspect Biol, vol.5, issue.11, p.16790, 2013.

J. Trejo, Internal PDZ ligands: novel endocytic recycling motifs for G protein-coupled receptors, Mol Pharmacol, vol.67, issue.5, pp.1388-1390, 2005.

K. Ueda, Y. Ohta, and H. Hosoya, The carboxy-terminal pleckstrin homology domain of ROCK interacts with filamin-A, Biochemical and Biophysical Research Communications, vol.301, issue.4, pp.886-890, 2003.

H. Uramoto, L. M. Akyürek, and T. Hanagiri, A positive relationship between filamin and VEGF in patients with lung cancer, Anticancer Res, vol.30, issue.10, pp.3939-3944, 2010.

R. K. Vadlamudi, F. Li, L. Adam, D. Nguyen, Y. Ohta et al., Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1, Nature Cell Biology, vol.4, issue.9, pp.681-690, 2002.

A. Velkova, M. A. Carvalho, J. O. Johnson, S. V. Tavtigian, and A. Monteiro, Identification of Filamin A as a BRCA1-interacting protein required for efficient DNA repair, Cell Cycle, vol.9, issue.7, pp.1421-1433, 2010.

G. W. Verhaak-roel, K. A. Hoadley, E. Purdom, V. Wang, Y. Qi et al., Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1, Cancer Cell, vol.17, issue.1, pp.98-110, 2010.

H. Wei, H. Wei, X. Yu, X. Yu, X. Xue et al., Urotensin II receptor as a potential biomarker for the prognosis of hepatocellular carcinoma patients, Oncology Letters, vol.14, issue.3, pp.2749-2756, 2017.

W. Wick and T. Kessler, New glioblastoma heterogeneity atlas -a shared resource, Nat Rev Neurol, vol.14, issue.8, pp.453-454, 2018.

Y. Wu, Z. Song, C. Zhou, S. Xing, P. Zheng et al., Expression of urotensin II and its receptor in human lung adenocarcinoma A549 cells and the effect of urotensin II on lung adenocarcinoma growth in vitro and in vivo, Oncol Rep, vol.24, issue.5, pp.1179-1184, 2010.

V. N. Yadav, D. Zamler, G. J. Baker, P. Kadiyala, A. Erdreich-epstein et al., CXCR4 increases in-vivo glioma perivascular invasion, and reduces radiation induced apoptosis: A genetic knockdown study, Oncotarget, vol.7, issue.50, 2016.

K. Yi, M. Yu, L. Wu, and X. Tan, Effects of urotensin II on functional activity of late endothelial progenitor cells, Peptides, vol.33, issue.1, pp.87-91, 2012.

N. Yoshida, T. Ogata, K. Tanabe, S. Li, M. Nakazato et al., Filamin A-Bound PEBP2?/CBF? Is Retained in the Cytoplasm and Prevented from Functioning as a Partner of the Runx1 Transcription Factor, Molecular and Cellular Biology, vol.25, issue.3, pp.1003-1012, 2005.

X. Yu, P. Wang, Z. Shi, K. Dong, P. Feng et al., Urotensin-II-Mediated Reactive Oxygen Species Generation via NADPH Oxidase Pathway Contributes to Hepatic Oval Cell Proliferation, PLoS ONE, vol.10, issue.12, p.144433, 2015.

D. Zagzag, Y. Lukyanov, L. Lan, M. A. Ali, M. Esencay et al., Hypoxia-inducible factor 1 and VEGF upregulate CXCR4 in glioblastoma: implications for angiogenesis and glioma cell invasion, Lab Invest, vol.86, issue.12, pp.1221-1232, 2006.

K. Zhang, T. Zhu, D. Gao, Y. Zhang, Q. Zhao et al., Filamin A expression correlates with proliferation and invasive properties of human metastatic melanoma tumors: implications for survival in patients, J Cancer Res Clin Oncol, vol.140, issue.11, pp.1913-1926, 2014.

Y. Zhang, J. Zhong, Y. Cui, D. Chen, J. L. Zheng et al., , pp.28-1067, 2019.

, Urotensin II induces endothelial-mesenchymal transition of cardiac microvascular endothelial cells via endoplasmic reticulum stress, J Am Coll Cardiol, vol.70, p.42

Y. Zhang, Z. Kuang, Y. Mao, R. Wei, S. Bao et al., Osteopontin is involved in urotensin II-induced migration of rat aortic adventitial fibroblasts, Peptides, vol.32, issue.12, pp.2452-2458, 2011.

L. Zhao, Y. Wang, Y. Xue, W. Lv, Y. Zhang et al., Critical roles of chemokine receptor CCR5 in regulating glioblastoma proliferation and invasion, Acta Biochimica et Biophysica Sinica, vol.47, issue.11, pp.890-898, 2015.

M. Zheng, Z. Xiaohan, N. Sun, C. Min, Z. Xiaowei et al., RalA employs GRK2 and ?-arrestins for the filamin A-mediated regulation of trafficking and signaling of dopamine D2 and D3 receptor, Biochim Biophys Acta, vol.1863, issue.8, pp.2072-2083, 2016.

X. Zheng, A. Zhou, P. Rouhi, H. Uramoto, J. Borén et al., Hypoxia-induced and calpain-dependent cleavage of filamin A regulates the hypoxic response, PNAS, vol.111, issue.7, pp.2560-2565, 2014.

Z. Zhong, W. Yeow, C. Zou, R. Wassell, C. Wang et al., Cyclin D1/Cyclin-Dependent Kinase 4 Interacts with Filamin A and Affects the Migration and Invasion Potential of Breast Cancer Cells, Cancer Research, vol.70, issue.5, pp.2105-2114, 2010.

A. Zhou, J. H. Hartwig, and L. M. Akyürek, Filamins in cell signaling, transcription and organ development, Trends in Cell Biology, vol.20, issue.2, pp.113-123, 2010.

A. Zhou, A. Toylu, R. K. Nallapalli, G. Nilsson, N. Atabey et al., Filamin A mediates HGF/c-MET signaling in tumor cell migration, International Journal of Cancer, vol.128, issue.4, pp.839-846, 2011.

T. Zhu, H. He, S. Kole, D. Souza, T. Agarwal et al., Filamin Amediated Down-regulation of the Exchange Factor Ras-GRF1 Correlates with Decreased Matrix Metalloproteinase-9 Expression in Human Melanoma Cells, Journal of Biological Chemistry, vol.282, issue.20, pp.14816-14826, 2007.

Y. Zhu, P. Yang, Q. Wang, J. Hu, J. Xue et al., The Effect of CXCR4 Silencing on Epithelial-Mesenchymal Transition Related Genes in Glioma U87 Cells, The Anatomical Record, vol.296, issue.12, pp.1850-1856, 2013.

, Références bib liogra phiques

G. Albertin, D. Guidolin, E. Sorato, R. Spinazzi, A. Mascarin et al., Pro-angiogenic activity of Urotensin-II on different human vascular endothelial cell populations, Regul Pept, vol.157, issue.1-3, pp.64-71, 2009.

R. S. Ames, H. M. Sarau, J. K. Chambers, R. N. Willette, N. V. Aiyar et al., Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14, Nature, vol.401, issue.6750, pp.282-286, 1999.

E. S. Amirian, M. E. Scheurer, R. Zhou, M. R. Wrensch, G. N. Armstrong et al., History of chickenpox in glioma risk: a report from the glioma international case-control study (GICC), Cancer Med, vol.5, issue.6, pp.1352-1358, 2016.

C. Ang and E. C. Nice, Targeted in-gel MRM: a hypothesis driven approach for colorectal cancer biomarker discovery in human feces, J Proteome Res, vol.9, issue.9, pp.4346-4355, 2010.

A. Argentaro, J. Yang, L. Chapman, M. S. Kowalczyk, R. J. Gibbons et al., Structural consequences of disease-causing mutations in the ATRX-DNMT3-DNMT3L (ADD) domain of the chromatin-associated protein ATRX, Proc Natl Acad Sci, vol.104, issue.29, pp.11939-11944, 2007.

H. Awata, C. Huang, M. E. Handlogten, and R. T. Miller, Interaction of the calcium-sensing receptor and filamin, a potential scaffolding protein, J Biol Chem, vol.276, issue.37, pp.34871-34879, 2001.

A. S. Bachmann, J. P. Howard, and C. Vogel, Actin-binding protein filamin A is displayed on the surface of human neuroblastoma cells, Cancer Science, vol.97, issue.12, pp.1359-1365, 2006.

P. Bady, D. Sciuscio, A. Diserens, J. Bloch, M. J. Van-den-bent et al., MGMT methylation analysis of glioblastoma on the Infinium methylation BeadChip identifies two distinct CpG regions associated with gene silencing and outcome, yielding a prediction model for comparisons across datasets, tumor grades, and CIMP-status, Acta Neuropathol, vol.124, issue.4, pp.547-560, 2012.

R. Bai, V. Staedtke, and G. J. Riggins, Molecular targeting of glioblastoma: drug discovery and therapies, Trends Mol Med, vol.17, issue.6, pp.301-312, 2011.

J. Balss, J. Meyer, W. Mueller, A. Korshunov, C. Hartmann et al., Analysis of the IDH1 codon 132 mutation in brain tumors, Acta Neuropathol, vol.116, issue.6, pp.597-602, 2008.

T. T. Batchelor, D. G. Duda, E. Di-tomaso, M. Ancukiewicz, S. R. Plotkin et al., Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma, J Clin Oncol, vol.28, issue.17, pp.2817-2823, 2010.

T. T. Batchelor, E. R. Gerstner, X. Ye, S. Desideri, D. G. Duda et al., Feasibility, phase I, and phase II studies of tandutinib, an oral plateletderived growth factor receptor-? tyrosine kinase inhibitor, in patients with recurrent glioblastoma, Neuro-oncology, vol.19, issue.4, pp.567-575, 2017.

R. Bayat-mokhtari, T. S. Homayouni, N. Baluch, E. Morgatskaya, S. Kumar et al., Combination therapy in combating cancer, Oncotarget, vol.8, issue.23, pp.38022-38043, 2017.

R. G. Bedolla, Y. Wang, A. A. Chamie, K. Siddiqui, S. Mudryj et al., Nuclear versus cytoplasmic localization of Filamin A in Prostate Cancer: immunohistochemical correlation with metastases, Clin Cancer Res, vol.15, issue.3, pp.788-796, 2009.

J. Bellanger, C. Astier, C. Sardet, Y. Ohta, T. P. Stossel et al., Randomized phase II trial of erlotinib versus temozolomide or carmustine in recurrent glioblastoma: EORTC brain tumor group study 26034, van den Bent MJ, vol.2, pp.1268-1274, 2000.

. Bent-mj-van-den, A. F. Carpentier, A. A. Brandes, M. Sanson, M. Taphoorn et al., Adjuvant procarbazine, lomustine, and vincristine improves progression-free survival but not overall survival in newly diagnosed anaplastic oligodendrogliomas and oligoastrocytomas: a randomized European Organisation for Research and Treatment of Cancer phase III trial, J Clin Oncol, vol.24, issue.18, pp.2715-2737, 2006.

T. Beppu, K. Kamada, Y. Yoshida, H. Arai, K. Ogasawara et al., Change of oxygen pressure in glioblastoma tissue under various conditions, J Neurooncol, vol.58, issue.1, pp.47-52, 2002.

G. Bergers, Bone Marrow-Derived Cells in GBM Neovascularization, CNS Cancer: Models, Markers, Prognostic Factors, Targets, and Therapeutic Approaches, pp.749-773, 2009.

M. C. Berndt, C. Gregory, A. Kabral, H. Zola, D. Fournier et al., Purification and preliminary characterization of the glycoprotein Ib complex in the human platelet membrane, European Journal of Biochemistry, vol.151, issue.3, pp.637-649, 1985.

E. Bernhart, S. Damm, A. Wintersperger, C. Nusshold, A. M. Brunner et al., Interference with distinct steps of sphingolipid synthesis and signaling attenuates proliferation of U87MG glioma cells, Biochemical Pharmacology, vol.96, issue.2, pp.119-130, 2015.

F. B. Berry, M. A. O'neill, M. Coca-prados, and M. A. Walter, FOXC1 Transcriptional regulatory activity is impaired by PBX1 in a Filamin A-Mediated manner, Molecular and Cellular Biology, vol.25, issue.4, pp.1415-1424, 2005.

S. Bien-möller, S. Lange, T. Holm, A. Böhm, H. Paland et al., Expression of S1P metabolizing enzymes and receptors correlate with survival time and regulate cell migration in glioblastoma multiforme, Oncotarget, vol.7, issue.11, pp.13031-13046, 2016.

C. Bousquet, J. Guillermet-guibert, N. Saint-laurent, E. Archer-lahlou, F. Lopez et al., Direct binding of p85 to sst2 somatostatin receptor reveals a novel mechanism for inhibiting PI3K pathway, EMBO J, vol.25, issue.17, pp.3943-3954, 2006.

A. Boutet, C. A. De-frutos, P. H. Maxwell, M. J. Mayol, J. Romero et al., Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney, EMBO J, vol.25, issue.23, pp.5603-5613, 2006.

M. Brada, D. Ford, S. Ashley, J. M. Bliss, S. Crowley et al., Risk of second brain tumour after conservative surgery and radiotherapy for pituitary adenoma, BMJ, vol.304, issue.6838, pp.1343-1346, 1992.

D. J. Brat, A. A. Castellano-sanchez, S. B. Hunter, M. Pecot, C. Cohen et al., Pseudopalisades in glioblastoma are hypoxic, express extracellular matrix proteases, and are formed by an actively migrating cell population, Cancer Res, vol.64, issue.3, pp.920-927, 2004.

F. Bröcker, W. Bardenheuer, L. Vieten, K. Jülicher, N. Werner et al., Assignment 1 of human filamin gene FLNB to human chromosome band 3p14.3 and identification of YACs containing the complete FLNB transcribed region, Cytogenet Genome Res, vol.85, issue.3-4, pp.267-268, 1999.

S. M. Bronner, K. A. Merrick, J. Murray, L. Salphati, J. G. Moffat et al., Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma, Bioorg Med Chem Lett, vol.29, issue.16, pp.2294-2301, 2019.

K. A. Browne, R. W. Johnstone, D. A. Jans, and J. A. Trapani, Filamin (280-kDa Actin-binding Protein) is a caspase substrate and is also cleaved directly by the Cytotoxic T Lymphocyte Protease Granzyme B during Apoptosis, J Biol Chem, vol.275, issue.50, pp.39262-39266, 2000.

J. A. Burger and T. J. Kipps, CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment, Blood, vol.107, issue.5, pp.1761-1767, 2006.

J. M. Burns, B. C. Summers, Y. Wang, A. Melikian, R. Berahovich et al., A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development, J Exp Med, vol.203, issue.9, pp.2201-2213, 2006.

K. Burridge and M. Chrzanowska-wodnicka, Focal Adhesions, Contractility, and Signaling, Annual Review of Cell and Developmental Biology, vol.12, issue.1, pp.463-519, 1996.

G. Cairncross, B. Berkey, E. Shaw, R. Jenkins, B. Scheithauer et al., Phase III trial of chemotherapy plus radiotherapy compared with radiotherapy alone for pure and mixed anaplastic oligodendroglioma: Intergroup Radiation Therapy Oncology Group Trial 9402, J Clin Oncol, vol.24, issue.18, pp.2707-2721, 2006.

C. Calabrese, H. Poppleton, M. Kocak, T. L. Hogg, C. Fuller et al., A perivascular niche for brain tumor stem cells, Cancer Cell, vol.11, issue.1, pp.69-82, 2007.

C. Voituriez and R. , Actin flows in cell migration: from locomotion and polarity to trajectories, Current Opinion in Cell Biology, vol.38, pp.12-17, 2016.

P. Carmeliet and R. K. Jain, Angiogenesis in cancer and other diseases, Nature, vol.407, issue.6801, pp.249-257, 2000.

M. S. Carro, W. K. Lim, M. J. Alvarez, R. J. Bollo, X. Zhao et al., The transcriptional network for mesenchymal transformation of brain tumours, Nature, vol.463, issue.7279, pp.318-325, 2010.

E. M. Caspani, P. H. Crossley, C. Redondo-garcia, and S. Martinez, Glioblastoma: a pathogenic crosstalk between tumor cells and pericytes, PLoS ONE, vol.9, issue.7, p.101402, 2014.

M. J. Castañón, G. Walko, L. Winter, and G. Wiche, Plectin-intermediate filament partnership in skin, skeletal muscle, and peripheral nerve, Histochem Cell Biol, vol.140, issue.1, pp.33-53, 2013.

H. Castel, L. Desrues, J. Joubert, M. Tonon, L. Prézeau et al., The G Protein-Coupled Receptor UT of the Neuropeptide Urotensin II displays structural and functional chemokine features, Front Endocrinol, vol.8, 2017.
URL : https://hal.archives-ouvertes.fr/hal-02280590

W. J. Catalona, Management of cancer of the prostate, N Engl J Med, vol.331, issue.15, pp.996-1004, 1994.

R. Chai, K. Zhang, Y. Chang, F. Wu, Y. Liu et al., Systematically characterize the clinical and biological significances of 1p19q genes in 1p/19q non-codeletion glioma, Carcinogenesis, vol.40, issue.10, pp.1229-123, 2019.

C. Chakarova, M. S. Wehnert, K. Uhl, S. Sakthivel, H. Vosberg et al., Genomic structure and fine mapping of the two human filamin gene paralogues FLNB and FLNC and comparative analysis of the filamin gene family, Human Genetics, vol.107, issue.6, pp.597-611, 2000.

A. Chan, Y. Yao, Z. Zhang, N. Chung, J. Liu et al., TERT promoter mutations contribute to subset prognostication of lower-grade gliomas, Modern Pathology, vol.28, issue.2, pp.177-186, 2015.

H. Chao, L. Sung, C. Chen, J. Liu, J. Chen et al., Lycopene inhibits urotensin-II-induced cardiomyocyte hypertrophy in neonatal rat cardiomyocytes, Evid Based Complement Alternat Med, p.724670, 2014.

H. Chen, X. Zhu, P. Cong, M. P. Sheetz, F. Nakamura et al., Differential mechanical stability of Filamin a rod segments, Biophys J, vol.101, issue.5, pp.1231-1237, 2011.

M. Chen and A. Stracher, In situ phosphorylation of platelet actin-binding protein by cAMPdependent protein kinase stabilizes it against proteolysis by calpain, J Biol Chem, vol.264, issue.24, pp.14282-14289, 1989.

P. Cheng, J. Wang, I. Waghmare, S. Sartini, V. Coviello et al., FOXD1-ALDH1A3 signaling Is a determinant for the self-renewal and tumorigenicity of mesenchymal glioma stem cells, Cancer Res, vol.76, issue.24, pp.7219-7230, 2016.

W. Cheng, J. J. Kandel, D. J. Yamashiro, P. Canoll, and D. Anastassiou, A multi-cancer mesenchymal transition gene expression signature is associated with prolonged time to recurrence in glioblastoma, PLoS ONE, vol.7, issue.4, p.34705, 2012.

C. Chetty, S. K. Vanamala, C. S. Gondi, D. H. Dinh, M. Gujrati et al., MMP-9 induces CD44 cleavage and CD44 mediated cell migration in Glioblastoma xenograft cells, Cell Signal, vol.24, issue.2, pp.549-559, 2012.

J. Chiche, K. Ilc, J. Laferrière, E. Trottier, F. Dayan et al., Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH, Cancer Res, vol.69, issue.1, pp.358-368, 2009.
URL : https://hal.archives-ouvertes.fr/hal-00358780

O. L. Chinot, W. Wick, W. Mason, R. Henriksson, F. Saran et al., Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma, N Engl J Med, vol.370, issue.8, pp.709-722, 2014.

D. A. Chistiakov, I. V. Chekhonin, and V. P. Chekhonin, The EGFR variant III mutant as a target for immunotherapy of glioblastoma multiforme, Eur J Pharmacol, vol.810, pp.70-82, 2017.

J. R. Christensen, G. M. Hocky, K. E. Homa, A. N. Morganthaler, S. E. Hitchcock-degregori et al., Competition between Tropomyosin, Fimbrin, and ADF/Cofilin drives their sorting to distinct actin filament networks. eLife 6

K. K. Ciombor and J. Berlin, Aflibercept--a decoy VEGF receptor, Curr Oncol Rep, vol.16, issue.2, p.368, 2014.

P. Cirillo, D. Rosa, S. Pacileo, M. Gargiulo, A. Angri et al., Human urotensin II induces tissue factor and cellular adhesion molecules expression in human coronary endothelial cells: an emerging role for urotensin II in cardiovascular disease, J Thromb Haemost, vol.6, issue.5, pp.726-736, 2008.

A. R. Clark, G. M. Sawyer, S. P. Robertson, and A. J. Sutherland-smith, Skeletal dysplasias due to filamin A mutations result from a gain-of-function mechanism distinct from allelic neurological disorders, Hum Mol Genet, vol.18, issue.24, pp.4791-4800, 2009.

M. H. Cohen, Y. L. Shen, P. Keegan, and R. Pazdur, FDA drug approval summary: bevacizumab (Avastin) as treatment of recurrent glioblastoma multiforme, Oncologist, vol.14, issue.11, pp.1131-1138, 2009.

V. P. Collins, D. Jones, and C. Giannini, Pilocytic astrocytoma: pathology, molecular mechanisms and markers, Acta Neuropathol, vol.129, issue.6, pp.775-788, 2015.

N. Colwell, M. Larion, A. J. Giles, A. N. Seldomridge, S. Sizdahkhani et al., Hypoxia in the glioblastoma microenvironment: shaping the phenotype of cancer stem-like cells, Neuro-Oncology, vol.19, issue.7, pp.887-896, 2017.

J. Condeelis, S. Geosits, and M. Vahey, Isolation of a new actin-binding protein from dictyostelium discoideum, Cell Motility, vol.2, issue.3, pp.273-285, 1982.

J. M. Conlon, H. Tostivint, and H. Vaudry, Somatostatin-and urotensin II-related peptides: molecular diversity and evolutionary perspectives, Regul Pept, vol.69, issue.2, pp.2135-2141, 1997.

L. Cooper, D. A. Gutman, C. Chisolm, C. Appin, J. Kong et al., The tumor microenvironment strongly impacts master transcriptional regulators and gene expression class of glioblastoma, The American Journal of Pathology, vol.180, issue.5, pp.2108-2119, 2012.

J. E. Cortes and R. Pazdur, Docetaxel. JCO, vol.13, issue.10, pp.2643-2655, 1995.

J. Coudeelis, J. Salisbury, and K. Fujiwara, A new protein that gels F actin in the cell cortex of Dictyostelium discoideum, Nature, vol.292, issue.5819, pp.161-162, 1981.

Y. Coulouarn, I. Lihrmann, S. Jegou, Y. Anouar, H. Tostivint et al., Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurons of the spinal cord, Proc Natl Acad Sci, vol.95, issue.26, pp.15803-15808, 1998.

K. L. Covello, J. Kehler, H. Yu, J. D. Gordan, A. M. Arsham et al., HIF-2? regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth, Genes Dev, vol.20, issue.5, pp.557-570, 2006.

D. Cox, J. Condeelis, D. Wessels, D. Soll, H. Kern et al., Targeted disruption of the ABP-120 gene leads to cells with altered motility, J Cell Biol, vol.116, issue.4, pp.943-955, 1992.

D. Cox, D. Wessels, D. R. Soll, J. Hartwig, and J. Condeelis, Re-expression of ABP-120 rescues cytoskeletal, motility, and phagocytosis defects of ABP-120-Dictyostelium mutants, Mol Biol Cell, vol.7, issue.5, pp.803-823, 1996.

V. A. Cuddapah, K. L. Turner, S. Seifert, and H. Sontheimer, Bradykinin-induced chemotaxis of human gliomas requires the activation of KCa3.1 and ClC-3, J Neurosci, vol.33, issue.4, pp.1427-1440, 2013.

I. H. Cukier, Y. Li, and J. M. Lee, Cyclin B1/Cdk1 binds and phosphorylates Filamin A and regulates its ability to cross-link actin, FEBS Letters, vol.581, issue.8, pp.1661-1672, 2007.

P. J. Davies, D. Wallach, M. C. Willingham, I. Pastan, M. Yamaguchi et al., Filamin-actin interaction. Dissociation of binding from gelation by Ca2+-activated proteolysis, J Biol Chem, vol.253, issue.11, pp.4036-4042, 1978.

F. M. Décaillot, M. A. Kazmi, Y. Lin, S. Ray-saha, T. P. Sakmar et al., CXCR7/CXCR4 heterodimer constitutively recruits beta-arrestin to enhance cell migration, J Biol Chem, vol.286, issue.37, pp.32188-32197, 2011.

C. Delbaldo, S. Faivre, C. Dreyer, and E. Raymond, Sunitinib in advanced pancreatic neuroendocrine tumors: latest evidence and clinical potential, Therapeutic Advances in Medical Oncology, vol.4, issue.1, pp.9-18, 2012.

W. Deng, C. Lopez-camacho, J. Tang, D. Mendoza-villanueva, M. -. Mendoza et al., Cytoskeletal protein filamin A is a nucleolar protein that suppresses ribosomal RNA gene transcription, Proceedings of the National Academy of Sciences, vol.109, issue.5, pp.1524-1529, 2012.

D. Renzo, M. F. Poulsom, R. Olivero, M. Comoglio, P. M. Lemoine et al., Expression of the Met/hepatocyte growth factor receptor in human pancreatic cancer, Cancer Res, vol.55, issue.5, pp.1129-1138, 1995.

I. Diebold, A. Petry, M. Burger, J. Hess, and A. Görlach, NOX4 mediates activation of FoxO3a and matrix metalloproteinase-2 expression by urotensin-II, Mol Biol Cell, vol.22, issue.22, pp.4424-4434, 2011.

I. Diebold, A. Petry, K. Sabrane, T. Djordjevic, J. Hess et al., The HIF1 target gene NOX2 promotes angiogenesis through urotensin-II, J Cell Sci, vol.125, pp.956-964, 2012.

T. Djordjevic, R. S. Belaiba, S. Bonello, J. Pfeilschifter, J. Hess et al., Human urotensin II is a novel activator of NADPH oxidase in human pulmonary artery smooth muscle cells, Arterioscler Thromb Vasc Biol, vol.25, issue.3, pp.519-525, 2005.

N. D. Doan, T. Nguyen, M. Létourneau, K. Turcotte, A. Fournier et al., Biochemical and pharmacological characterization of nuclear urotensin-II binding sites in rat heart, British Journal of Pharmacology, vol.166, issue.1, pp.243-257, 2012.
URL : https://hal.archives-ouvertes.fr/pasteur-00818552

S. A. Douglas and E. H. Ohlstein, Human urotensin-II, the most potent mammalian vasoconstrictor identified to date, as a therapeutic target for the management of cardiovascular disease, Trends Cardiovasc Med, vol.10, issue.6, pp.229-237, 2000.

S. A. Douglas, L. Tayara, E. H. Ohlstein, N. Halawa, and A. Giaid, Congestive heart failure and expression of myocardial urotensin II, Lancet, vol.359, issue.9322, pp.1990-1997, 2002.

J. Drappatz, E. Q. Lee, S. Hammond, S. A. Grimm, A. D. Norden et al., Phase I study of panobinostat in combination with bevacizumab for recurrent high-grade glioma, J Neurooncol, vol.107, issue.1, pp.133-138, 2012.

X. Du, X. Li, L. Cai, J. Sun, S. Wang et al., Efficacy and safety of nimotuzumab in addition to radiotherapy and temozolomide for cerebral glioblastoma: a phase II multicenter clinical trial, J Cancer, vol.10, issue.14, pp.3214-3223, 2019.

R. R. Dubreuil, Structure and evolution of the actin crosslinking proteins, BioEssays, vol.13, issue.5, pp.219-226, 1991.

H. F. Dvorak, Tumors: wounds that do not heal-redux, Cancer Immunol Res, vol.3, issue.1, pp.1-11, 2015.

J. E. Eckel-passow, D. H. Lachance, A. M. Molinaro, K. M. Walsh, P. A. Decker et al., Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors, N Engl J Med, vol.372, issue.26, pp.2499-2508, 2015.

A. J. Ehrlicher, F. Nakamura, J. H. Hartwig, D. A. Weitz, and T. P. Stossel, Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A, Nature, vol.478, issue.7368, pp.260-263, 2011.

M. Ehtesham, J. A. Winston, P. Kabos, and R. C. Thompson, CXCR4 expression mediates glioma cell invasiveness, Oncogene, vol.25, pp.2801-2806, 2006.

S. El-hallani, B. Boisselier, F. Peglion, A. Rousseau, C. Colin et al., A new alternative mechanism in glioblastoma vascularization: tubular vasculogenic mimicry, Brain, vol.133, pp.973-982, 2010.

M. C. Elias, K. R. Tozer, J. R. Silber, S. Mikheeva, M. Deng et al., TWIST is expressed in human gliomas and promotes invasion, Neoplasia, vol.7, issue.9, pp.824-837, 2005.

G. D. Englund, R. J. Bodnar, Z. Li, Z. M. Ruggeri, and X. Du, Regulation of von Willebrand factor binding to the platelet glycoprotein Ib-IX by a membrane skeleton-dependent inside-out Signal, J Biol Chem, vol.276, pp.16952-16959, 1920.

R. Enz, R. Enz, and C. Croci, Different binding motifs in metabotropic glutamate receptor type 7b for filamin A, protein phosphatase 1C, protein interacting with protein kinase C (PICK) 1 and syntenin allow the formation of multimeric protein complexes, The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7, vol.514, pp.183-191, 2002.

A. C. Epstein, J. M. Gleadle, L. A. Mcneill, K. S. Hewitson, J. O'rourke et al., C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation, Cell, vol.107, issue.1, pp.507-511, 2001.
URL : https://hal.archives-ouvertes.fr/in2p3-00023372

M. Ereci?ska and I. A. Silver, Tissue oxygen tension and brain sensitivity to hypoxia, Respir Physiol, vol.128, issue.3, pp.263-276, 2001.

M. Esencay, Y. Sarfraz, and D. Zagzag, CXCR7 is induced by hypoxia and mediates glioma cell migration towards SDF-1?, BMC Cancer, vol.13, issue.1, 2013.

G. Esposito, C. Perrino, A. Cannavo, G. G. Schiattarella, F. Borgia et al., EGFR trans-activation by urotensin II receptor is mediated by ?arrestin recruitment and confers cardioprotection in pressure overload-induced cardiac hypertrophy, Basic Res Cardiol, vol.106, issue.4, pp.577-589, 2011.

M. Esteller, J. Garcia-foncillas, E. Andion, S. N. Goodman, O. F. Hidalgo et al., Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents, N Engl J Med, vol.343, pp.1350-1354, 2000.

S. C. Fagerholm, T. J. Hilden, S. M. Nurmi, and C. G. Gahmberg, Specific integrin alpha and beta chain phosphorylations regulate LFA-1 activation through affinity-dependent and -independent mechanisms, J Cell Biol, vol.171, issue.4, pp.705-715, 2005.

S. Farashi and C. L. Harteveld, Molecular basis of ?-thalassemia, Molecules, and Diseases, vol.70, pp.43-53, 2018.

A. Farin, S. O. Suzuki, M. Weiker, J. E. Goldman, J. N. Bruce et al., Transplanted glioma cells migrate and proliferate on host brain vasculature: A dynamic analysis, Glia, vol.53, issue.8, pp.799-808, 2006.

J. T. Finer, R. M. Simmons, and J. A. Spudich, Single myosin molecule mechanics: piconewton forces and nanometre steps, Nature, vol.368, issue.6467, pp.113-119, 1994.

P. R. Fisher, A. A. Noegel, M. Fechheimer, F. Rivero, J. Prassler et al., Photosensory and thermosensory responses in Dictyostelium slugs are specifically impaired by absence of the Factin cross-linking gelation factor (ABP-120), Curr Biol, vol.7, issue.11, pp.379-383, 1997.

T. Flannery, S. Mcquaid, C. Mcgoohan, R. S. Mcconnell, G. Mcgregor et al., Cathepsin S expression: An independent prognostic factor in glioblastoma tumours-a pilot study, International Journal of Cancer, vol.119, issue.4, pp.854-860, 2006.

P. Fucini, C. Renner, C. Herberhold, A. A. Noegel, T. A. Holak et al., Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin ? subunits, Nat Struct Biol, vol.4, issue.3, pp.361-376, 1997.

R. Folberg and A. J. Maniotis, Calcitonin (Thyrocalcitonin), N Engl J Med, vol.112, issue.7-8, pp.349-60, 2004.

J. W. Fox, E. D. Lamperti, Y. Z. Ek?io?lu, S. E. Hong, Y. Feng et al., Mutations in filamin 1 prevent migration of cerebral cortical neurons in human periventricular heterotopia, Neuron, vol.21, issue.6, pp.80651-80651, 1998.

H. S. Friedman, R. E. Mclendon, T. Kerby, M. Dugan, S. H. Bigner et al., DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to Temodal in newly diagnosed malignant glioma, J Clin Oncol, vol.16, issue.12, pp.3851-3857, 1998.

H. S. Friedman, M. D. Prados, P. Y. Wen, T. Mikkelsen, D. Schiff et al., Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma, J Clin Oncol, vol.27, issue.28, pp.4733-4740, 2009.

J. M. Friedman, M. P. Adam, H. H. Ardinger, R. A. Pagon, S. E. Wallace et al., Neurofibromatosis, vol.1, 1993.

K. Furuhashi, M. Inagaki, S. Hatano, K. Fukami, and T. Takenawa, Inositol phospholipid -Induced suppression of F-actin-gelating activity of smooth muscle filamin, Biochemical and Biophysical Research Communications, vol.184, issue.3, pp.1261-1265, 1992.

J. Gagner, Y. Sarfraz, V. Ortenzi, F. M. Alotaibi, L. A. Chiriboga et al., Multifaceted C-X-C chemokine receptor 4 (CXCR4) inhibition interferes with anti-vascular endothelial growth factor therapy-induced glioma dissemination, Am J Pathol, vol.187, issue.9, pp.2080-2094, 2017.

E. Galanis, S. K. Anderson, E. L. Twohy, X. W. Carrero, J. G. Dixon et al., A phase 1 and randomized, placebo-controlled phase 2 trial of bevacizumab plus dasatinib in patients with recurrent glioblastoma, 2019.

, Alliance/North Central Cancer Treatment Group N0872. Cancer, in press

E. Galanis, J. C. Buckner, M. J. Maurer, J. I. Kreisberg, K. Ballman et al., Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: a North Central Cancer Treatment Group Study, J Clin Oncol, vol.23, issue.23, pp.5294-5304, 2005.

E. Galanis, K. A. Jaeckle, M. J. Maurer, J. M. Reid, M. M. Ames et al., Phase II trial of vorinostat in recurrent glioblastoma multiforme: a north central cancer treatment group study, J Clin Oncol, vol.27, issue.12, pp.2052-2058, 2009.

E. García, A. Stracher, and D. Jay, Calcineurin dephosphorylates the C-terminal region of filamin in an important regulatory site: A possible mechanism for filamin mobilization and cell signaling, Archives of Biochemistry and Biophysics, vol.446, issue.2, pp.140-150, 2006.

M. L. Gardel, F. Nakamura, J. H. Hartwig, J. C. Crocker, T. P. Stossel et al., Prestressed F-actin networks cross-linked by hinged filamins replicate mechanical properties of cells, Proc Natl Acad Sci U S A, vol.103, issue.6, pp.1762-1767, 2006.

E. R. Gerstner, K. E. Emblem, A. S. Chi, A. F. Eichler, F. Hochberg et al., Effects of cediranib, a VEGF signaling inhibitor, in combination with chemoradiation on tumor blood flow and survival in newly diagnosed glioblastoma, JCO, vol.30, issue.15_suppl, pp.2009-2009, 2012.

R. J. Gibbons, T. L. Mcdowell, S. Raman, D. M. O'rourke, D. Garrick et al., Mutations in ATRX, encoding a SWI/SNF-like protein, cause diverse changes in the pattern of DNA methylation, Nat Genet, vol.24, issue.4, pp.368-371, 2000.

A. Giese, R. Bjerkvig, M. E. Berens, and M. Westphal, Cost of migration: invasion of malignant gliomas and implications for treatment, J Clin Oncol, vol.21, issue.8, pp.1624-1636, 2003.

A. Giese and M. Westphal, Glioma invasion in the central nervous system, Neurosurgery, vol.39, issue.2, pp.235-250, 1996.

M. Gimona, K. Djinovic-carugo, W. J. Kranewitter, and S. J. Winder, Functional plasticity of CH domains, FEBS Letters, vol.513, issue.1, pp.98-106, 2002.

, Filamin) insert into reconstituted lipid layers. Biochemical and Biophysical Research Communications, vol.259, issue.1, pp.108-112

J. D. Gordan, J. A. Bertout, C. Hu, J. A. Diehl, and M. C. Simon, HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity, Cancer Cell, vol.11, issue.4, pp.335-347, 2007.

R. J. Gorlin and M. M. Cohen, Frontometaphyseal dysplasia. A new syndrome, Am J Dis Child, vol.118, issue.3, pp.487-494, 1969.

J. B. Gorlin, R. Yamin, S. Egan, M. Stewart, T. P. Stossel et al., Human endothelial actin-binding protein (ABP-280, nonmuscle filamin): a molecular leaf spring, J Cell Biol, vol.111, issue.3, pp.1089-105, 1990.

G. L. Gravina, A. Mancini, F. Marampon, A. Colapietro, S. Delle-monache et al., The brain-penetrating CXCR4 antagonist, PRX177561, increases the antitumor effects of bevacizumab and sunitinib in preclinical models of human glioblastoma, J Hematol Oncol, vol.10, issue.1, p.5, 2017.

J. F. De-groot, K. R. Lamborn, S. M. Chang, M. R. Gilbert, T. F. Cloughesy et al., Phase II study of aflibercept in recurrent malignant glioma: a North American Brain Tumor Consortium study, J Clin Oncol, vol.29, pp.2689-2695, 2011.

M. D. Groves, V. K. Puduvalli, K. R. Hess, K. A. Jaeckle, P. Peterson et al., Phase II trial of temozolomide plus the matrix metalloproteinase inhibitor, marimastat, in recurrent and progressive glioblastoma multiforme, JCO, vol.20, issue.5, pp.1383-1388, 2002.

D. Gruson, A. Ginion, N. Decroly, P. Lause, J. L. Vanoverschelde et al.,

, Urotensin II induction of adult cardiomyocytes hypertrophy involves the Akt/GSK-3beta signaling pathway, Peptides, vol.31, issue.7, pp.1326-1333

R. Guerrini, D. Mei, S. Sisodiya, F. Sicca, B. Harding et al., Germline and mosaic mutations of FLN1 in men with periventricular heterotopia, Neurology, vol.63, issue.1, pp.51-56, 2004.

D. Guidolin, G. Albertin, and D. Ribatti, Urotensin-II as an angiogenic factor, Peptides, vol.31, issue.6, pp.1219-1224, 2010.

C. Guo, C. Liang, J. Yang, H. Hu, B. Fan et al., LATS2 inhibits cell proliferation and metastasis through the Hippo signaling pathway in glioma, Oncol Rep, vol.41, issue.5, pp.2753-2761, 2019.

H. Gustavsson, K. Welén, and J. Damber, Transition of an androgen-dependent human prostate cancer cell line into an androgen-independent subline is associated with increased angiogenesis, The Prostate, vol.62, issue.4, pp.364-373, 2005.

A. Hammer, L. Rider, P. Oladimeji, L. Cook, Q. Li et al., Tyrosyl Phosphorylated PAK1 regulates Breast Cancer Cell motility in response to Prolactin through Filamin A, Molecular Endocrinology, vol.27, issue.3, pp.455-465, 2013.

M. E. Hardee and D. Zagzag, Mechanisms of glioma-associated neovascularization, Am J Pathol, vol.181, issue.4, pp.1126-1141, 2012.

K. L. Harms and X. Chen, The functional domains in p53 family proteins exhibit both common and distinct properties, Cell Death & Differentiation, vol.13, issue.6, pp.890-897, 2006.

C. Hartmann, B. Hentschel, M. Tatagiba, J. Schramm, O. Schnell et al., Molecular markers in low-grade gliomas: predictive or prognostic?, Clinical Cancer Research, vol.17, issue.13, pp.4588-4599, 2011.

J. H. Hartwig, Actin-binding protein promotes the bipolar and perpendicular branching of actin filaments, The Journal of Cell Biology, vol.87, issue.3, pp.841-848, 1980.

J. H. Hartwig and T. P. Stossel, Isolation and properties of actin, myosin, and a new actinbinding protein in rabbit alveolar macrophages, J Biol Chem, vol.250, issue.14, pp.5696-5705, 1975.

J. H. Hartwig and T. P. Stossel, Structure of macrophage actin-binding protein molecules in solution and interacting with actin filaments, Journal of Molecular Biology, vol.145, issue.3, pp.563-581, 1981.

K. Hattermann, J. Held-feindt, L. R. Müerköster, S. S. Penfold, M. Schall et al., The chemokine receptor CXCR7 is highly expressed in human glioma cells and mediates antiapoptotic effects, Cancer Res, vol.70, issue.8, pp.3299-3308, 2010.

K. Hayashi and A. Altman, Filamin A is required for T Cell activation mediated by Protein Kinase C-?, The Journal of Immunology, vol.177, issue.3, pp.1721-1728, 2006.

O. K. Heikkinen, S. Ruskamo, P. V. Konarev, D. I. Svergun, T. Iivanainen et al., Atomic structures of two novel immunoglobulin-like domain pairs in the actin cross-linking protein Filamin, J Biol Chem, vol.284, issue.37, pp.25450-25458, 2009.

G. Helmlinger, F. Yuan, M. Dellian, and R. K. Jain, Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation, Nat Med, vol.3, issue.2, pp.177-182, 1997.

M. Himmel, P. Van-der-ven, W. Stöcklein, and D. O. Fürst, The limits of promiscuity: isoform-specific dimerization of filamins, Biochemistry, vol.42, issue.2, pp.430-439, 2003.

E. P. Hoffman, R. H. Brown, and L. M. Kunkel, Dystrophin: The protein product of the duchenne muscular dystrophy locus, Cell, vol.51, issue.6, pp.919-928, 1987.

J. Holash, P. C. Maisonpierre, D. Compton, P. Boland, C. R. Alexander et al., Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF, Science, vol.284, issue.5422, pp.1994-1998, 1999.

X. Hong, F. Jiang, S. N. Kalkanis, Z. G. Zhang, X. Zhang et al., SDF-1 and CXCR4 are up-regulated by VEGF and contribute to glioma cell invasion, Cancer Lett, vol.236, issue.1, pp.39-45, 2006.

P. A. Humphrey, A. J. Wong, B. Vogelstein, M. R. Zalutsky, G. N. Fuller et al., Anti-synthetic peptide antibody reacting at the fusion junction of deletion-mutant epidermal growth factor receptors in human glioblastoma, Proc Natl Acad Sci, vol.87, issue.11, pp.4207-4211, 1990.

R. Hynes, Integrins: A family of cell surface receptors, Cell, vol.48, issue.4, pp.90233-90242, 1987.

R. O. Hynes, Integrins: Versatility, modulation, and signaling in cell adhesion, Cell, vol.69, issue.1, pp.11-25, 1992.

T. Imai, A. Horiuchi, C. Wang, K. Oka, S. Ohira et al., Hypoxia attenuates the expression of E-cadherin via up-regulation of SNAIL in ovarian carcinoma cells, Am J Pathol, vol.163, issue.4, pp.63501-63509, 2003.

R. H. Insall and O. D. Weiner, PIP3, PIP2, and Cell Movement-Similar Messages, Different Meanings? Developmental Cell, vol.1, issue.6, pp.743-747, 2001.

N. Itano, Simple primary structure, complex turnover regulation and multiple roles of hyaluronan, J Biochem, vol.144, issue.2, pp.131-137, 2008.

S. S. Ithychanda, M. Das, Y. Ma, K. Ding, X. Wang et al., 2009-1. Migfilin, a molecular switch in regulation of Integrin activation, J Biol Chem, vol.284, issue.7, pp.4713-4722

S. S. Ithychanda, D. Hsu, H. Li, L. Yan, D. Liu et al., 2009-2. Identification and characterization of multiple similar ligand-binding repeats in Filamin: IMPLICATION ON FILAMIN-MEDIATED RECEPTOR CLUSTERING AND CROSS-TALK, Journal of Biological Chemistry, vol.284, issue.50, pp.35113-35121

S. Ivanov, S. Y. Liao, A. Ivanova, A. Danilkovitch-miagkova, N. Tarasova et al., Expression of hypoxia-inducible cell-surface transmembrane carbonic anhydrases in human cancer, Am J Pathol, vol.158, issue.3, pp.64038-64040, 2001.

J. Ivaska, K. Vuoriluoto, T. Huovinen, I. Izawa, M. Inagaki et al., PKCepsilon-mediated phosphorylation of vimentin controls integrin recycling and motility, EMBO J, vol.24, issue.22, pp.3834-3845, 2005.

Z. Jahed, H. Shams, M. Mehrbod, and M. Mofrad, Mechanotransduction pathways linking the extracellular matrix to the nucleus, International Review of Cell and Molecular Biology, pp.171-220, 2014.

O. Jahn, S. Tenzer, and H. B. Werner, Myelin proteomics: molecular anatomy of an insulating sheath, Mol Neurobiol, vol.40, issue.1, pp.55-72, 2009.

R. K. Jain, Molecular regulation of vessel maturation, Nat Med, vol.9, issue.6, pp.685-693, 2003.

R. K. Jain, Normalizing Tumor Microenvironment to Treat Cancer: Bench to Bedside to Biomarkers, J Clin Oncol, vol.31, issue.17, pp.2205-2218, 2013.

M. Jarry, M. Diallo, C. Lecointre, L. Desrues, T. Tokay et al., The vasoactive peptides urotensin II and urotensin II-related peptide regulate astrocyte activity through common and distinct mechanisms: involvement in cell proliferation, 2010.
URL : https://hal.archives-ouvertes.fr/hal-00479207

, Biochem J, vol.428, issue.1, pp.113-124

D. Jay, E. J. García, L. De-la, and M. Ibarra, In situ determination of a PKA phosphorylation site in the Cterminal region of filamin, Mol Cell Biochem, vol.260, issue.1-2, pp.49-53, 2004.

R. B. Jenkins, H. Blair, K. V. Ballman, C. Giannini, R. M. Arusell et al., A t(1;19)(q10;p10) Mediates the Combined Deletions of 1p and 19q and Predicts a Better Prognosis of Patients with Oligodendroglioma, Cancer Research, vol.66, pp.9852-9861, 1920.

R. L. Jensen, Brain tumor hypoxia: tumorigenesis, angiogenesis, imaging, pseudoprogression, and as a therapeutic target, J Neurooncol, vol.92, issue.3, pp.317-335, 2009.

J. , Y. Ni, J. Xu, S. Yang, C. Duan et al., Silencing Filamin A Inhibits the Invasion and Migration of Breast Cancer Cells by Up-regulating 14-3-3?, Curr Med Sci, vol.38, issue.3, pp.461-466, 2018.

X. Jiang, J. Yue, H. Lu, N. Campbell, Q. Yang et al., Inhibition of Filamin-A reduces cancer metastatic potential, Int J Biol Sci, vol.9, issue.1, pp.67-77, 2012.

Y. Jiao, P. J. Killela, Z. J. Reitman, A. B. Rasheed, C. M. Heaphy et al., Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas, Oncotarget, vol.3, issue.7, pp.709-722, 2012.

S. Jiménez-baranda, C. Gómez-moutón, A. Rojas, L. Martínez-prats, M. E. et al., Filamin-A regulates actin-dependent clustering of HIV receptors, Nature Cell Biology, vol.9, issue.7, pp.838-846, 2007.

A. Joester and A. Faissner, The structure and function of tenascins in the nervous system, Matrix Biology, vol.20, issue.1, pp.13-22, 2001.

J. V. Joseph, S. Conroy, K. Pavlov, P. Sontakke, T. Tomar et al., Hypoxia enhances migration and invasion in glioblastoma by promoting a mesenchymal shift mediated by the HIF1?-ZEB1 axis, Cancer Lett, vol.359, issue.1, pp.107-116, 2015.

H. Karnati, M. Panigrahi, A. Shaik, N. , H. Greig et al., Down regulated expression of Claudin-1 and Claudin-5 and up regulation of, 2014.

R. Kalluri, Basement membranes: structure, assembly and role in tumour angiogenesis, Nature Reviews Cancer, vol.3, issue.6, pp.422-433, 2003.

R. Kalluri and R. A. Weinberg, The basics of epithelial-mesenchymal transition, J Clin Invest, vol.119, issue.6, pp.1420-1428, 2009.

E. Kelly, C. Bailey, and G. Henderson, Agonist-selective mechanisms of GPCR desensitization, Br J Pharmacol, vol.153, issue.1, pp.379-388, 2008.

C. M. Kenific, T. Wittmann, and J. Debnath, Autophagy in adhesion and migration, J Cell Sci, vol.129, issue.20, pp.3685-3693, 2016.

V. G. Keshamouni, G. Michailidis, C. S. Grasso, S. Anthwal, J. R. Strahler et al., Differential protein expression profiling by iTRAQ?2DLC?MS/MS of Lung Cancer Cells undergoing Epithelial-Mesenchymal Transition reveals a Migratory/Invasive Phenotype, J Proteome Res, vol.5, issue.5, pp.1143-1154, 2006.

N. Khaire, R. Müller, R. Blau-wasser, L. Eichinger, M. Schleicher et al., Filamin-regulated F-actin assembly is essential for morphogenesis and controls phototaxis in Dictyostelium, Journal of Biological Chemistry, vol.282, issue.3, pp.1948-1955, 2007.

A. Khattab and D. K. Monga, Turcot Syndrome, StatPearls. Treasure Island (FL): StatPearls Publishing. Available at, 2019.

T. Kiema, Y. Lad, P. Jiang, C. L. Oxley, M. Baldassarre et al., The molecular basis of Filamin binding to Integrins and competition with Talin, Molecular Cell, vol.21, issue.3, pp.337-347, 2006.

E. Kim, J. Park, and S. Um, Filamin A negatively regulates the transcriptional activity of p73? in the cytoplasm, Biochemical and Biophysical Research Communications, vol.362, issue.4, pp.1101-1106, 2007.

E. K. Kim and E. Choi, Pathological roles of MAPK signaling pathways in human diseases, Biochim Biophys Acta, vol.1802, issue.4, pp.396-405, 2010.
URL : https://hal.archives-ouvertes.fr/hal-00566733

H. Kim, F. Nakamura, W. Lee, Y. Shifrin, P. Arora et al., Filamin A is required for vimentinmediated cell adhesion and spreading, American Journal of Physiology-Cell Physiology, vol.298, issue.2, pp.221-236, 2010.

K. Kim, R. R. Gainetdinov, S. A. Laporte, M. G. Caron, and L. S. Barak, G Protein-coupled receptor kinase regulates dopamine D3 Receptor signaling by modulating the stability of a receptor-Filamin-?-Arrestin complex: a case of autoreceptor regulation, J Biol Chem, vol.280, issue.13, pp.12774-12780, 2005.

Y. Konishi, Y. Muragaki, H. Iseki, N. Mitsuhashi, and Y. Okada, Patterns of intracranial Glioblastoma recurrence after aggressive surgical resection and adjuvant management: retrospective analysis of 43 cases, Neurologia medico-chirurgica, vol.52, issue.8, pp.577-586, 2012.

W. H. Koppenol, P. L. Bounds, and C. V. Dang, Otto Warburg's contributions to current concepts of cancer metabolism, Nat Rev Cancer, vol.11, issue.5, pp.325-337, 2011.

C. Koschmann, A. Calinescu, F. J. Nunez, A. Mackay, J. Fazal-salom et al., ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma, Sci Transl Med, vol.8, issue.328, pp.328-356, 2016.

H. A. Krebs, E. Salvin, and J. Wa, The formation of citric and ?-ketoglutaric acids in the mammalian body, Biochem J, vol.32, issue.1, pp.113-117, 1938.

T. N. Kreisl, A. B. Lassman, P. S. Mischel, N. Rosen, H. I. Scher et al., A pilot study of everolimus and gefitinib in the treatment of recurrent glioblastoma (GBM), J Neurooncol, vol.92, issue.1, pp.99-105, 2009.

S. Kumar and V. M. Weaver, Mechanics, malignancy, and metastasis: The force journey of a tumor cell, Cancer and Metastasis Reviews, vol.28, issue.1-2, pp.113-127, 2009.

P. Kunkel, U. Ulbricht, P. Bohlen, M. A. Brockmann, R. Fillbrandt et al., Inhibition of glioma angiogenesis and growth in vivo by systemic treatment with a monoclonal antibody against vascular endothelial growth factor receptor-2, vol.61, pp.6624-6632, 2001.

M. Labussière, D. Stefano, A. L. Gleize, V. Boisselier, B. Giry et al., TERT promoter mutations in gliomas, genetic associations and clinicopathological correlations, Br J Cancer, vol.111, issue.10, pp.2024-2032, 2014.

Y. Lad, P. Jiang, S. Ruskamo, D. S. Harburger, J. Ylänne et al., Structural basis of the Migfilin-Filamin interaction and competition with Integrin ? tails, J Biol Chem, vol.283, issue.50, pp.35154-35163, 2008.

Y. Lad, T. Kiema, P. Jiang, O. T. Pentikäinen, C. H. Coles et al., Structure of three tandem filamin domains reveals auto-inhibition of ligand binding, The EMBO Journal, vol.26, issue.17, pp.3993-4004, 2007.

A. Lai, A. Tran, P. L. Nghiemphu, W. B. Pope, O. E. Solis et al., Phase II study of bevacizumab plus temozolomide during and after radiation therapy for patients with newly diagnosed glioblastoma multiforme, J Clin Oncol, vol.29, issue.2, pp.142-148, 2011.

A. Lal, H. Peters, B. St-croix, Z. A. Haroon, M. W. Dewhirst et al., Transcriptional response to hypoxia in human tumors, J Natl Cancer Inst, vol.93, issue.17, pp.1337-1343, 2001.

R. G. Langham, D. J. Kelly, R. M. Gow, Y. Zhang, J. K. Dowling et al., Increased expression of urotensin II and urotensin II receptor in human diabetic nephropathy, Am J Kidney Dis, vol.44, issue.5, pp.826-831, 2004.

A. B. Lassman, M. R. Rossi, J. J. Raizer, J. R. Razier, L. E. Abrey et al., Molecular study of malignant gliomas treated with epidermal growth factor receptor inhibitors: tissue analysis from North American Brain Tumor Consortium Trials 01-03 and 00-01, Clin Cancer Res, vol.11, issue.21, pp.7841-7850, 2005.

D. A. Lauffenburger and A. F. Horwitz, Cell migration: a physically integrated molecular process, Cell, vol.84, issue.3, pp.359-369, 1996.

C. Lee, Y. Tsai, S. Loh, J. Liu, T. Chen et al., Urotensin II induces interleukin 8 expression in human umbilical vein endothelial cells, PLoS ONE, vol.9, issue.2, p.90278, 2014.

E. Q. Lee, T. J. Kaley, D. G. Duda, D. Schiff, A. B. Lassman et al., A multicenter, phase II, randomized, noncomparative clinical trial of radiation and temozolomide with or without vandetanib in newly diagnosed glioblastoma patients, Clin Cancer Res, vol.21, issue.16, pp.3610-3618, 2015.

E. Q. Lee, D. A. Reardon, D. Schiff, J. Drappatz, A. Muzikansky et al., 2015-1. Phase II study of panobinostat in combination with bevacizumab for recurrent glioblastoma and anaplastic glioma, Neuro-oncology, vol.17, issue.6, pp.862-867
URL : https://hal.archives-ouvertes.fr/hal-01653282

J. M. Lee, S. Dedhar, R. Kalluri, and E. W. Thompson, The epithelial-mesenchymal transition: new insights in signaling, development, and disease, J Cell Biol, vol.172, issue.7, pp.973-981, 2006.

A. D. Leonard, J. P. Thompson, E. L. Hutchinson, S. P. Young, J. Mcdonald et al., Urotensin II receptor expression in human right atrium and aorta: effects of ischaemic heart disease, Br J Anaesth, vol.102, issue.4, pp.477-484, 2009.

J. Leung, G. Ghosal, W. Wang, X. Shen, J. Wang et al., Alpha thalassemia/mental retardation syndrome X-linked gene product ATRX is required for proper replication restart and cellular resistance to replication stress, J Biol Chem, vol.288, issue.9, pp.6342-6350, 2013.

V. A. Levin, S. Phuphanich, A. Yung, W. K. Forsyth, P. A. et al., Randomized, double-blind, placebo-controlled trial of marimastat in glioblastoma multiforme patients following surgery and irradiation, Journal of Neuro-Oncology, vol.78, issue.3, pp.295-302, 2006.

A. J. Levine and A. M. Puzio-kuter, The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes, Science, vol.330, issue.6009, pp.1340-1344, 2010.

C. Li, S. Yu, F. Nakamura, O. T. Pentikäinen, N. Singh et al., Pro-prion binds Filamin A, facilitating its interaction with Integrin ?1, and contributes to Melanomagenesis, J Biol Chem, vol.285, issue.39, pp.30328-30339, 2010.

C. Li, S. Yu, F. Nakamura, S. Yin, J. Xu et al., Binding of pro-prion to filamin A disrupts cytoskeleton and correlates with poor prognosis in pancreatic cancer, J Clin Invest, vol.119, issue.9, pp.2725-2736, 2009.

Y. Li, Z. Shi, X. Yu, P. Feng, and X. Wang, The effects of urotensin II on migration and invasion are mediated by NADPH oxidase-derived reactive oxygen species through the c-Jun N-terminal kinase pathway in human hepatoma cells, Peptides, vol.88, pp.106-114, 2017.

Y. Liang, A. W. Bollen, and N. Gupta, CC chemokine receptor-2A is frequently overexpressed in glioblastoma, J Neurooncol, vol.86, issue.2, pp.153-163, 2008.

R. Lin, V. Canfield, and R. Levenson, Dominant Negative Mutants of Filamin A block cell surface expression of the D2 Dopamine Receptor, PHA, vol.66, issue.4, pp.173-181, 2002.

S. Lindsey and S. A. Langhans, Crosstalk of oncogenic signaling pathways during Epithelial-Mesenchymal Transition, Front Oncol, vol.4, 2014.

M. M. Lino, A. Merlo, and J. Boulay, Notch signaling in glioblastoma: a developmental drug target?, BMC Medicine, vol.8, issue.1, 2010.

B. Liu, J. Cheng, X. Zhang, R. Wang, W. Zhang et al., Global histone modification patterns as prognostic markers to classify glioma patients, Cancer Epidemiol Biomarkers Prev, vol.19, issue.11, pp.2888-2896, 2010.

D. Liu, J. Wang, Z. Zhang, and Y. Wang, The urotension II antagonist SB-710411 arrests fibrosis in CCL4 cirrhotic rats, Mol Med Rep, vol.2, issue.6, pp.953-961, 2009.

Q. Liu, Y. Liu, W. Li, X. Wang, R. Sawaya et al., Genetic, epigenetic, and molecular landscapes of multifocal and multicentric glioblastoma, Acta Neuropathologica, vol.130, issue.4, pp.587-597, 2015.

T. Liu, D. E. Mendes, and C. E. Berkman, Prolonged androgen deprivation leads to overexpression of calpain 2: implications for prostate cancer progression, Int J Oncol, vol.44, issue.2, pp.467-472, 2014.

X. Liu, N. Gerges, A. Korshunov, N. Sabha, D. Khuong-quang et al., Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations, Acta Neuropathol, vol.124, issue.5, pp.615-625, 2012.

Y. Liu, E. Carson-walter, and K. A. Walter, Targeting chemokine receptor CXCR7 inhibits Glioma Cell proliferation and mobility, Anticancer Res, vol.35, issue.1, pp.53-64, 2015.

H. Long, R. Xie, T. Xiang, Z. Zhao, S. Lin et al., Autocrine CCL5 signaling promotes invasion and migration of CD133+ ovarian cancer stem-like cells via NF-?B-mediated MMP-9 upregulation, STEM CELLS, vol.30, issue.10, pp.2309-2319, 2012.

D. T. Loo, S. B. Kanner, and A. Aruffo, Filamin Binds to the Cytoplasmic Domain of the ?1-Integrin IDENTIFICATION OF AMINO ACIDS RESPONSIBLE FOR THIS INTERACTION, J Biol Chem, vol.273, issue.36, pp.23304-23312, 1998.

C. J. Loy, K. S. Sim, and Y. El, Filamin-A fragment localizes to the nucleus to regulate androgen receptor and coactivator functions, Proc Natl Acad Sci U S A, vol.100, issue.8, pp.4562-4567, 2003.

D. Lubanska and L. Porter, Revisiting CDK Inhibitors for Treatment of Glioblastoma Multiforme, Drugs R D, vol.17, issue.2, pp.255-263, 2017.

R. B. Luwor, T. G. Johns, C. Murone, H. Huang, W. K. Cavenee et al., Monoclonal antibody 806 inhibits the growth of tumor xenografts expressing either the de 2-7 or amplified epidermal growth factor receptor (EGFR) but not wild-type EGFR, vol.61, pp.5355-61, 2001.

S. Lv, E. Teugels, J. Sadones, E. Quartier, M. Huylebrouck et al., Correlation between IDH1 gene mutation status and survival of patients treated for recurrent glioma, Anticancer Res, vol.31, issue.12, pp.4457-4463, 2011.

M. Maceyka, S. E. Alvarez, S. Milstien, and S. Spiegel, Filamin A links Sphingosine Kinase 1 and Sphingosine-1-Phosphate receptor 1 at lamellipodia to orchestrate cell migration, Mol Cell Biol, vol.28, issue.18, pp.5687-5697, 2008.

M. L. Macheda, S. Rogers, and J. D. Best, Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer, J Cell Physiol, vol.202, issue.3, pp.654-662, 2005.

J. J. Maguire, R. E. Kuc, M. J. Kleinz, and A. P. Davenport, Immunocytochemical localization of the urotensin-II receptor, UT, to rat and human tissues: relevance to function, Peptides, vol.29, issue.5, pp.735-742, 2008.

R. Mahabir, M. Tanino, A. Elmansuri, L. Wang, T. Kimura et al., Sustained elevation of Snail promotes glial-mesenchymal transition after irradiation in malignant glioma, Neuro-oncology, vol.16, issue.5, pp.671-685, 2014.

M. M. Malagon, M. Molina, M. D. Gahete, M. Duran-prado, A. J. Martinez-fuentes et al., Urotensin II and urotensin II-related peptide activate somatostatin receptor subtypes 2 and 5, Peptides, vol.29, issue.5, pp.711-720, 2008.
URL : https://hal.archives-ouvertes.fr/hal-01973000

A. Mammoto, S. Huang, and D. E. Ingber, Filamin links cell shape and cytoskeletal structure to Rho regulation by controlling accumulation of p190RhoGAP in lipid rafts, Journal of Cell Science, vol.120, issue.3, pp.456-467, 2007.

P. Mao, K. Joshi, J. Li, S. H. Kim, P. Li et al., Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3, Proc Natl Acad Sci U S A, vol.110, issue.21, pp.8644-8653, 2013.

R. J. Marano and N. Ben-jonathan, Minireview: Extrapituitary prolactin: an update on the distribution, regulation, and functions, Mol Endocrinol, vol.28, issue.5, pp.622-633, 2014.

A. Marchese, M. Heiber, T. Nguyen, H. Heng, V. R. Saldivia et al., Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to Interleukin 8, Neuropeptide Y, and Somatostatin Receptors, Genomics, vol.29, issue.2, pp.335-344, 1995.

A. V. Mazin, A. A. Alexeev, and S. C. Kowalczykowski, A Novel Function of Rad54 Protein stabilization on the Rad51 nucleoprotein filament, J Biol Chem, vol.278, issue.16, pp.14029-14036, 2003.

F. Mccormick, K-Ras protein as a drug target, J Mol Med (Berl), vol.94, pp.253-258, 2016.

A. J. Mccoy, P. Fucini, A. A. Noegel, and M. Stewart, Structural basis for dimerization of the Dictyostelium gelation factor (ABP120) rod, nature structural biology, vol.6, issue.9, p.6, 1999.

O. G. Mcdonald, H. Wu, W. Timp, A. Doi, and A. P. Feinberg, Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition, Nature Structural & Molecular Biology, vol.18, issue.8, pp.867-874, 2011.

J. C. Melnick and C. F. Needles, An undiagnosed bone dysplasia. A 2 family study of 4 generations and 3 generations, Am J Roentgenol Radium Ther Nucl Med, vol.97, issue.1, pp.39-48, 1966.

L. Mercurio, A. , M. A. Cecchetti, S. Ricci, A. Bozzuto et al., Targeting CXCR4 by a selective peptide antagonist modulates tumor microenvironment and microglia reactivity in a human glioblastoma model, Journal of Experimental & Clinical Cancer Research, vol.35, issue.1, p.55, 2016.

S. C. Meyer, S. Zuerbig, C. C. Cunningham, J. H. Hartwig, T. Bissell et al., Identification of the region in Actin-binding protein that binds to the cytoplasmic domain of glycoprotein Ib?, J Biol Chem, vol.272, issue.5, pp.2914-2919, 1997.

S. A. Mikheeva, A. M. Mikheev, A. Petit, R. Beyer, R. G. Oxford et al., TWIST1 promotes invasion through mesenchymal change in human glioblastoma, Mol Cancer, vol.9, p.194, 2010.

G. Minniti, D. Traish, S. Ashley, A. Gonsalves, and M. Brada, Risk of second brain tumor after conservative surgery and radiotherapy for pituitary adenoma: update after an additional 10 years, J Clin Endocrinol Metab, vol.90, issue.2, pp.800-804, 2005.

L. Minsaas, J. Planagumà, M. Madziva, B. F. Krakstad, M. Masià-balagué et al., Filamin A binds to CCR2B and regulates its iInternalization, PLOS ONE, vol.5, issue.8, p.12212, 2010.

K. Mishima, T. G. Johns, R. B. Luwor, A. M. Scott, E. Stockert et al., Growth suppression of intracranial xenografted glioblastomas overexpressing mutant epidermal growth factor receptors by systemic administration of monoclonal antibody (mAb) 806, a novel monoclonal antibody directed to the receptor, 2001.

N. Mistry, S. L. Cranmer, Y. Yuan, P. Mangin, S. M. Dopheide et al., Cytoskeletal regulation of the platelet glycoprotein Ib/V/IX-von Willebrand factor interaction, Blood, vol.96, issue.10, pp.3480-3489, 2000.

T. Miyazaki, Y. Uemae, and E. Ishikawa, CXCL12/CXCR4 signaling in glioma stem cells-prospects for therapeutic intervention, Translational Cancer Research, vol.6, issue.2, pp.434-437, 2017.

H. Mohan, M. Krumbholz, R. Sharma, S. Eisele, A. Junker et al., Extracellular matrix in multiple sclerosis lesions: Fibrillar collagens, biglycan and decorin are upregulated and associated with infiltrating immune cells, Brain Pathol, vol.20, issue.5, pp.966-975, 2010.

M. Poeta, V. Massara, M. Capucetti, A. Bonecchi, and R. , Chemokines and chemokine receptors: new targets for cancer immunotherapy, Front Immunol, vol.10, 2019.

B. A. Mooso, R. L. Vinall, C. G. Tepper, R. M. Savoy, J. P. Cheung et al., Enhancing the effectiveness of androgen deprivation in prostate cancer by inducing Filamin A nuclear localization, Endocr Relat Cancer, vol.19, issue.6, 2012.

V. Moreno-manzano, F. J. Rodríguez-jiménez, J. L. Aceña-bonilla, S. Fustero-lardíes, S. Erceg et al., FM19G11, a new hypoxia-inducible factor (HIF) modulator, affects stem cell differentiation status, J Biol Chem, vol.285, issue.2, pp.1333-1342, 2010.

M. Mori, T. Sugo, M. Abe, Y. Shimomura, M. Kurihara et al., Urotensin II is the endogenous ligand of a G-protein-coupled orphan receptor, SENR (GPR14), Biochem Biophys Res Commun, vol.265, issue.1, pp.123-129, 1999.

F. Moro, R. Carrozzo, P. Veggiotti, G. Tortorella, D. Toniolo et al., Familial periventricular heterotopia: missense and distal truncating mutations of the FLN1 gene, Neurology, vol.58, issue.6, pp.916-921, 2002.

R. J. Motzer, B. Escudier, S. Oudard, T. E. Hutson, C. Porta et al., Efficacy of everolimus in advanced renal cell carcinoma: a doubleblind, randomised, placebo-controlled phase III trial, The Lancet, vol.372, issue.9637, pp.61039-61048, 2008.

A. Mughal, L. Zhang, A. Fayzullin, A. Server, Y. Li et al., Patterns of invasive growth in malignant gliomas-the hippocampus emerges as an invasion-spared brain region, Neoplasia, vol.20, issue.7, pp.643-656, 2018.

M. Murakami, Signaling required for blood vessel maintenance: molecular basis and pathological manifestations, Int J Vasc Med, p.293641, 2012.

J. K. Myung, S. A. Choi, S. Kim, K. Wang, and S. Park, Snail plays an oncogenic role in glioblastoma by promoting epithelial mesenchymal transition, Int J Clin Exp Pathol, vol.7, issue.5, pp.1977-1987, 2014.

S. Najib, N. Saint-laurent, J. Estève, S. Schulz, E. Boutet-robinet et al., A switch of G Protein-Coupled receptor binding preference from Phosphoinositide 3-Kinase (PI3K)-p85 to Filamin A negatively controls the PI3K Pathway, Molecular and Cellular Biology, vol.32, issue.5, pp.1004-1016, 2012.

M. Nakada, D. Kita, K. Futami, J. Yamashita, N. Fujimoto et al., Roles of membrane type 1 matrix metalloproteinase and tissue inhibitor of metalloproteinases 2 in invasion and dissemination of human malignant glioma, J Neurosurg, vol.94, issue.3, pp.464-473, 2001.

F. Nakamura, J. H. Hartwig, T. P. Stossel, and P. T. Szymanski, Ca 2+ and Calmodulin regulate the binding of Filamin A to Actin filaments, Journal of Biological Chemistry, vol.280, issue.37, pp.32426-32433, 2005.

F. Nakamura, T. M. Osborn, C. A. Hartemink, J. H. Hartwig, and T. P. Stossel, Structural basis of filamin A functions, J Cell Biol, vol.179, issue.5, pp.1011-1025, 2007.

F. Nakamura, T. P. Stossel, and J. H. Hartwig, The filamins: Organizers of cell structure and function, Cell Adhesion & Migration, vol.5, issue.2, pp.160-169, 2011.

R. K. Nallapalli, M. X. Ibrahim, A. X. Zhou, S. Bandaru, S. N. Sunkara et al., Targeting filamin A reduces K-RAS-induced lung adenocarcinomas and endothelial response to tumor growth in mice, Molecular Cancer, vol.11, issue.1, p.50, 2012.

N. Naslavsky and S. Caplan, The enigmatic endosome -sorting the ins and outs of endocytic trafficking, J Cell Sci, vol.131, issue.13, 2018.

J. P. Neglia, L. L. Robison, M. Stovall, Y. Liu, R. J. Packer et al., New primary neoplasms of the central nervous system in survivors of childhood cancer: a report from the Childhood Cancer Survivor Study, J Natl Cancer Inst, vol.98, issue.21, pp.1528-1537, 2006.

A. Nekrutenko, D. M. Hillis, J. C. Patton, R. D. Bradley, and R. J. Baker, Cytosolic isocitrate dehydrogenase in humans, mice, and voles and phylogenetic analysis of the enzyme family, Molecular Biology and Evolution, vol.15, issue.12, pp.1674-1684, 1998.

B. Neyns, J. Sadones, C. Chaskis, M. Dujardin, H. Everaert et al., Phase II study of sunitinib malate in patients with recurrent high-grade glioma, J Neurooncol, vol.103, issue.3, pp.491-501, 2011.

B. Neyns, J. Sadones, E. Joosens, F. Bouttens, L. Verbeke et al., Stratified phase II trial of cetuximab in patients with recurrent high-grade glioma, Ann Oncol, vol.20, issue.9, pp.1596-1603, 2009.

C. D. Nobes and A. Hall, Rho, rac and cdc42 GTPases: regulators of actin structures, cell adhesion and motility, Biochemical Society Transactions, vol.23, issue.3, pp.456-459, 1995.

M. Noble, C. Pröschel, and M. Mayer-pröschel, Getting a GR(i)P on oligodendrocyte development, Dev Biol, vol.265, issue.1, pp.33-52, 2004.

K. Nordfors, J. Haapasalo, K. Mäkelä, K. J. Granberg, M. Nykter et al., Twist predicts poor outcome of patients with astrocytic glioma, J Clin Pathol, vol.68, issue.11, pp.905-912, 2015.

H. P. Nothacker, Z. Wang, A. M. Mcneill, Y. Saito, S. Merten et al., Identification of the natural ligand of an orphan G-protein-coupled receptor involved in the regulation of vasoconstriction, Nat Cell Biol, vol.1, issue.6, pp.383-385, 1999.

P. E. Oberstein and M. W. Saif, Safety and efficacy of everolimus in adult patients with neuroendocrine tumors, Clin Med Insights Oncol, vol.6, 2012.

M. P. O'connell, J. L. Fiori, K. M. Baugher, F. E. Indig, A. D. French et al., Wnt5A activates the calpain-mediated cleavage of Filamin A, Journal of Investigative Dermatology, vol.129, issue.7, pp.1782-1789, 2009.

V. Odemis, K. Boosmann, A. Heinen, P. Küry, and J. Engele, CXCR7 is an active component of SDF-1 signalling in astrocytes and Schwann cells, J Cell Sci, vol.123, pp.1081-1088, 2010.

S. Oh, E. Ahn, O. Kim, D. Kim, T. Jung et al., The role played by SLUG, an Epithelial-Mesenchymal Transition Factor, in invasion and therapeutic resistance of malignant glioma, Cell Mol Neurobiol, vol.39, issue.6, pp.769-782, 2019.

H. Ohgaki, Y. Kim, and J. P. Steinbach, Nervous system tumors associated with familial tumor syndromes, Curr Opin Neurol, vol.23, issue.6, pp.583-591, 2010.

Y. Ohta and J. H. Hartwig, Actin filament cross-linking by chicken gizzard filamin is regulated by phosphorylation in vitro, Biochemistry, vol.34, issue.20, pp.6745-6754, 1995.

Y. Ohta and J. H. Hartwig, Phosphorylation of actin-binding protein 280 by growth factors is mediated by p90 ribosomal protein S6 kinase, J Biol Chem, vol.271, issue.20, pp.11858-11864, 1996.

Y. Ohta, J. H. Hartwig, and T. P. Stossel, FilGAP, a Rho-and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling, Nature Cell Biology, vol.8, issue.8, pp.803-814, 2006.

Y. Ohta, N. Suzuki, S. Nakamura, J. H. Hartwig, and T. P. Stossel, The small GTPase RalA targets filamin to induce filopodia, Proc Natl Acad Sci U S A, vol.96, issue.5, pp.2122-2128, 1999.

A. Olar and K. D. Aldape, Using the molecular classification of glioblastoma to inform personalized treatment, J Pathol, vol.232, issue.2, pp.165-177, 2014.

D. Onan, R. D. Hannan, and W. G. Thomas, Urotensin II: the old kid in town, Trends Endocrinol Metab, vol.15, issue.4, pp.175-182, 2004.

I. Onoprishvili, S. Ali, M. L. Andria, A. Shpigel, and E. J. Simon, Filamin A mutant lacking actin-binding domain restores ? Opioid Receptor regulation in melanoma cells, Neurochem Res, vol.33, issue.10, pp.2054-2061, 2008.

I. Onoprishvili, M. L. Andria, H. K. Kramer, N. Ancevska-taneva, J. M. Hiller et al., Interaction between the ? Opioid Receptor and Filamin A is Involved in receptor regulation and trafficking, 2003.

, Mol Pharmacol, vol.64, issue.5, pp.1092-1100

B. A. Orr, M. R. Clay, E. M. Pinto, and C. Kesserwan, An update on the central nervous system manifestations of Li-Fraumeni syndrome, Acta Neuropathol, 2019.

Q. T. Ostrom and J. S. Barnholtz-sloan, Current state of our knowledge on brain tumor epidemiology, Curr Neurol Neurosci Rep, vol.11, issue.3, pp.329-335, 2011.

D. M. Ozanne, M. E. Brady, S. Cook, L. Gaughan, D. E. Neal et al., Prostate research group school of surgical and reproductive sciences medical school, vol.14, p.9, 2000.

R. C. Page, J. G. Clark, and S. Misra, Structure of filamin A immunoglobulin-like repeat 10 from Homo sapiens, Acta Cryst F, vol.67, issue.8, pp.871-876, 2011.

X. Pang, Q. Bai, F. Wu, G. Chen, A. Zhang et al., Urotensin II Induces ER Stress and EMT and increase extracellular matrix production in renal tubular epithelial cell in early diabetic mice, KBR, vol.41, issue.4, pp.434-449, 2016.

M. C. Papadopoulos and A. S. Verkman, Aquaporin water channels in the nervous system, Nat Rev Neurosci, vol.14, issue.4, pp.265-277, 2013.

D. M. Park and J. N. Rich, Biology of glioma cancer stem cells, Mol Cells, vol.28, issue.1, pp.7-12, 2009.

E. Parrini, D. Mei, M. Wright, T. Dorn, and R. Guerrini, Mosaic mutations of the FLN1 gene cause a mild phenotype in patients with periventricular heterotopia, Neurogenetics, vol.5, issue.3, pp.191-196, 2004.

E. Parrini, A. Ramazzotti, W. B. Dobyns, D. Mei, F. Moro et al., Periventricular heterotopia: phenotypic heterogeneity and correlation with Filamin A mutations, Brain, vol.129, issue.7, pp.1892-1906, 2006.

D. W. Parsons, S. Jones, X. Zhang, J. C. Lin, R. J. Leary et al., An integrated genomic analysis of human glioblastoma multiforme, Science, vol.321, issue.5897, pp.1807-1819, 2008.

, Patterns of Invasive Growth in Malignant Gliomas-The Hippocampus Emerges as an Invasion-Spared Brain Region | Elsevier Enhanced Reader

A. K. Paulsson, J. A. Holmes, A. M. Peiffer, L. D. Miller, W. Liu et al., Comparison of clinical outcomes and genomic characteristics of single focus and multifocal glioblastoma, J Neurooncol, vol.119, issue.2, pp.429-435, 2014.

W. Paulus, I. Baur, D. Schuppan, and W. Roggendorf, Characterization of integrin receptors in normal and neoplastic human brain, Am J Pathol, vol.143, issue.1, pp.154-163, 1993.

P. Peixoto, A. Etcheverry, M. Aubry, A. Missey, C. Lachat et al., EMT is associated with an epigenetic signature of ECM remodeling genes, Cell Death & Disease, vol.10, issue.3, 2019.
URL : https://hal.archives-ouvertes.fr/hal-02076497

B. J. Perrin and A. Huttenlocher, Calpain. The International Journal of Biochemistry & Cell Biology, vol.34, issue.7, pp.722-725, 2002.

E. Peverelli, E. Giardino, D. Treppiedi, E. Vitali, V. Cambiaghi et al., Filamin A (FLNA) plays an essential role in Somatostatin Receptor 2 (SST2) signaling and stabilization after agonist stimulation in Human and Rat Somatotroph Tumor Cells, Endocrinology, vol.155, issue.8, pp.2932-2941, 2014.

D. J. Picketts, D. R. Higgs, S. Bachoo, D. J. Blake, O. W. Quarrell et al., ATRX encodes a novel member of the SNF2 family of proteins: mutations point to a common mechanism underlying the ATR-X syndrome, Hum Mol Genet, vol.5, issue.12, pp.1899-1907, 1996.

M. Pons, I. Izquierdo, M. Andreu-carbó, G. Garrido, J. Planagumà et al., Phosphorylation of filamin A regulates chemokine receptor CCR2 recycling, J Cell Sci, vol.130, issue.2, pp.490-501, 2017.

G. M. Popowicz, R. Müller, A. A. Noegel, M. Schleicher, R. Huber et al., Molecular structure of the Rod domain of Dictyostelium Filamin, Journal of Molecular Biology, vol.342, issue.5, pp.1637-1646, 2004.

C. Porras-gonzález, J. Ureña, J. J. Egea-guerrero, E. Gordillo-escobar, F. Murillo-cabezas et al., Contractile responses to rat urotensin II in resting and depolarized basilar arteries, J Physiol Biochem, vol.70, issue.1, pp.193-199, 2014.

E. Poteet, G. R. Choudhury, A. Winters, W. Li, M. Ryou et al., Reversing the Warburg effect as a treatment for glioblastoma, J Biol Chem, vol.288, issue.13, pp.9153-9164, 2013.

L. S. Price, J. Leng, M. A. Schwartz, and G. M. Bokoch, Activation of Rac and Cdc42 by Integrins Mediates Cell Spreading, Mol Biol Cell, vol.9, issue.7, pp.1863-1871, 1998.

M. G. Price, D. R. Caprette, and R. H. Gomer, Different temporal patterns of expression result in the same type, amount, and distribution of filamin (ABP) in cardiac and skeletal myofibrils, Cell Motility and the Cytoskeleton, vol.27, issue.3, pp.248-261, 1994.

M. A. Proescholdt, C. Mayer, M. Kubitza, T. Schubert, S. Liao et al., Expression of hypoxia-inducible carbonic anhydrases in brain tumors, Neuro-oncology, vol.7, issue.4, pp.465-475, 2005.

R. Pudas, T. Kiema, P. Butler, M. Stewart, and J. Ylänne, Structural basis for vertebrate Filamin dimerization, Structure, vol.13, issue.1, pp.111-119, 2005.

N. J. Pyne and S. Pyne, Sphingosine 1-phosphate and cancer, Nat Rev Cancer, vol.10, issue.7, pp.489-503, 2010.

S. Rajagopal, J. Kim, S. Ahn, S. Craig, C. M. Lam et al., Beta-arrestin-but not G protein-mediated signaling by the "decoy" receptor CXCR7, Proc Natl Acad Sci, vol.107, issue.2, pp.628-632, 2010.

D. Ravid, D. Chuderland, L. Landsman, Y. Lavie, R. Reich et al., Filamin A is a novel caveolin-1-dependent target in IGF-I-stimulated cancer cell migration, Exp Cell Res, vol.314, issue.15, pp.2762-2773, 2008.

J. E. Rayahin, J. S. Buhrman, Y. Zhang, T. J. Koh, and R. A. Gemeinhart, High and low molecular weight hyaluronic acid differentially influence macrophage activation, ACS Biomater Sci Eng, vol.1, issue.7, pp.481-493, 2015.

Z. Razinia, M. Baldassarre, G. Cantelli, and D. A. Calderwood, ASB2?, an E3 ubiquitin ligase specificity subunit, regulates cell spreading and triggers proteasomal degradation of filamins by targeting the filamin calponin homology 1 domain, J Biol Chem, vol.288, issue.44, pp.32093-32105, 2013.

D. A. Reardon, A. B. Lassman, D. Schiff, S. A. Yunus, E. R. Gerstner et al., Phase 2 and biomarker study of trebananib, an angiopoietin-blocking peptibody, with and without bevacizumab for patients with recurrent glioblastoma, Cancer, vol.124, issue.7, pp.1438-1448, 2018.

G. Reifenberger, H. Wirsching, C. B. Knobbe-thomsen, and M. Weller, Advances in the molecular genetics of gliomas -implications for classification and therapy, Nature Reviews Clinical Oncology, vol.14, issue.7, pp.434-452, 2017.

J. Reifenberger, G. Reifenberger, L. Liu, C. D. James, W. Wechsler et al., Molecular genetic analysis of oligodendroglial tumors shows preferential allelic deletions on 19q and 1p, Am J Pathol, vol.145, issue.5, pp.1175-1190, 1994.

D. E. Reuss, F. Sahm, D. Schrimpf, B. Wiestler, D. Capper et al., ATRX and IDH1-R132H immunohistochemistry with subsequent copy number analysis and IDH sequencing as a basis for an "integrated" diagnostic approach for adult astrocytoma, oligodendroglioma and glioblastoma, Acta Neuropathol, vol.129, issue.1, pp.133-146, 2015.

J. Rhee, N. S. Mahfooz, C. Arregui, J. Lilien, J. Balsamo et al., Activation of the repulsive receptor Roundabout inhibits N-cadherin-mediated cell adhesion, Nat Cell Biol, vol.4, issue.10, pp.798-805, 2002.

L. Ricci-vitiani, R. Pallini, M. Biffoni, M. Todaro, G. Invernici et al., Tumour vascularization via endothelial differentiation of glioblastoma stemlike cells, Nature, vol.468, issue.7325, pp.824-828, 2010.

A. J. Ridley, Cell Migration: integrating signals from front to back, Science, vol.302, issue.5651, pp.1704-1709, 2003.

A. J. Ridley, Rho GTPase signalling in cell migration, Current Opinion in Cell Biology, vol.36, pp.103-112, 2015.

K. Ritchie, C. Seah, J. Moulin, C. Isaac, F. Dick et al., Loss of ATRX leads to chromosome cohesion and congression defects, J Cell Biol, vol.180, issue.2, pp.315-324, 2008.

S. L. Ritter and R. A. Hall, Fine-tuning of GPCR activity by receptor-interacting proteins, Nat Rev Mol Cell Biol, vol.10, issue.12, pp.819-830, 2009.

A. L. Rivera, C. E. Pelloski, M. R. Gilbert, H. Colman, D. Cruz et al., MGMT promoter methylation is predictive of response to radiotherapy and prognostic in the absence of adjuvant alkylating chemotherapy for glioblastoma, Neuro-Oncology, vol.12, issue.2, pp.116-121, 2010.

S. P. Robertson, Filamin A: phenotypic diversity, Current Opinion in Genetics & Development, vol.15, issue.3, pp.301-307, 2005.

S. P. Robertson, S. Twigg, A. J. Sutherland-smith, V. Biancalana, R. J. Gorlin et al., Localized mutations in the gene encoding the cytoskeletal protein filamin A cause diverse malformations in humans, Nat Genet, vol.33, issue.4, pp.487-491, 2003.

D. Rollison, K. J. Helzlsouer, A. J. Alberg, S. Hoffman, J. Hou et al., Serum antibodies to JC virus, BK virus, simian virus 40, and the risk of incident adult astrocytic brain tumors, Cancer Epidemiol Biomarkers Prev, vol.12, issue.5, pp.460-463, 2003.

K. M. Ropponen, M. J. Eskelinen, P. K. Lipponen, E. Alhava, and V. Kosma, Prognostic value of tumourinfiltrating lymphocytes (TILs) in colorectal cancer, The Journal of Pathology, vol.182, issue.3, pp.318-324, 1997.

S. Rosenberg, A. Stracher, and R. C. Lucas, Isolation and characterization of actin and actin-binding protein from human platelets, The Journal of Cell Biology, vol.91, issue.1, pp.201-211, 1981.

S. Ruskamo, R. Gilbert, G. Hofmann, P. Jiang, I. D. Campbell et al., The C-terminal rod 2 fragment of filamin A forms a compact structure that can be extended, Biochemical Journal, vol.446, issue.2, pp.261-269, 2012.

F. D. Russell and P. Molenaar, Investigation of signaling pathways that mediate the inotropic effect of urotensin-II in human heart, Cardiovasc Res, vol.63, issue.4, pp.673-681, 2004.

X. Sainsily, J. Cabana, P. E. Boulais, B. J. Holleran, E. Escher et al., Identification of transmembrane domain 3, 4 & 5 residues that contribute to the formation of the ligandbinding pocket of the urotensin-II receptor, Biochem Pharmacol, vol.86, issue.11, pp.1584-1593, 2013.

N. Salazar, J. C. Carlson, K. Huang, Y. Zheng, C. Oderup et al., A chimeric antibody against ACKR3/CXCR7 in combination with TMZ activates immune responses and extends survival in mouse GBM models, Mol Ther, vol.26, issue.5, pp.1354-1365, 2018.

R. Salimi, S. Bandaru, S. Devarakonda, S. Gökalp, C. Ala et al., Blocking the cleavage of Filamin A by calpain inhibitor decreases tumor cell growth, Anticancer Res, vol.38, issue.4, pp.2079-2085, 2018.

I. Sansal and W. R. Sellers, The biology and clinical relevance of the PTEN tumor suppressor pathway, Journal of Clinical Oncology, vol.22, issue.14, pp.2954-2963, 2004.

M. Sanson, Y. Marie, S. Paris, A. Idbaih, J. Laffaire et al., Isocitrate Dehydrogenase 1 Codon 132 Mutation Is an Important Prognostic Biomarker in Gliomas, Journal of Clinical Oncology, 2009.

M. Santoni, L. Burattini, M. Nabissi, M. B. Morelli, R. Berardi et al., Essential role of Gli proteins in glioblastoma multiforme, Curr Protein Pept Sci, vol.14, issue.2, pp.133-140, 2013.

A. Sasaki, Y. Masuda, Y. Ohta, K. Ikeda, and K. Watanabe, Filamin associates with Smads and regulates Transforming Growth Factor-? signaling, J Biol Chem, vol.276, issue.21, pp.17871-17877, 2001.

T. Savinko, C. Guenther, L. M. Uotila, L. Asens, M. Yao et al., Filamin A is required for optimal T cell Integrin-mediated force transmission, flow adhesion, and T cell trafficking, J Immunol, vol.200, issue.9, pp.3109-3116, 2018.

R. M. Savoy and P. M. Ghosh, The dual role of filamin A in cancer: can't live with (too much of) it, can't live without it, Endocrine Related Cancer, vol.20, issue.6, pp.341-356, 2013.

D. Schiffer, L. Annovazzi, C. Casalone, C. Corona, and M. Mellai, Glioblastoma: microenvironment and niche concept, Cancers (Basel), issue.1, p.11, 2018.

G. Sciumè, A. Santoni, and G. Bernardini, 2010-1. Chemokines and glioma: Invasion and more, Journal of Neuroimmunology, vol.224, issue.1, pp.8-12

A. M. Scott, F. Lee, N. Tebbutt, R. Herbertson, S. S. Gill et al., A phase I clinical trial with monoclonal antibody ch806 targeting transitional state and mutant epidermal growth factor receptors, PNAS, vol.104, issue.10, pp.4071-4076, 2007.

M. Scott, V. Pierotti, H. Storez, E. Lindberg, A. Thuret et al., Cooperative regulation of extracellular signal-regulated kinase activation and cell shape change by Filamin A and ?-Arrestins, Molecular and Cellular Biology, vol.26, issue.9, pp.3432-3445, 2006.
URL : https://hal.archives-ouvertes.fr/inserm-00069767

T. Seck, R. Baron, and W. C. Horne, Binding of Filamin to the C-terminal tail of the Calcitonin Receptor controls recycling, J Biol Chem, vol.278, issue.12, pp.10408-10416, 2003.

R. Seftor, E. A. Seftor, N. Koshikawa, P. S. Meltzer, L. Gardner et al., Cooperative interactions of laminin 5 ?2 chain, matrix metalloproteinase-2, and membrane type-1-matrix/metalloproteinase are required for mimicry of embryonic vasculogenesis by aggressive melanoma, Cancer Res, vol.61, issue.17, pp.6322-6327, 2001.

J. Segain, M. Rolli-derkinderen, N. Gervois, R. De-la-blétière, D. Loirand et al., Urotensin II is a new chemotactic factor for UT receptor-expressing monocytes, J Immunol, vol.179, issue.2, pp.901-909, 2007.

I. Segura, C. Lange, E. Knevels, A. Moskalyuk, R. Pulizzi et al., The oxygen sensor PHD2 controls dendritic spines and synapses via modification of Filamin A, Cell Reports, vol.14, issue.11, pp.2653-2667, 2016.

S. Seidel, B. K. Garvalov, V. Wirta, V. Stechow, L. Schänzer et al., A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2 alpha, Brain, vol.133, pp.983-995, 2010.

M. A. Sells, J. T. Boyd, and J. Chernoff, p21-Activated Kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts, J Cell Biol, vol.145, issue.4, pp.837-849, 1999.

G. L. Semenza, Targeting HIF-1 for cancer therapy, Nat Rev Cancer, vol.3, issue.10, pp.721-732, 2003.

G. L. Semenza, HIF-1: upstream and downstream of cancer metabolism, Curr Opin Genet Dev, vol.20, issue.1, pp.51-56, 2010.

J. M. Sepúlveda-sánchez, M. Á. Vaz, C. Balañá, M. Gil-gil, G. Reynés et al., Phase II trial of dacomitinib, a pan-human EGFR tyrosine kinase inhibitor, in recurrent glioblastoma patients with EGFR amplification, Neuro-oncology, vol.19, issue.11, pp.1522-1531, 2017.

G. Servant, O. D. Weiner, P. Herzmark, T. Balla, J. W. Sedat et al., Polarization of chemoattractant receptor signaling during neutrophil chemotaxis, Science, vol.287, issue.5455, pp.1037-1040, 2000.

K. V. Shah, Polyoma Viruses (JC Virus, BK Virus, and Simian Virus 40) and Human Cancer, pp.461-474, 2000.

C. P. Sharma and W. H. Goldmann, Phosphorylation of actin-binding protein (ABP-280; filamin) by tyrosine kinase p56lck modulates actin filament cross-linking, Cell Biology International, vol.28, issue.12, pp.935-941, 2004.

J. P. Sheehan, M. E. Shaffrey, B. Gupta, J. Larner, J. N. Rich et al., Improving the radiosensitivity of radioresistant and hypoxic glioblastoma, Future Oncol, vol.6, issue.10, pp.1591-1601, 2010.

V. L. Sheen, Filamin A and Filamin B are co-expressed within neurons during periods of neuronal migration and can physically interact, Human Molecular Genetics, vol.11, issue.23, pp.2845-2854, 2002.

V. L. Sheen, P. H. Dixon, J. W. Fox, S. E. Hong, L. Kinton et al., Mutations in the X-linked filamin 1 gene cause periventricular nodular heterotopia in males as well as in females, Hum Mol Genet, vol.10, issue.17, pp.1775-1783, 2001.

A. Shenouda, S. A. Douglas, E. H. Ohlstein, and A. Giaid, Localization of urotensin-II immunoreactivity in normal human kidneys and renal carcinoma, J Histochem Cytochem, vol.50, issue.7, pp.885-889, 2002.

D. B. Shieh, J. Godleski, J. E. Herndon, T. Azuma, H. Mercer et al., Cell motility as a prognostic factor in Stage I nonsmall cell lung carcinoma: the role of gelsolin expression, Survey of Ophthalmology, vol.85, issue.1, pp.1077-1087, 1985.

A. Shukla, G. S. Shukla, and R. C. Srimal, Cadmium-induced alterations in blood-brain barrier permeability and its possible correlation with decreased microvessel antioxidant potential in rat, Hum Exp Toxicol, vol.15, issue.5, pp.400-405, 1996.

F. A. Siebzehnrubl, D. J. Silver, B. Tugertimur, L. P. Deleyrolle, D. Siebzehnrubl et al., The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance, EMBO Mol Med, vol.5, issue.8, pp.1196-1212, 2013.

S. Sigismund, D. Avanzato, and L. Lanzetti, Emerging functions of the EGFR in cancer, Molecular Oncology, vol.12, issue.1, pp.3-20, 2018.

A. Soeda, M. Park, D. Lee, A. Mintz, A. Androutsellis-theotokis et al., Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1alpha, Oncogene, vol.28, issue.45, pp.3949-3959, 2009.

L. A. Sordillo, P. P. Sordillo, and L. Helson, Sphingosine kinase inhibitors as maintenance therapy of glioblastoma after ceramide-induced response, Anticancer Res, vol.36, issue.5, pp.2085-2095, 2016.

A. Sottoriva, I. Spiteri, S. Piccirillo, A. Touloumis, V. P. Collins et al., Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics, Proceedings of the National Academy of Sciences, vol.110, issue.10, pp.4009-4014, 2013.

R. Spinazzi, G. Albertin, B. Nico, D. Guidolin, D. Liddo et al., Urotensin-II and its receptor (UT-R) are expressed in rat brain endothelial cells, and urotensin-II via UT-R stimulates angiogenesis in vivo and in vitro, International Journal of Molecular Medicine, vol.18, issue.6, pp.1107-1112, 2006.

D. F. Stefanik, W. K. Fellows, L. R. Rizkalla, W. M. Rizkalla, P. P. Stefanik et al., Monoclonal antibodies to vascular endothelial growth factor (VEGF) and the VEGF receptor, FLT-1, inhibit the growth of C6 glioma in a mouse xenograft, J Neurooncol, vol.55, issue.2, pp.91-100, 2001.

A. Stirrat, M. Gallagher, S. A. Douglas, E. H. Ohlstein, C. Berry et al., Potent vasodilator responses to human urotensin-II in human pulmonary and abdominal resistance arteries, Am J Physiol Heart Circ Physiol, vol.280, issue.2, pp.925-928, 2001.

R. Stupp, M. E. Hegi, T. Gorlia, S. C. Erridge, J. Perry et al., Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial, Lancet Oncol, vol.15, issue.10, pp.1100-1108, 2014.

R. Stupp, M. E. Hegi, W. P. Mason, M. J. Van-den-bent, M. Taphoorn et al., Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial, Lancet Oncol, vol.10, issue.5, pp.459-466, 2009.

R. Stupp, M. Weller, K. Belanger, U. Bogdahn, S. K. Ludwin et al., Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma, The New England Journal of Medicine, vol.352, issue.10, pp.987-96, 2005.

N. Sugawa, A. J. Ekstrand, C. D. James, and V. P. Collins, Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas, Proc Natl Acad Sci, vol.87, issue.21, pp.8602-8606, 1990.

T. Sugo, Y. Murakami, Y. Shimomura, M. Harada, M. Abe et al., Identification of urotensin II-related peptide as the urotensin II-immunoreactive molecule in the rat brain, Biochem Biophys Res Commun, vol.310, issue.3, pp.860-868, 2003.

G. G. Sun, Y. F. Lu, Y. J. Cheng, W. Hu, G. G. Sun et al., 2014-2. Filamin A regulates MMP-9 expression and suppresses prostate cancer cell migration and invasion, Tumor Biology, vol.35, issue.4, pp.3819-3826

G. G. Sun, S. H. Sheng, S. W. Jing, and W. N. Hu, 2014-3. An antiproliferative gene FLNA regulates migration and invasion of gastric carcinoma cell in vitro and its clinical significance, Tumor Biol, vol.35, issue.3, pp.2641-2648

G. Sun, C. Wei, S. Jing, and W. Hu, Interactions between Filamin A and MMP-9 Regulate Proliferation and Invasion in Renal Cell Carcinoma, Asian Pacific Journal of Cancer Prevention, vol.15, issue.8, pp.3789-3795, 2014.

A. Surcel, E. S. Schiffhauer, D. G. Thomas, Q. Zhu, K. T. Dinapoli et al., Targeting mechanoresponsive proteins in pancreatic cancer: 4-hydroxyacetophenone blocks dissemination and invasion by activating MYH14, Cancer Res: canres.3131, 2018.

P. Swietach, A. Hulikova, V. Rd, and A. L. Harris, New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation, Oncogene, vol.29, issue.50, pp.6509-6521, 2010.

M. Sy, C. Li, Y. S. Xin, and W. , The fatal attraction between pro-prion and filamin A: prion as a marker in human cancers, Biomark Med, vol.4, issue.3, pp.453-464, 2010.

E. Syková and C. Nicholson, Diffusion in brain extracellular space, Physiol Rev, vol.88, issue.4, pp.1277-1340, 2008.

S. Szeto, E. C. Williams, A. D. Rudner, and J. M. Lee, Phosphorylation of filamin A by Cdk1 regulates filamin A localization and daughter cell separation, Experimental Cell Research, vol.330, issue.2, pp.248-266, 2015.

K. Takahashi, K. Totsune, O. Murakami, and S. Shibahara, Expression of urotensin II and urotensin II receptor mRNAs in various human tumor cell lines and secretion of urotensin II-like immunoreactivity by SW-13 adrenocortical carcinoma cells, Peptides, vol.22, issue.7, pp.1175-1179, 2001.

K. Takahashi, K. Totsune, O. Murakami, Z. Arihara, T. Noshiro et al., Expression of urotensin II and its receptor in adrenal tumors and stimulation of proliferation of cultured tumor cells by urotensin II, Peptides, vol.24, issue.2, pp.301-306, 2003.

H. Takala, E. Nurminen, S. M. Nurmi, M. Aatonen, T. Strandin et al., 2008-1. 2 integrin phosphorylation on Thr758 acts as a molecular switch to regulate 14-3-3 and filamin binding, Blood, vol.112, issue.5, pp.1853-1862

T. Heikki, E. Nurminen, S. M. Nurmi, M. Aatonen, T. Strandin et al., 2008-2. ?2 integrin phosphorylation on Thr758 acts as a molecular switch to regulate 14-3-3 and filamin binding, Blood, vol.112, issue.5, pp.1853-1862

M. Tal, D. A. Ammar, M. Karpuj, V. Krizhanovsky, M. Naim et al., A novel putative neuropeptide receptor expressed in neural tissue, including sensory epithelia, Biochemical and Biophysical Research Communications, vol.209, issue.2, pp.752-759, 1995.

K. M. Talasila, G. V. Røsland, H. R. Hagland, E. Eskilsson, I. H. Flønes et al., The angiogenic switch leads to a metabolic shift in human glioblastoma, Neuro Oncol, vol.19, issue.3, pp.383-393, 2017.

J. Tang, S. Wu, H. Liu, R. Stratt, O. G. Barak et al., A novel transcription regulatory complex containing death domain-associated protein and the ATR-X syndrome protein, J Biol Chem, vol.279, pp.20369-20377, 2004.

K. Tano, S. Shiota, J. Collier, R. S. Foote, and S. Mitra, Isolation and structural characterization of a cDNA clone encoding the human DNA repair protein for O6-alkylguanine, Proc Natl Acad Sci, vol.87, issue.2, pp.686-690, 1990.

K. Tasaki, M. Hori, H. Ozaki, H. Karaki, and I. Wakabayashi, Mechanism of human urotensin II-induced contraction in rat aorta, J Pharmacol Sci, vol.94, issue.4, pp.376-383, 2004.

J. W. Taylor, M. Parikh, J. J. Phillips, C. D. James, A. M. Molinaro et al., Phase-2 trial of palbociclib in adult patients with recurrent RB1-positive glioblastoma, J Neurooncol, vol.140, issue.2, pp.477-483, 2018.

D. S. Tews, Adhesive and invasive features in gliomas, Pathology -Research and Practice, vol.196, issue.10, pp.701-711, 2000.

T. A. Thibaudeau and D. M. Smith, A practical review of proteasome pharmacology, Pharmacol Rev, vol.71, issue.2, pp.170-197, 2019.

J. P. Thiery, Epithelial-mesenchymal transitions in tumour progression, Nat Rev Cancer, vol.2, issue.6, pp.442-454, 2002.

R. G. Thorne and C. Nicholson, In vivo diffusion analysis with quantum dots and dextrans predicts the width of brain extracellular space, Proc Natl Acad Sci, vol.103, issue.14, pp.5567-5572, 2006.

H. Tian, X. Liu, W. Han, L. Zhao, B. Yuan et al., Differential expression of filamin A and its clinical significance in breast cancer, Oncol Lett, vol.6, issue.3, pp.681-686, 2013.

Z. Tian, J. Shi, X. Wang, Z. Li, and G. Wang, New cancer suppressor gene for colorectal adenocarcinoma: Filamin A, World J Gastroenterol, vol.21, issue.7, pp.2199-2205, 2015.

U. Tigges, B. Koch, J. Wissing, B. M. Jockusch, and W. H. Ziegler, The F-actin cross-linking and focal adhesion protein filamin A is a ligand and in vivo substrate for protein kinase C alpha, J Biol Chem, vol.278, issue.26, pp.23561-23569, 2003.

H. Tostivint, I. Lihrmann, and H. Vaudry, Urotensin II and somatostatin: two old cousins get together again, Med Sci (Paris), vol.22, issue.5, pp.476-478, 2006.

K. Totsune, K. Takahashi, Z. Arihara, M. Sone, F. Satoh et al., Role of urotensin II in patients on dialysis, Lancet, vol.358, issue.9284, pp.810-811, 2001.

L. M. Traub and J. S. Bonifacino, Cargo recognition in clathrin-mediated endocytosis, Cold Spring Harb Perspect Biol, vol.5, issue.11, p.16790, 2013.

J. Trejo, Internal PDZ ligands: novel endocytic recycling motifs for G protein-coupled receptors, Mol Pharmacol, vol.67, issue.5, pp.1388-1390, 2005.

J. A. Truglia and A. Stracher, Purification and characterization of a calcium dependent sulfhydryl protease from human platelets, Biochemical and Biophysical Research Communications, vol.100, issue.2, pp.814-822, 1981.

T. Tsuji, S. Ibaragi, and G. Hu, Epithelial-Mesenchymal Transition and cell cooperativity in metastasis, Cancer Res, vol.69, issue.18, pp.7135-7139, 2009.

C. Tu and M. You, Obligatory roles of filamin A in E-cadherin-mediated cell-cell adhesion in epidermal keratinocytes, J Dermatol Sci, vol.73, issue.2, pp.142-151, 2014.

A. Tzanidis, R. D. Hannan, W. G. Thomas, D. Onan, D. J. Autelitano et al., Direct actions of urotensin II on the heart: implications for cardiac fibrosis and hypertrophy, Circ Res, vol.93, issue.3, pp.246-253, 2003.

M. S. Ullah, A. J. Davies, and A. P. Halestrap, The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1?-dependent mechanism, J Biol Chem, vol.281, issue.14, pp.9030-9037, 2006.

H. Uramoto, L. M. Akyürek, and T. Hanagiri, A positive relationship between filamin and VEGF in patients with lung cancer, Anticancer Res, vol.30, issue.10, pp.3939-3944, 2010.

A. Vakilian, H. Khorramdelazad, P. Heidari, Z. Sheikh-rezaei, and G. Hassanshahi, CCL2/CCR2 signaling pathway in glioblastoma multiforme, Neurochem Int, vol.103, pp.1-7, 2017.

G. Vázquez-victorio, C. González-espinosa, Z. P. Espinosa-riquer, and M. Macías-silva, Chapter 9 -GPCRs and actin-cytoskeleton dynamics, Cell Biology, pp.165-188, 2016.

K. K. Veeravalli and J. S. Rao, MMP-9 and uPAR regulated glioma cell migration, Cell Adh Migr, vol.6, issue.6, pp.509-512, 2012.

A. Velkova, M. A. Carvalho, J. O. Johnson, S. V. Tavtigian, A. Monteiro et al., Identification of Filamin A as a BRCA1-interacting protein required for efficient DNA repair, J Cell Biol, vol.9, issue.7, pp.235-248, 2000.

R. Vengoji, M. A. Macha, R. K. Nimmakayala, S. Rachagani, J. A. Siddiqui et al., Afatinib and Temozolomide combination inhibits tumorigenesis by targeting EGFRvIII-cMet signaling in glioblastoma cells, J Exp Clin Cancer Res, vol.38, issue.1, p.266, 2019.

R. Verhaak, K. A. Hoadley, E. Purdom, V. Wang, Y. Qi et al., Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1, Cancer Cell, vol.17, issue.1, pp.98-110, 2010.

M. S. Viapiano, S. Hockfield, and R. T. Matthews, BEHAB/brevican requires ADAMTS-mediated proteolytic cleavage to promote glioma invasion, J Neurooncol, vol.88, issue.3, pp.261-272, 2008.

J. Virga, C. D. Szemcsák, J. Reményi-puskár, J. Tóth, T. Hortobágyi et al., Differences in extracellular matrix composition and its role in invasion in primary and secondary intracerebral malignancies, Anticancer Res, vol.37, issue.8, pp.4119-4126, 2017.

E. Vitali, V. Cambiaghi, A. Zerbi, C. Carnaghi, P. Colombo et al., Filamin-A is required to mediate SST2 effects in pancreatic neuroendocrine tumours, Endocrine-Related Cancer, vol.23, issue.3, pp.181-190, 2016.

M. Waisberg, P. Joseph, B. Hale, and D. Beyersmann, Molecular and cellular mechanisms of cadmium carcinogenesis, Toxicology, vol.192, issue.2-3, pp.95-117, 2003.

N. Waldt, A. Seifert, Y. E. Demiray, E. Devroe, B. E. Turk et al., Filamin A phosphorylation at Serine 2152 by the Serine/Threonine Kinase Ndr2 controls TCR-Induced LFA-1 activation in T Cells, Front Immunol, vol.9, 2018.

S. Walenta and W. F. Mueller-klieser, 2004-1. Lactate: mirror and motor of tumor malignancy, Semin Radiat Oncol, vol.14, issue.3, pp.267-274

S. Walenta, T. Schroeder, and W. Mueller-klieser, 2004-2. Lactate in solid malignant tumors: potential basis of a metabolic classification in clinical oncology, Curr Med Chem, vol.11, issue.16, pp.2195-2204

J. Wang, S. Xu, J. Duan, Y. L. Guo, Y. Shi et al., Invasion of white matter tracts by glioma stem cells is regulated by a NOTCH1-SOX2 positive-feedback loop, Nature Neuroscience, vol.22, issue.1, pp.91-105, 2019.

K. Wang, J. F. Ash, and S. J. Singer, Filamin, a new high-molecular-weight protein found in smooth muscle and non-muscle cells, Proc Natl Acad Sci U S A, vol.72, issue.11, pp.4483-4486, 1975.

R. Wang, K. Chadalavada, J. Wilshire, U. Kowalik, K. E. Hovinga et al., Glioblastoma stem-like cells give rise to tumour endothelium, Nature, vol.468, issue.7325, pp.829-833, 2010.

Y. Wang, J. I. Kreisberg, R. G. Bedolla, M. Mikhailova, R. W. Devere-white et al., A 90 kDa fragment of filamin A promotes Casodex-induced growth inhibition in Casodex-resistant androgen receptor positive C4-2 prostate cancer cells, Oncogene, vol.26, issue.41, pp.6061-6070, 2007.

Y. Wang, T. Liu, N. Yang, S. Xu, X. Li et al., Hypoxia and macrophages promote glioblastoma invasion by the CCL4-CCR5 axis, Oncol Rep, vol.36, issue.6, pp.3522-3528, 2016.

Y. Wang, X. Zhao, Z. Shuai, C. Li, Q. Bai et al., Snail promotes epithelialmesenchymal transition and invasiveness in human ovarian cancer cells, Int J Clin Exp Med, vol.8, issue.5, pp.7388-7393, 2015.

K. Wei, C. Huang, P. Chen, L. Feng, T. Wu et al., Evaluation of the prognostic value of CD44 in glioblastoma multiforme, Anticancer Res, vol.30, issue.1, pp.253-259, 2010.

M. Weller, R. Stupp, M. E. Hegi, M. Van-den-bent, J. C. Tonn et al., Personalized care in neuro-oncology coming of age: why we need MGMT and 1p/19q testing for malignant glioma patients in clinical practice, Neuro-Oncology, vol.14, pp.100-108, 2012.

M. Weller, W. Wick, K. Aldape, M. Brada, M. Berger et al., Glioma. Nature Reviews Disease Primers, vol.1, issue.1, 2015.

U. Wellner, J. Schubert, U. C. Burk, O. Schmalhofer, F. Zhu et al., The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs, Nat Cell Biol, vol.11, issue.12, pp.1487-1495, 2009.

J. Welti, S. Loges, S. Dimmeler, and P. Carmeliet, Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancer, J Clin Invest, vol.123, issue.8, pp.3190-3200, 2013.

P. Y. Wen, A. Omuro, M. S. Ahluwalia, H. M. Fathallah-shaykh, N. Mohile et al., Phase I dose-escalation study of the PI3K/mTOR inhibitor voxtalisib (SAR245409, XL765) plus temozolomide with or without radiotherapy in patients with highgrade glioma, Neuro-oncology, vol.17, issue.9, pp.1275-1283, 2015.

P. Y. Wen, M. Touat, B. M. Alexander, I. K. Mellinghoff, S. Ramkissoon et al., Buparlisib in patients with recurrent glioblastoma harboring phosphatidylinositol 3-kinase pathway activation: an open-Label, multicenter, multi-arm, phase II trial, J Clin Oncol, vol.37, issue.9, pp.741-750, 2019.

P. Y. Wen, W. Yung, K. R. Lamborn, P. L. Dahia, Y. Wang et al., Phase I/II study of imatinib mesylate for recurrent malignant gliomas: North American Brain Tumor Consortium Study 99-08, Clin Cancer Res, vol.12, issue.16, pp.4899-4907, 2006.

C. Wesseling, E. Pukkala, K. Neuvonen, T. Kauppinen, P. Boffetta et al., Cancer of the brain and nervous system and occupational exposures in Finnish women, J Occup Environ Med, vol.44, issue.7, pp.663-668, 2002.

P. Wesseling, M. Van-den-bent, and P. A. , Oligodendroglioma: pathology, molecular mechanisms and markers, Acta Neuropathol, vol.129, issue.6, pp.809-827, 2015.

P. Wesseling, D. J. Ruiter, and P. C. Burger, Angiogenesis in brain tumors; pathobiological and clinical aspects, J Neurooncol, vol.32, issue.3, pp.253-265, 1997.

M. Westphal and K. Lamszus, The neurobiology of gliomas: from cell biology to the development of therapeutic approaches, Nat Rev Neurosci, vol.12, issue.9, pp.495-508, 2011.

W. Wick, C. Hartmann, C. Engel, M. Stoffels, J. Felsberg et al., NOA-04 Randomized phase III trial of sequential radiochemotherapy of Anaplastic Glioma with Procarbazine, Lomustine, and Vincristine or Temozolomide, Journal of Clinical Oncology, vol.27, issue.35, pp.5874-5880, 2009.

W. Wick, M. Weller, M. Van-den-bent, M. Sanson, M. Weiler et al., MGMT testing-the challenges for biomarker-based glioma treatment, Nature Reviews Neurology, vol.10, issue.7, pp.372-385, 2014.

C. J. Wickstrand, S. D. Stanley, P. A. Humphrey, C. N. Pegram, G. E. Archer et al., Investigation of a synthetic peptide as immunogen for a variant epidermal growth factor receptor associated with gliomas, J Neuroimmunol, vol.46, issue.1-2, p.90246, 1993.

J. L. Wiemels, J. K. Wiencke, K. T. Kelsey, M. Moghadassi, T. Rice et al., Allergy-Related Polymorphisms Influence Glioma Status and Serum IgE Levels, Cancer Epidemiology Biomarkers & Prevention, vol.16, issue.6, pp.1229-1235, 2007.

T. A. Wilson, M. A. Karajannis, and D. H. Harter, Glioblastoma multiforme: State of the art and future therapeutics, Surg Neurol Int, vol.5, p.64, 2014.

D. Wootten, A. Christopoulos, M. Marti-solano, M. M. Babu, and P. M. Sexton, Mechanisms of signalling and biased agonism in G protein-coupled receptors, Nature Reviews Molecular Cell Biology, vol.19, issue.10, pp.638-653, 2018.

S. Xie, Z. Wang, M. Okano, M. Nogami, Y. Li et al., Cloning, expression and chromosome locations of the human DNMT3 gene family, Gene, vol.236, issue.1, pp.87-95, 1999.

Y. Xie, S. Huo, G. Zhang, F. Zhang, Z. Lian et al., CDA-2 induces cell differentiation through suppressing Twist/SLUG signaling via miR-124 in glioma, J Neurooncol, vol.110, issue.2, pp.179-186, 2012.

Z. Xie, W. Xu, E. W. Davie, and D. W. Chung, Molecular cloning of human ABPL, an actin-binding protein homologue, Biochem Biophys Res Commun, vol.251, issue.3, pp.914-919, 1998.

. Xu-yingjie, T. A. Bismar, J. Su, B. Xu, G. Kristiansen et al., Filamin A regulates focal adhesion disassembly and suppresses breast cancer cell migration and invasion, J Exp Med, vol.207, issue.11, pp.2421-2437, 2010.

. Xu-yin, I. Stamenkovic, and Y. Q. , CD44 attenuates activation of the hippo signaling pathway and is a prime therapeutic target for glioblastoma, Cancer Res, vol.70, issue.6, pp.2455-2464, 2010.

W. Xu, Z. Xie, D. W. Chung, and E. W. Davie, A Novel Human Actin-Binding Protein Homologue That Binds to Platelet Glycoprotein Ib, Blood, vol.92, issue.4, pp.1268-1276, 1998.

Y. Yamaguchi, Lecticans: organizers of the brain extracellular matrix, Cellular and Molecular Life Sciences, vol.57, issue.2, pp.276-289, 2000.

H. Yamazaki, Y. Ohba, N. Tamaoki, and M. Shibuya, A deletion mutation within the ligand binding domain is responsible for activation of epidermal growth factor receptor gene in human brain tumors, Jpn J Cancer Res, vol.81, issue.8, pp.773-779, 1990.

G. Yan, Y. L. Lv, Y. Shi, Y. Shen, L. Yao et al., Endothelial cells promote stem-like phenotype of glioma cells through activating the Hedgehog pathway, J Pathol, vol.234, issue.1, pp.11-22, 2014.

H. Yan, D. W. Parsons, J. G. Mclendon, R. Rasheed, B. A. Yuan et al., IDH1 and IDH2 Mutations in Gliomas, New England Journal of Medicine, vol.360, issue.8, pp.765-773, 2009.

Y. Yan, X. Zuo, and D. Wei, Concise Review: Emerging Role of CD44 in Cancer Stem Cells: a promising biomarker and therapeutic target, STEM CELLS Translational Medicine, vol.4, issue.9, pp.1033-1043, 2015.

L. Yang, J. E. Woerner, B. M. Perry, A. Piwnica-worms, D. Rubin et al., Blocking CXCR4-mediated cyclic AMP suppression inhibits brain tumor growth in vivo, Cancer Res, vol.67, issue.2, pp.651-658, 2007.

L. Yang, C. Lin, L. Wang, H. Guo, and X. Wang, Hypoxia and hypoxia-inducible factors in glioblastoma multiforme progression and therapeutic implications, Exp Cell Res, vol.318, issue.19, pp.2417-2426, 2012.

M. Yang, M. Wu, S. Chiou, P. Chen, C. Liu et al., Direct regulation of TWIST by HIF-1alpha promotes metastasis, Nat Cell Biol, vol.10, issue.3, pp.295-305, 2008.

X. Yao, Y. Ping, J. Chen, C. Xu, D. Chen et al., Glioblastoma stem cells produce vascular endothelial growth factor by activation of a G-protein coupled formylpeptide receptor FPR, J Pathol, vol.215, issue.4, pp.369-376, 2008.

K. Yi, M. Yu, L. Wu, and X. Tan, Effects of urotensin II on functional activity of late endothelial progenitor cells, Peptides, vol.33, issue.1, pp.87-91, 2012.

N. Yoshida, T. Ogata, K. Tanabe, S. Li, M. Nakazato et al.,

A. Filamin and . Pebp2?, CBF? is retained in the cytoplasm and prevented from functioning as a partner of the Runx1 Transcription factor, Mol Cell Biol, vol.25, issue.3, pp.1003-1012

Y. Yoshida, M. Nakada, N. Sugimoto, T. Harada, H. Yasuhiko et al., Sphingosine-1-phosphate receptor type 1 regulates glioma cell proliferation and correlates with patient survival, International Journal of Cancer, vol.126, issue.10, pp.2341-2352, 2010.

N. Young and J. R. Van-brocklyn, Roles of sphingosine-1-phosphate (S1P) receptors in malignant behavior of glioma cells. Differential effects of S1P2 on cell migration and invasiveness, Experimental Cell Research, vol.313, issue.8, pp.1615-1627, 2007.

F. Yu, B. Zhao, N. Panupinthu, J. L. Jewell, I. Lian et al., Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling, Cell, vol.150, issue.4, pp.780-791, 2012.

X. Yu, P. Wang, Z. Shi, K. Dong, P. Feng et al., Urotensin-II-mediated reactive oxygen species generation via NADPH oxidase pathway contributes to hepatic oval cell proliferation, PLoS ONE, vol.10, issue.12, p.144433, 2015.

Y. Yuan and Z. Shen, Interaction with BRCA2 suggests a role for Filamin-1 (hsFLNa) in DNA damage response, J Biol Chem, vol.276, issue.51, pp.48318-48324, 2001.

J. Yue, Q. Wang, H. Lu, M. Brenneman, F. Fan et al., The cytoskeleton protein Filamin-A is required for an efficient recombinational DNA double strand break repair, Cancer Res, vol.69, issue.20, pp.7978-7985, 2009.

D. Zagzag, H. Zhong, J. M. Scalzitti, E. Laughner, J. W. Simons et al., Expression of hypoxiainducible factor 1alpha in brain tumors: association with angiogenesis, invasion, and progression, Cancer, vol.88, issue.11, pp.2606-2618, 2000.

R. Zakaria, I. Lamsoul, S. Uttenweiler-joseph, M. Erard, B. Monsarrat et al., Phosphorylation of serine 323 of ASB2? is pivotal for the targeting of filamin A to degradation, Cellular Signalling, vol.25, issue.12, pp.2823-2830, 2013.
URL : https://hal.archives-ouvertes.fr/hal-02406398

M. Zeisberg and E. G. Neilson, Biomarkers for epithelial-mesenchymal transitions, J Clin Invest, vol.119, issue.6, pp.1429-1437, 2009.

E. T. Zhang, C. B. Inman, and R. O. Weller, Interrelationships of the pia mater and the perivascular (Virchow-Robin) spaces in the human cerebrum, J Anat, vol.170, pp.111-123, 1990.

. Zhang-jin-feng, Y. Chen, X. Qiu, W. Tang, Z. Jian-dong et al., The vascular delta-like ligand-4 (DLL4)-Notch4 signaling correlates with angiogenesis in primary glioblastoma: an immunohistochemical study, Tumor Biol, vol.37, issue.3, pp.3797-3805, 2016.

M. Zhang and G. E. Breitwieser, High affinity interaction with filamin A protects against calcium-sensing receptor degradation, J Biol Chem, vol.280, issue.12, pp.11140-11146, 2005.

Y. Zhang, J. Zhong, Y. Cui, D. Chen, J. L. Zheng et al., GW28-e1067 Urotensin II induces endothelial-mesenchymal transition of cardiac microvascular endothelial cells via endoplasmic reticulum stress, J Am Coll Cardiol, vol.70, p.42, 2016.

Y. Zhang, Z. Kuang, Y. Mao, R. Wei, S. Bao et al., Osteopontin is involved in urotensin II-induced migration of rat aortic adventitial fibroblasts, Peptides, vol.32, issue.12, pp.2452-2458, 2011.

C. Zhao, H. Wang, C. Xiong, and Y. Liu, Hypoxic glioblastoma release exosomal VEGF-A induce the permeability of blood-brain barrier, Biochemical and Biophysical Research Communications, vol.502, issue.3, pp.324-331, 2018.

H. Zhao, G. Chen, and H. Liang, Dual PI3K/mTOR Inhibitor, XL765, suppresses glioblastoma growth by inducing ER stress-dependent apoptosis, Onco Targets Ther, vol.12, pp.5415-5424, 2019.

H. Zhao, J. Feng, K. Seidel, S. Shi, O. Klein et al., Secretion of shh by a neurovascular bundle niche supports mesenchymal stem cell homeostasis in the Adult Mouse Incisor, Cell Stem Cell, vol.14, issue.2, pp.160-173, 2014.

S. Zhao, Y. Lin, W. Xu, W. Jiang, Z. Zha et al., Glioma-Derived Mutations in IDH1 dominantly inhibit IDH1 catalytic activity and Induce HIF-1?, Science, vol.324, issue.5924, pp.261-265, 2009.

M. Zheng, Z. Xiaohan, N. Sun, C. Min, Z. Xiaowei et al., RalA employs GRK2 and ?arrestins for the filamin A-mediated regulation of trafficking and signaling of dopamine D2 and D3 receptor, Biochim Biophys Acta, vol.1863, issue.8, pp.2072-2083, 2016.

X. Zheng, A. Zhou, P. Rouhi, H. Uramoto, J. Borén et al., Hypoxia-induced and calpain-dependent cleavage of filamin A regulates the hypoxic response, PNAS, vol.111, issue.7, pp.2560-2565, 2014.

Z. Zhong, W. Yeow, C. Zou, R. Wassell, C. Wang et al., Cyclin D1/Cyclin-Dependent Kinase 4 interacts with Filamin A and affects the migration and invasion potential of breast cancer cells, Cancer Research, vol.70, issue.5, pp.2105-2114, 2010.

A. Zhou, J. H. Hartwig, and L. M. Akyürek, Filamins in cell signaling, transcription and organ development, Trends in Cell Biology, vol.20, issue.2, pp.113-123, 2010.

A. Zhou, A. Toylu, R. K. Nallapalli, G. Nilsson, N. Atabey et al., Filamin a mediates HGF/c-MET signaling in tumor cell migration, International Journal of Cancer, vol.128, issue.4, pp.839-846, 2011.

T. S. Zhu, M. A. Costello, C. E. Talsma, C. G. Flack, J. G. Crowley et al., Endothelial cells create a stem cell niche in glioblastoma by providing NOTCH ligands that nurture self-renewal of cancer stem-like cells, Cancer Res, vol.71, issue.18, pp.6061-6072, 2011.

D. R. Zimmermann and M. T. Dours-zimmermann, Extracellular matrix of the central nervous system: from neglect to challenge, Histochem Cell Biol, vol.130, issue.4, pp.635-653, 2008.

T. Clavier, A. Mutel, L. Desrues, A. Lefevre-scelles, G. Gastaldi et al., Association between vasoactive peptide urotensin II and cerebral vasospasm after aneurysmal subarachnoid hemorrhage: a potential therapeutic target, J Neurosurg, 2018.
URL : https://hal.archives-ouvertes.fr/hal-02280074

, ABBREVIATIONS ACA = anterior cerebral artery

, AUC = area under the curve

, CSF = cerebrospinal fluid

, DCI = delayed cerebral ischemia

, EVD = external ventricular drainage

, ICU = intensive care unit

. Iqr-=-interquartile-range,

, IRB = institutional review

, MCA = middle cerebral artery; mRS = modified Rankin Scale

, ROC = receiver operating characteristic

. Sah-=-subarachnoid-hemorrhage, SAPS II = Simplified Acute Physiology Score II

;. Se-=-standard-error, . Uii-=-urotensin, and . Ii,

. Ut-=-urotensin,

. Vs-=-vasospasm,

, INCLUDE WHEN CITING Published, 2017.

*. V. and H. , share senior authorship of this work

A. Kindi, H. Hafiane, A. You, Z. Albanese, I. Pilote et al., Circulating levels of the vasoactive peptide urotensin II in patients with acute coronary syndrome and stable coronary artery disease, Peptides, vol.55, pp.151-157, 2014.

T. Al-khindi, R. L. Macdonald, and T. A. Schweizer, Cognitive and functional outcome after aneurysmal subarachnoid hemorrhage, Stroke, vol.41, pp.519-536, 2010.

J. Bellapart, L. Jones, H. Bandeshe, and R. Boots, Plasma endothelin-1 as screening marker for cerebral vasospasm after subarachnoid hemorrhage, Neurocrit Care, vol.20, pp.77-83, 2014.

C. Brulé, N. Perzo, J. E. Joubert, X. Sainsily, R. Leduc et al., Biased signaling regulates the pleiotropic effects of the urotensin II receptor to modulate its cellular behaviors, FASEB J, vol.28, pp.5148-5162, 2014.

H. Castel, M. Diallo, D. Chatenet, J. Leprince, L. Desrues et al., Biochemical and functional characterization of high-affinity urotensin II receptors in rat cortical astrocytes, J Neurochem, vol.99, pp.582-595, 2006.
URL : https://hal.archives-ouvertes.fr/hal-01960748

J. Chuquet, C. Lecrux, D. Chatenet, J. Leprince, L. Chazalviel et al., Effects of urotensin-II on cerebral blood flow and ischemia in anesthetized rats, vol.210, pp.577-584, 2008.
URL : https://hal.archives-ouvertes.fr/hal-01960858

A. V. Ciurea, C. Palade, D. Voinescu, and D. A. Nica, Subarachnoid hemorrhage and cerebral vasospasm-literature review, J Med Life, vol.6, pp.120-125, 2013.

E. S. Connolly, A. A. Rabinstein, J. R. Carhuapoma, C. P. Derdeyn, J. Dion et al., Guidelines for the management of aneurysmal subarachnoid hemorrhage: a guideline for healthcare professionals from the American Heart Association/American Stroke Association, Stroke, vol.43, pp.1711-1737, 2012.

A. R. Dehdashti, B. Mermillod, D. A. Rufenacht, A. Reverdin, and N. De-tribolet, Does treatment modality of intracranial ruptured aneurysms influence the incidence of cerebral vasospasm and clinical outcome?, Cerebrovasc Dis, vol.17, pp.53-60, 2004.

M. El-amki, M. Dubois, A. Lefevre-scelles, N. Magne, M. Roussel et al., Long-lasting cerebral vasospasm, microthrombosis, apoptosis and paravascular alterations associated with neurological deficits in a mouse model of subarachnoid hemorrhage, Mol Neurobiol, vol.55, pp.2763-2779, 2018.
URL : https://hal.archives-ouvertes.fr/hal-02280048

R. M. Elsharkawy, F. Moiety, and H. M. Hegab, Study of urotensin II gene and serum levels in relation to pre-eclampsia

, Clin Exp Obstet Gynecol, vol.41, pp.394-398, 2014.

V. L. Feigin, M. H. Forouzanfar, R. Krishnamurthi, G. A. Mensah, M. Connor et al., Global and regional burden of stroke during 1990-2010: findings from the Global Burden of Disease Study, Lancet, vol.383, pp.245-254, 2010.

C. Fung, D. Marchis, G. M. Katan, M. Seiler, M. Arnold et al., Copeptin as a marker for severity and prognosis of aneurysmal subarachnoid hemorrhage, PLoS One, vol.8, p.53191, 2013.

A. Germanò, M. Caffo, F. F. Angileri, F. Arcadi, J. Newcomb-fernandez et al., NMDA receptor antagonist felbamate reduces behavioral deficits and blood-brain barrier permeability changes after experimental subarachnoid hemorrhage in the rat, J Neurotrauma, vol.24, pp.732-744, 2007.

M. Jarry, M. Diallo, C. Lecointre, L. Desrues, T. Tokay et al., The vasoactive peptides urotensin II and urotensin II-related peptide regulate astrocyte activity through common and distinct mechanisms: involvement in cell proliferation, Biochem J, vol.428, pp.113-124, 2010.
URL : https://hal.archives-ouvertes.fr/hal-00479207

S. C. Johnston, S. Selvin, and D. R. Gress, The burden, trends, and demographics of mortality from subarachnoid hemorrhage, Neurology, vol.50, pp.1413-1418, 1998.

S. G. Keyrouz and M. N. Diringer, Clinical review: prevention and therapy of vasospasm in subarachnoid hemorrhage, Crit Care, vol.11, 2007.

P. Lackner, A. Dietmann, R. Beer, M. Fischer, G. Broessner et al., Cellular microparticles as a marker for cerebral vasospasm in spontaneous subarachnoid hemorrhage, Stroke, vol.41, pp.2353-2357, 2010.

C. Lecointre, L. Desrues, J. E. Joubert, N. Perzo, P. O. Guichet et al., Signaling switch of the urotensin II vasosactive peptide GPCR: prototypic chemotaxic mechanism in glioma, Oncogene, vol.34, pp.5080-5094, 2015.
URL : https://hal.archives-ouvertes.fr/hal-02367872

C. L. Lin, T. Calisaneller, N. Ukita, A. S. Dumont, N. F. Kassell et al., A murine model of subarachnoid hemorrhage-induced cerebral vasospasm, J Neurosci Methods, vol.123, pp.89-97, 2003.

R. L. Macdonald, R. T. Higashida, E. Keller, S. A. Mayer, A. Molyneux et al., Clazosentan, an endothelin receptor antagonist, in patients with aneurysmal subarachnoid haemorrhage undergoing surgical clipping: a randomised, doubleblind, placebo-controlled phase 3 trial (CONSCIOUS-2), Lancet Neurol, vol.10, pp.618-625, 2011.

S. L. Park, B. K. Lee, Y. A. Kim, B. H. Lee, and Y. S. Jung, Inhibitory effect of an urotensin II receptor antagonist on proinflammatory activation induced by urotensin II in human vascular endothelial cells, Biomol Ther (Seoul), vol.21, pp.277-283, 2013.

R. Patacchini, P. Santicioli, S. Giuliani, P. Grieco, E. Novellino et al., Urantide: an ultrapotent urotensin II antagonist peptide in the rat aorta, Br J Pharmacol, vol.140, pp.1155-1158, 2003.

R. M. Pluta, J. Hansen-schwartz, J. Dreier, P. Vajkoczy, R. L. Macdonald et al., Cerebral vasospasm following subarachnoid hemorrhage: time for a new world of thought, vol.31, pp.151-158, 2009.

A. A. Rabinstein, J. A. Friedman, D. A. Nichols, M. A. Pichelmann, R. L. Mcclelland et al., Predictors of outcome after endovascular treatment of cerebral vasospasm, AJNR Am J Neuroradiol, vol.25, pp.1778-1782, 2004.

E. Ronne-engström, P. Enblad, and E. Lundström, Health-related quality of life at median 12 months after aneurysmal subarachnoid hemorrhage, measured with EuroQoL-5D, Acta Neurochir (Wien), vol.155, pp.587-593, 2013.

K. M. Schebesch, A. Brawanski, S. Bele, P. Schödel, A. Herbst et al., Neuropeptide Y-an early biomarker for cerebral vasospasm after aneurysmal subarachnoid hemorrhage, Neurol Res, vol.35, pp.1038-1043, 2013.

K. Takata, H. Sheng, C. O. Borel, D. T. Laskowitz, D. S. Warner et al., Long-term cognitive dysfunction following experimental subarachnoid hemorrhage: new perspectives, Exp Neurol, vol.213, pp.336-344, 2008.

. Clavier,

M. Uyttenboogaart, G. J. Luijckx, P. C. Vroomen, R. E. Stewart, D. Keyser et al., Measuring disability in stroke: relationship between the modified Rankin scale and the Barthel index, J Neurol, vol.254, pp.1113-1117, 2007.

M. Vergouwen, M. Vermeulen, J. Van-gijn, G. Rinkel, E. F. Wijdicks et al., Definition of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage as an outcome event in clinical trials and observational studies: proposal of a multidisciplinary research group, Stroke, vol.41, pp.2391-2395, 2010.

B. Zhao, H. Yang, K. Zheng, Z. Li, Y. Xiong et al., Preoperative and postoperative predictors of long-term outcome after endovascular treatment of poor-grade aneurysmal subarachnoid hemorrhage, J Neurosurg, vol.126, pp.1764-1771, 2017.

, Disclosures This work was supported by the OSEO program

M. Clavier, . Desrues, . Lefevre-scelle, E. Gastaldi, . Amki et al., Critically revising the article: Castel, Clavier, Gérardin, Compère. Reviewed submitted version of manuscript: Castel. Approved the final version of the manuscript on behalf of all authors: Castel. Statistical analysis: Clavier, Dubois, Compère. Administrative/technical/material support: Castel, Desrues. Study supervision: Castel, Proust, Compère, Seinari Normandy maturation program (grant no. HEMORAG-UII/12B01806FM), Fondation pour la recherche sur les AVC (FRM)