J. C. Copin, Y. Gasche, Y. Li, and P. H. Chan, Prolonged hypoxia during cell 620 development protects mature manganese superoxide dismutase-deficient astrocytes 621 from damage by oxidative stress, Faseb J, vol.15, pp.525-534, 2001.

K. L. Wu, C. Hsu, and J. Y. Chan, Impairment of the mitochondrial respiratory enzyme 623 activity triggers sequential activation of apoptosis-inducing factor-dependent and 624 caspase-dependent signaling pathways to induce apoptosis after spinal cord injury

. Neurochem, , vol.101, pp.1552-1566, 2007.

D. Vaudry, T. F. Pamantung, M. Basille, C. Rousselle, A. Fournier et al., , vol.627

J. C. Beauvillain and B. J. Gonzalez, PACAP protects cerebellar granule neurons 628 against oxidative stress-induced apoptosis, Eur. J. Neurosci, vol.15, pp.1451-1460, 2002.

A. A. Juknat, V. Mendez-mdel, A. Quaglino, C. I. Fameli, M. Mena et al.,

L. , Melatonin prevents hydrogen peroxide-induced Bax expression in cultured rat 631 astrocytes, J Pineal Res, vol.38, pp.84-92, 2005.

J. H. Shin, S. W. Kim, C. M. Lim, J. Y. Jeong, C. S. Piao et al., alphaB-633 crystallin suppresses oxidative stress-induced astrocyte apoptosis by inhibiting 634 caspase-3 activation, Neurosci Res, vol.64, pp.355-361, 2009.

M. V. Lopez, M. P. Cuadrado, O. M. Ruiz-poveda, A. M. Del-fresno, and . Accame,

M. E. , Neuroprotective effect of individual ginsenosides on astrocytes primary 637 culture, Biochim. Biophys. Acta, vol.1770, pp.1308-1316, 2007.

T. Sokolova, J. M. Gutterer, J. Hirrlinger, B. Hamprecht, and R. Dringen, Catalase in 639 astroglia-rich primary cultures from rat brain: immunocytochemical localization and 640 33 inactivation during the disposal of hydrogen peroxide, Neurosci. Lett, vol.297, pp.129-132

O. Masmoudi, P. Gandolfo, T. Tokay, J. Leprince, A. Ravni et al., , p.643

M. , Somatostatin down-regulates the expression and release of endozepines from 644 cultured rat astrocytes via distinct receptor subtypes, J. Neurochem, vol.94, pp.561-571

R. Mentlein and P. Dahms, Endopeptidases 24.16 and 24.15 are responsible for the 647 degradation of somatostatin, neurotensin, and other neuropeptides by cultivated rat 648 cortical astrocytes, J. Neurochem, vol.62, pp.27-36, 1994.

R. K. Hopper, S. Carroll, A. M. Aponte, D. T. Johnson, S. French et al., , vol.650

F. A. Witzmann, R. A. Harris, and R. S. Balaban, Mitochondrial matrix 651 phosphoproteome: effect of extra mitochondrial calcium, Biochemistry, vol.45, pp.2524-652, 2006.

S. Kumar, N. Sud, F. V. Fonseca, Y. Hou, and S. M. Black, Shear stress stimulates 654 nitric oxide signaling in pulmonary arterial endothelial cells via a reduction in 655 catalase activity: role of protein kinase C delta, Am. J. Physiol. Lung Cell Mol

. Physiol, , vol.298, pp.105-116, 2010.

C. H. Kim, S. I. Han, S. Y. Lee, H. S. Youk, J. Y. Moon et al.,

J. Joo, Y. M. Park, H. G. Kim, Y. J. Yoo, M. A. Lim et al., Protein 659 kinase C-ERK1/2 signal pathway switches glucose depletion-induced necrosis to 660 apoptosis by regulating superoxide dismutases and suppressing reactive oxygen 661 species production in A549 lung cancer cells, J. Cell Physiol, vol.211, pp.371-385, 2007.

W. C. Huang, P. C. Chen, S. B. Jou, and J. T. Cheng, Protein kinase C and changes in 663 manganese superoxide dismutase gene expression in cultured glial cells, Clin. Exp

, Pharmacol. Physiol, vol.28, pp.822-825, 2001.

M. Dumont, E. Wille, C. Stack, N. Y. Calingasan, M. F. Beal et al.,

, Reduction of oxidative stress, amyloid deposition, and memory deficit by 667 manganese superoxide dismutase overexpression in a transgenic mouse model of 668

, Alzheimer's disease, Faseb J, vol.23, pp.2459-2466, 2009.

K. Schuessel, S. Schafer, T. A. Bayer, C. Czech, L. Pradier et al., , vol.670

W. E. Muller and A. Eckert, Impaired Cu/Zn-SOD activity contributes to increased 671 oxidative damage in APP transgenic mice, Neurobiol. Dis, vol.18, pp.89-99, 2005.

J. Wang, J. H. Ma, and R. G. Giffard, Overexpression of copper/zinc superoxide 673 dismutase decreases ischemia-like astrocyte injury. Free Radic, Biol. Med, vol.38, pp.1112-674, 2005.

S. Peuchen, J. P. Bolanos, S. J. Heales, A. Almeida, M. R. Duchen et al., 676 Interrelationships between astrocyte function, oxidative stress and antioxidant status 677 within the central nervous system, Prog. Neurobiol, vol.52, pp.261-281

N. J. Abbott, Astrocyte-endothelial interactions and blood-brain barrier permeability, J Anat, pp.629-638, 0200.

A. Y. Abramov, L. Canevari, and M. R. Duchen, Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase, J Neurosci, vol.24, pp.565-575, 2004.

A. Y. Abramov and M. R. Duchen, The role of an astrocytic NADPH oxidase in the neurotoxicity of amyloid beta peptides, Philos Trans R Soc Lond B Biol Sci, vol.360, pp.2309-2314, 2005.

B. Agerberth, A. Boman, M. Andersson, H. Jornvall, V. Mutt et al., Isolation of three antibacterial peptides from pig intestine: gastric inhibitory polypeptide (7-42), diazepambinding inhibitor (32-86) and a novel factor, peptide 3910, Eur J Biochem, vol.216, pp.623-629, 1993.

K. T. Akama and L. J. Van-eldik, Beta-amyloid stimulation of inducible nitric-oxide synthase in astrocytes is interleukin-1beta-and tumor necrosis factor-alpha (TNFalpha)-dependent, and involves a TNFalpha receptor-associated factor-and NFkappaB-inducing kinase-dependent signaling mechanism, J Biol Chem, vol.275, pp.7918-7924, 2000.

M. K. Akinci and P. R. Schofield, Widespread expression of GABA(A) receptor subunits in peripheral tissues, Neurosci Res, vol.35, pp.145-153, 1999.

R. Alarcon, C. Fuenzalida, M. Santibanez, and R. Von-bernhardi, Expression of scavenger receptors in glial cells. Comparing the adhesion of astrocytes and microglia from neonatal rats to surface-bound beta-amyloid, J Biol Chem, vol.280, pp.30406-30415, 2005.

H. Alho, E. Costa, P. Ferrero, M. Fujimoto, D. Cosenza-murphy et al., , 1985.

, Diazepam-binding inhibitor: a neuropeptide located in selected neuronal populations of rat brain, Science, vol.229, pp.179-182

H. Alho, T. Harjuntausta, R. Schultz, M. Pelto-huikko, and P. Bovolin, Immunohistochemistry of diazepam binding inhibitor (DBI) in the central nervous system and peripheral organs: its possible role as an endogenous regulator of different types of benzodiazepine receptors, Neuropharmacology, vol.30, pp.1381-1386, 1991.

H. Alho, M. Kolmer, T. Harjuntausta, and P. Helen, Increased expression of diazepam binding inhibitor in human brain tumors, Cell Growth Differ, vol.6, pp.309-314, 1995.

H. Alho, V. Varga, and K. E. Krueger, Expression of mitochondrial benzodiazepine receptor and its putative endogenous ligand diazepam binding inhibitor in cultured primary astrocytes and C-6 cells: relation to cell growth, Cell Growth Differ, vol.5, pp.1005-1014, 1994.

H. Ali, S. Sozzani, I. Fisher, A. J. Barr, R. M. Richardson et al., Differential regulation of formyl peptide and platelet-activating factor receptors. Role of phospholipase Cbeta3 phosphorylation by protein kinase A, J Biol Chem, vol.273, pp.11012-11016, 1998.

I. Allaman, M. Gavillet, M. Belanger, T. Laroche, D. Viertl et al., Amyloid-beta aggregates cause alterations of astrocytic metabolic phenotype: impact on neuronal viability, J Neurosci, vol.30, pp.3326-3338, 2010.

J. W. Allen, B. A. Eldadah, X. Huang, S. M. Knoblach, and A. I. Faden, Multiple caspases are involved in beta-amyloid-induced neuronal apoptosis, J Neurosci Res, vol.65, pp.45-53, 2001.

S. J. Allen, S. H. Macgowan, S. Tyler, G. K. Wilcock, A. G. Robertson et al.,

K. Dawbarn and D. , Reduced cholinergic function in normal and Alzheimer's disease brain is associated with apolipoprotein E4 genotype, Neurosci Lett, vol.239, pp.33-36, 1997.

J. Amin, A. Brooks-kayal, and D. S. Weiss, Two tyrosine residues on the alpha subunit are crucial for benzodiazepine binding and allosteric modulation of gamma-aminobutyric acidA receptors, Mol Pharmacol, vol.51, pp.833-841, 1997.

K. V. Andersen and F. M. Poulsen, The three-dimensional structure of acyl-coenzyme A binding protein from bovine liver: structural refinement using heteronuclear multidimensional NMR spectroscopy, J Biomol NMR, vol.3, pp.271-284, 1993.

N. Andreasen, J. Gottfries, E. Vanmechelen, H. Vanderstichele, P. Davidson et al., Evaluation of CSF biomarkers for axonal and neuronal degeneration, gliosis, and beta-amyloid metabolism in Alzheimer's disease, J Neurol Neurosurg Psychiatry, vol.71, pp.557-558, 2001.

C. Andrei, C. Dazzi, L. Lotti, M. R. Torrisi, G. Chimini et al., The secretory route of the leaderless protein interleukin 1beta involves exocytosis of endolysosome-related vesicles, Mol Biol Cell, vol.10, pp.1463-1475, 1999.

R. R. Anholt, E. B. De-souza, M. L. Oster-granite, and S. H. Snyder, Peripheral-type benzodiazepine receptors: autoradiographic localization in whole-body sections of neonatal rats, J Pharmacol Exp Ther, vol.233, pp.517-526, 1985.

R. R. Anholt, K. M. Murphy, G. E. Mack, and S. H. Snyder, Peripheral-type benzodiazepine receptors in the central nervous system: localization to olfactory nerves, J Neurosci, vol.4, pp.593-603, 1984.

M. Anzini, A. Cappelli, S. Vomero, G. Giorgi, T. Langer et al., Molecular basis of peripheral vs central benzodiazepine receptor selectivity in a new class of peripheral benzodiazepine receptor ligands related to alpidem, J Med Chem, vol.39, pp.4275-4284, 1996.

J. Apelt and R. Schliebs, Beta-amyloid-induced glial expression of both pro-and antiinflammatory cytokines in cerebral cortex of aged transgenic Tg2576 mice with Alzheimer plaque pathology, Brain Res, vol.894, pp.21-30, 2001.

A. Araque, R. P. Sanzgiri, V. Parpura, and P. G. Haydon, Astrocyte-induced modulation of synaptic transmission, Can J Physiol Pharmacol, vol.77, pp.699-706, 1999.

D. M. Araujo and C. W. Cotman, Beta-amyloid stimulates glial cells in vitro to produce growth factors that accumulate in senile plaques in Alzheimer's disease, Brain Res, vol.569, pp.141-145, 1992.

T. Asano and N. Ogasawara, Solubilization of the benzodiazepine receptor from rat brain, Life Sci, vol.26, pp.607-613, 1980.

T. Asano and S. Spector, Identification of inosine and hypoxanthine as endogenous ligands for the brain benzodiazepine-binding sites, Proc Natl Acad Sci U S A, vol.76, pp.977-981, 1979.

P. Assis-nascimento, K. M. Jarvis, J. R. Montague, and L. M. Mudd, Beta-amyloid toxicity in embryonic rat astrocytes, Neurochem Res, vol.32, pp.1476-1482, 2007.

R. Avallone, M. L. Zeneroli, and I. Venturini, Endogenous benzodiazepine-like compounds and diazepam binding inhibitor in serum of patients with liver cirrhosis with and without overt encephalopathy, Gut, vol.42, pp.861-867, 1998.

M. Awad and M. Gavish, Peripheral-type benzodiazepine receptors in human cerebral cortex, kidney, and colon, Life Sci, vol.49, pp.1155-1161, 1991.

T. Azuma, T. Matsubara, Y. Shima, S. Haeno, T. Fujimoto et al., Neurosteroids in cerebrospinal fluid in neurologic disorders, J Neurol Sci, vol.120, pp.87-92, 1993.

Y. S. Bae, H. Y. Lee, E. J. Jo, J. I. Kim, H. K. Kang et al., Identification of peptides that antagonize formyl peptide receptor-like 1-mediated signaling, J Immunol, vol.173, pp.607-614, 2004.

S. Baiguera, L. Fioravanzo, C. Grandi, R. Di-liddo, P. P. Parnigotto et al., Involvement of the receptor for advanced glycation-end products (RAGE) in beta-amyloid-induced toxic effects in rat cerebromicrovascular endothelial cells cultured in vitro, Int J Mol Med, vol.24, pp.9-15, 2009.

M. L. Barbaccia, E. Costa, P. Ferrero, A. Guidotti, A. Roy et al., Diazepam-binding inhibitor. A brain neuropeptide present in human spinal fluid: studies in depression, schizophrenia, and Alzheimer's disease, Arch Gen Psychiatry, vol.43, pp.1143-1147, 1986.

F. Bard, C. Cannon, and R. Barbour, Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease, Nat Med, vol.6, pp.916-919, 2000.

N. H. Barmack, T. R. Bilderback, H. Liu, Z. Qian, and V. Yakhnitsa, Activity-dependent expression of acyl-coenzyme a-binding protein in retinal muller glial cells evoked by optokinetic stimulation, J Neurosci, vol.24, pp.1023-1033, 2004.

E. C. Beattie, D. Stellwagen, W. Morishita, J. C. Bresnahan, B. K. Ha et al., Control of synaptic strength by glial TNFalpha, vol.295, pp.2282-2285, 2002.

E. L. Becker, F. A. Forouhar, and M. L. Grunnet, Broad immunocytochemical localization of the formylpeptide receptor in human organs, tissues, and cells, Cell Tissue Res, vol.292, pp.129-135, 1998.

F. Becq, Y. Hamon, A. Bajetto, M. Gola, B. Verrier et al., ABC1, an ATP binding cassette transporter required for phagocytosis of apoptotic cells, generates a regulated anion flux after expression in Xenopus laevis oocytes, J Biol Chem, vol.272, pp.2695-2699, 1997.

K. F. Bell, L. Zheng, F. Fahrenholz, and A. C. Cuello, ADAM-10 over-expression increases cortical synaptogenesis, Neurobiol Aging, vol.29, pp.554-565, 2008.

J. Benavides, B. Peny, D. Ruano, J. Vitorica, and B. Scatton, Comparative autoradiographic distribution of central omega (benzodiazepine) modulatory site subtypes with high, intermediate and low affinity for zolpidem and alpidem, Brain Res, vol.604, pp.240-250, 1993.

J. Benavides, D. Quarteronet, F. Imbault, C. Malgouris, A. Uzan et al., Labelling of "peripheral-type" benzodiazepine binding sites in the rat brain by using [3H]PK 11195, an isoquinoline carboxamide derivative: kinetic studies and autoradiographic localization, J Neurochem, vol.41, pp.1744-1750, 1983.

A. Berkovich, P. Mcphie, M. Campagnone, A. Guidotti, and P. Hensley, A natural processing product of rat diazepam binding inhibitor, triakontatetraneuropeptide (diazepam binding inhibitor 17-50) contains an alpha-helix, which allows discrimination between benzodiazepine binding site subtypes, Mol Pharmacol, vol.37, pp.164-172, 1990.

J. A. Berman, J. L. Roberts, and D. B. Pritchett, Molecular and pharmacological characterization of GABAA receptors in the rat pituitary, J Neurochem, vol.63, pp.1948-1954, 1994.

A. Betten, J. Bylund, T. Christophe, F. Boulay, A. Romero et al., A proinflammatory peptide from Helicobacter pylori activates monocytes to induce lymphocyte dysfunction and apoptosis, J Clin Invest, vol.108, pp.1221-1228, 2001.

P. Bezzi, M. Domercq, and L. Brambilla, CXCR4-activated astrocyte glutamate release via TNFalpha: amplification by microglia triggers neurotoxicity, Nat Neurosci, vol.4, pp.702-710, 2001.

P. Bezzi, V. Gundersen, J. L. Galbete, G. Seifert, C. Steinhauser et al., Astrocytes contain a vesicular compartment that is competent for regulated exocytosis of glutamate, Nat Neurosci, vol.7, pp.613-620, 2004.

J. Bhuiyan, P. H. Pritchard, S. V. Pande, and D. W. Seccombe, Effects of high-fat diet and fasting on levels of acyl-coenzyme A binding protein in liver, kidney, and heart of rat, Metabolism, vol.44, pp.1185-1189, 1995.

O. Blondel, C. Collin, W. J. Mccarran, S. Zhu, R. Zamostiano et al., A glia-derived signal regulating neuronal differentiation, J Neurosci, vol.20, pp.8012-8020, 2000.

P. Borboni, L. Condorelli, P. De-stefanis, G. Sesti, and R. Lauro, Modulation of insulin secretion by diazepam binding inhibitor and its processing products, Neuropharmacology, vol.30, pp.1399-1403, 1991.

J. Bormann, Electrophysiological characterization of diazepam binding inhibitor (DBI) on GABAA receptors, Neuropharmacology, vol.30, pp.1387-1389, 1991.

J. Bormann and H. Kettenmann, Patch-clamp study of gamma-aminobutyric acid receptor Clchannels in cultured astrocytes, Proc Natl Acad Sci U S A, vol.85, pp.9336-9340, 1988.

P. Bovolin, M. R. Santi, G. Puia, E. Costa, and D. Grayson, Expression patterns of gammaaminobutyric acid type A receptor subunit mRNAs in primary cultures of granule neurons and astrocytes from neonatal rat cerebella, Proc Natl Acad Sci, vol.89, pp.9344-9348, 1992.

C. Braestrup, R. Albrechtsen, and R. F. Squires, High densities of benzodiazepine receptors in human cortical areas, Nature, vol.269, pp.702-704, 1977.

C. Braestrup, M. Nielsen, and C. E. Olsen, Urinary and brain beta-carboline-3-carboxylates as potent inhibitors of brain benzodiazepine receptors, Proc Natl Acad Sci U S A, vol.77, pp.2288-2292, 1980.

C. Braestrup and R. F. Squires, Specific benzodiazepine receptors in rat brain characterized by high-affinity (3H)diazepam binding, Proc Natl Acad Sci U S A, vol.74, pp.3805-3809, 1977.

R. Brambilla, V. Bracchi-ricard, W. H. Hu, B. Frydel, A. Bramwell et al., Inhibition of astroglial nuclear factor kappaB reduces inflammation and improves functional recovery after spinal cord injury, J Exp Med, vol.202, pp.145-156, 2005.

L. O. Brandenburg, M. Konrad, C. Wruck, T. Koch, T. Pufe et al., Involvement of formyl-peptide-receptor-like-1 and phospholipase D in the internalization and signal transduction of amyloid beta 1-42 in glial cells, Neuroscience, vol.156, pp.266-276, 2008.

L. O. Brandenburg, M. Konrad, C. J. Wruck, T. Koch, R. Lucius et al., Functional and physical interactions between formyl-peptide-receptors and scavenger receptor MARCO and their involvement in amyloid beta 1-42-induced signal transduction in glial cells, J Neurochem, vol.113, pp.749-760, 2010.

B. Brera, A. Serrano, and M. L. De-ceballos, beta-amyloid peptides are cytotoxic to astrocytes in culture: a role for oxidative stress, Neurobiol Dis, vol.7, pp.395-405, 2000.

A. M. Brown, S. B. Tekkok, and B. R. Ransom, Glycogen regulation and functional role in mouse white matter, J Physiol, vol.549, pp.501-512, 2003.

A. S. Brown and P. F. Hall, Stimulation by endozepine of the side-chain cleavage of cholesterol in a reconstituted enzyme system, Biochem Biophys Res Commun, vol.180, pp.609-614, 1991.

R. C. Brown, B. Degenhardt, M. Kotoula, and V. Papadopoulous, Location-dependent role of the human glioma cell peripheral-type benzodiazepine receptor in proliferation and steroid biosynthesis, Cancer Lett, vol.156, pp.125-132, 2000.

R. C. Brown, Z. Han, C. Cascio, and V. Papadopoulos, Oxidative stress-mediated DHEA formation in Alzheimer's disease pathology, Neurobiol Aging, vol.24, pp.57-65, 2003.

M. Bureau, J. Laschet, M. Bureau-heeren, B. Hennuy, A. Minet et al., Astroglial cells express large amounts of GABAA receptor proteins in mature brain, J Neurochem, vol.65, 1995.

B. Burgi, W. Lichtensteiger, M. E. Lauber, and M. Schlumpf, Ontogeny of diazepam binding inhibitor/acyl-CoA binding protein mRNA and peripheral benzodiazepine receptor mRNA expression in the rat, J Neuroendocrinol, vol.11, pp.85-100, 1999.

J. D. Buxbaum, K. N. Liu, and Y. Luo, Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor, J Biol Chem, vol.273, pp.27765-27767, 1998.

J. Bylund, T. Christophe, F. Boulay, T. Nystrom, A. Karlsson et al., Proinflammatory activity of a cecropin-like antibacterial peptide from Helicobacter pylori, 2001.

, Antimicrob Agents Chemother, vol.45, pp.1700-1704

I. Caille, B. Allinquant, E. Dupont, C. Bouillot, A. Langer et al., Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone, Development, vol.131, pp.2173-2181, 2004.

X. Cao and T. C. Sudhof, A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60, Science, vol.293, pp.115-120, 2001.

J. L. Chang and H. J. Tsai, Carp cDNA sequence encoding a putative diazepam-binding inhibitor/endozepine/acyl-CoA-binding protein, Biochim Biophys Acta, vol.1298, pp.9-11, 1996.

J. Y. Chatton, L. Pellerin, and P. J. Magistretti, GABA uptake into astrocytes is not associated with significant metabolic cost: implications for brain imaging of inhibitory transmission, Proc Natl Acad Sci U S A, vol.100, pp.12456-12461, 2003.

S. J. Chen and H. D. Liu, Cloning and Sequencing of cDNA Encoding the Diazepam Binding Inhibitor (DBI), Sheng Wu, vol.30, pp.631-634, 1998.

X. Chen, D. Yang, W. Shen, H. F. Dong, J. M. Wang et al., Characterization of chenodeoxycholic acid as an endogenous antagonist of the G-coupled formyl peptide receptors, Inflamm Res, vol.49, pp.744-755, 2000.

Y. Chen, P. H. Chan, and R. A. Swanson, Astrocytes overexpressing Cu,Zn superoxide dismutase have increased resistance to oxidative injury, Glia, vol.33, pp.343-347, 2001.

Z. W. Chen, T. Bergman, and H. Jornvall, Full-length and N-terminally truncated chicken intestinal diazepam-binding inhibitor. Purification, structural characterization and influence on insulin release, Regul Pept, vol.69, pp.63-68, 1997.

P. Chomczynski and N. Sacchi, Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction, Anal Biochem, vol.162, pp.156-159, 1987.

R. H. Christie, M. Freeman, and B. T. Hyman, Expression of the macrophage scavenger receptor, a multifunctional lipoprotein receptor, in microglia associated with senile plaques in Alzheimer's disease, Am J Pathol, vol.148, pp.399-403, 1996.

T. Christophe, A. Karlsson, C. Dugave, M. J. Rabiet, F. Boulay et al., The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2, J Biol Chem, vol.276, pp.21585-21593, 2001.

N. Cinone, H. D. Hotje, and A. Carotti, Development of a unique 3D interaction model of endogenous and synthetic peripheral benzodiazepine receptor ligands, J Comput Aided Mol Des, vol.14, pp.753-768, 2000.

T. Clausen, Potassium and sodium transport and pH regulation, Can J Physiol Pharmacol, p.70, 1992.

A. Clow, V. Glover, I. Armando, and M. Sandler, New endogenous benzodiazepine receptor ligand in human urine: identity with endogenous monoamine oxidase inhibitor?, Life Sci, vol.33, pp.735-741, 1983.

S. Coco, F. Calegari, E. Pravettoni, D. Pozzi, E. Taverna et al., Storage and release of ATP from astrocytes in culture, J Biol Chem, vol.278, pp.1354-1362, 2003.

R. W. Collin, D. Van-strien, J. A. Leunissen, and G. J. Martens, Identification and expression of the first nonmammalian amyloid-beta precursor-like protein APLP2 in the amphibian Xenopus laevis, Eur J Biochem, vol.271, pp.1906-1912, 2004.

V. Compère, D. Lanfray, H. Castel, F. Morin, J. Leprince et al., Acute food deprivation reduces expression of diazepam-binding inhibitor, the precursor of the anorexigenic octadecaneuropeptide ODN, in mouse glial cells, J Mol Endocrinol, vol.44, pp.295-299, 2010.

V. Compère, S. Li, J. Leprince, M. C. Tonon, H. Vaudry et al., Effect of intracerebroventricular administration of the octadecaneuropeptide on the expression of proopiomelanocortin, neuropeptide Y and corticotropin-releasing hormone mRNAs in rat hypothalamus, J Neuroendocrinol, vol.15, pp.197-203, 2003.

V. Compère, S. Li, J. Leprince, M. C. Tonon, H. Vaudry et al., In vivo action of a new octadecaneuropeptide (ODN) antagonist on gonadotropin-releasing hormone gene expression in the male rat brain, Neuroscience, vol.125, pp.411-415, 2004.

V. Compère, S. Li, J. Leprince, M. C. Tonon, H. Vaudry et al., In vivo action of a new octadecaneuropeptide antagonist on neuropeptide Y and corticotropin-releasing hormone mRNA levels in rat, Brain Res Mol Brain Res, vol.141, pp.156-160, 2005.

V. Compère, J. Ouellet, V. Luu-the, B. Dureuil, M. C. Tonon et al., Role of androgens and glucocorticoids in the regulation of diazepam-binding inhibitor mRNA levels in male mouse hypothalamus, Brain Res, vol.1119, pp.50-57, 2006.

I. S. Coraci, J. Husemann, J. W. Berman, C. Hulette, J. H. Dufour et al., CD36, a class B scavenger receptor, is expressed 5pIpUHQFHV %LEOLRJUDSKLTXHV on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta-amyloid fibrils, Am J Pathol, vol.160, pp.101-112, 2002.

D. Corbett, J. Larsen, and K. D. Langdon, Diazepam delays the death of hippocampal CA1 neurons following global ischemia, Exp Neurol, vol.214, pp.309-314, 2008.

E. H. Corder, A. M. Saunders, and N. J. Risch, Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease, Nat Genet, vol.7, pp.180-184, 1994.

M. Cosentino, F. Marino, S. Cattaneo, L. Di-grazia, C. Francioli et al., Diazepam-binding inhibitor-derived peptides induce intracellular calcium changes and modulate human neutrophil function, J Leukoc Biol, vol.67, pp.637-643, 2000.

E. Costa, M. G. Corda, and A. Guidotti, On a brain polypeptide functioning as a putative effector for the recognition sites of benzodiazepine and beta-carboline derivatives, 1983.

, Neuropharmacology, vol.22, pp.1481-1492

Y. H. Cui, Y. Le, X. Zhang, W. Gong, K. Abe et al., Up-regulation of FPR2, a chemotactic receptor for amyloid beta 1-42 (A beta 42), in murine microglial cells by TNF alpha, Neurobiol Dis, vol.10, pp.366-377, 2002.

C. Dahlgren, T. Christophe, F. Boulay, P. N. Madianos, M. J. Rabiet et al., The synthetic chemoattractant Trp-Lys-Tyr-Met-Val-DMet activates neutrophils preferentially through the lipoxin A(4) receptor, Blood, vol.95, pp.1810-1818, 2000.

I. Daigle and C. Li, apl-1, a Caenorhabditis elegans gene encoding a protein related to the human beta-amyloid protein precursor, Proc Natl Acad Sci U S A, vol.90, pp.12045-12049, 1993.

C. J. De-haas, K. E. Veldkamp, A. Peschel, F. Weerkamp, W. J. Van-wamel et al., Chemotaxis inhibitory protein of Staphylococcus aureus, a bacterial antiinflammatory agent, J Exp Med, vol.199, pp.687-695, 2004.

J. G. De-mateos-verchere, J. Leprince, M. C. Tonon, H. Vaudry, and J. Costentin, The octadecaneuropeptide ODN induces anxiety in rodents: possible involvement of a shorter biologically active fragment, Peptides, vol.19, pp.841-848, 1998.
URL : https://hal.archives-ouvertes.fr/hal-01973042

J. G. De-mateos-verchere, J. Leprince, M. C. Tonon, H. Vaudry, and J. Costentin, The octadecaneuropeptide [diazepam-binding inhibitor (33-50)] exerts potent anorexigenic effects in rodents, Eur J Pharmacol, vol.414, pp.225-231, 2001.
URL : https://hal.archives-ouvertes.fr/hal-01973150

D. Souza, E. B. Anholt, R. R. Murphy, K. M. Snyder, S. H. Kuhar et al., Peripheral-type benzodiazepine receptors in endocrine organs: autoradiographic localization in rat pituitary, adrenal, and testis, Endocrinology, vol.116, pp.567-573, 1985.

P. De-stefanis, F. Impagnatiello, A. Berkovich, and A. Guidotti, Inhibitory effect of ODN, a naturally occurring processing product of diazepam binding inhibitor, on secretagogues-induced insulin secretion, Regul Pept, vol.56, pp.153-165, 1995.

Y. De, Q. Chen, A. P. Schmidt, G. M. Anderson, J. M. Wang et al., LL-37, the neutrophil granule-and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells, J Exp Med, vol.192, pp.1069-1074, 2000.

M. Dean and T. Annilo, Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebrates, Annu Rev Genomics Hum Genet, vol.6, pp.123-142, 2005.

M. A. Debernardi, R. R. Crowe, I. Mocchetti, T. B. Shows, R. L. Eddy et al., Chromosomal localization of the human diazepam binding inhibitor gene, Proc Natl Acad Sci U S A, vol.85, pp.6561-6565, 1988.

J. W. Deitmer and C. R. Rose, ) pH regulation and proton signalling by glial cells, Prog Neurobiol, vol.48, pp.73-103, 1996.

A. Delacourte and L. Buee, Tau pathology: a marker of neurodegenerative disorders, Curr Opin Neurol, vol.13, pp.371-376, 2000.

S. J. Dencker and G. Johansson, Benzodiazepine-like substances in mother's milk, Lancet, vol.335, p.413, 1990.

S. Desagher, J. Glowinski, and J. Premont, Astrocytes protect neurons from hydrogen peroxide toxicity, J Neurosci, vol.16, pp.2553-2562, 1996.

M. Desclaux, M. Teigell, L. Amar, R. Vogel, Y. R. Gimenez et al., A novel and efficient gene transfer strategy reduces glial reactivity and improves neuronal survival and axonal growth in vitro, PLoS One, vol.4, p.6227, 2009.

L. Desrues, M. C. Tonon, and H. Vaudry, Thyrotrophin-releasing hormone stimulates polyphosphoinositide metabolism in the frog neurointermediate lobe, J Mol Endocrinol, vol.5, pp.129-136, 1990.

J. L. Do-rego, A. G. Mensah-nyagan, D. Beaujean, J. Leprince, M. C. Tonon et al., The octadecaneuropeptide ODN stimulates neurosteroid biosynthesis through activation of central-type benzodiazepine receptors, J Neurochem, vol.76, pp.128-138, 2001.
URL : https://hal.archives-ouvertes.fr/hal-01962709

J. C. Do-rego, M. H. Orta, J. Leprince, M. C. Tonon, H. Vaudry et al., Pharmacological characterization of the receptor mediating the anorexigenic action of the octadecaneuropeptide: evidence for an endozepinergic tone regulating food intake, 2007.
URL : https://hal.archives-ouvertes.fr/hal-01962716

, Neuropsychopharmacology, vol.32, pp.1641-1648

M. Domercq, L. Brambilla, E. Pilati, J. Marchaland, A. Volterra et al., P2Y1 receptor-evoked glutamate exocytosis from astrocytes: control by tumor necrosis factor-alpha and prostaglandins, J Biol Chem, vol.281, pp.30684-30696, 2006.

E. Dong, K. Matsumoto, M. Tohda, and H. Watanabe, Involvement of diazepam binding inhibitor and its fragment octadecaneuropeptide in social isolation stress-induced decrease in pentobarbital sleep in mice, Life Sci, vol.64, pp.1779-1784, 1999.

Y. Dong and E. N. Benveniste, Immune function of astrocytes, Glia, vol.36, pp.180-190, 2001.

R. Dringen and B. Hamprecht, Involvement of glutathione peroxidase and catalase in the disposal of exogenous hydrogen peroxide by cultured astroglial cells, Brain Res, vol.759, pp.67-75, 1997.

R. Dringen, B. Pfeiffer, and B. Hamprecht, Synthesis of the antioxidant glutathione in neurons: supply by astrocytes of CysGly as precursor for neuronal glutathione, J Neurosci, vol.19, pp.562-569, 1999.

X. Duan, E. Kang, C. Y. Liu, G. L. Ming, and H. Song, Development of neural stem cell in the adult brain, Curr Opin Neurobiol, vol.18, pp.108-115, 2008.

G. E. Duncan, G. R. Breese, H. E. Criswell, T. J. Mccown, J. S. Herbert et al., Distribution of [3H]zolpidem binding sites in relation to messenger RNA encoding the alpha 1, beta 2 and gamma 2 subunits of GABAA receptors in rat brain, 1995.

, Neuroscience, vol.64, pp.1113-1128

C. Duparc, H. Lefebvre, M. C. Tonon, H. Vaudry, and J. M. Kuhn, Characterization of endozepines in the human testicular tissue: effect of triakontatetraneuropeptide on testosterone secretion, J Clin Endocrinol Metab, vol.88, pp.5521-5528, 2003.
URL : https://hal.archives-ouvertes.fr/hal-01928745

M. Durstin, J. L. Gao, H. L. Tiffany, D. Mcdermott, and P. M. Murphy, Differential expression of members of the N-formylpeptide receptor gene cluster in human phagocytes, 1994.

, Biochem Biophys Res Commun, vol.201, pp.174-179

C. Duyckaerts, M. C. Potier, and B. Delatour, Alzheimer disease models and human neuropathology: similarities and differences, Acta Neuropathol, vol.115, pp.5-38, 2008.
URL : https://hal.archives-ouvertes.fr/hal-00320572

C. B. Eckman and E. A. Eckman, An update on the amyloid hypothesis, Neurol Clin, vol.25, pp.669-682, 2007.

E. A. Eckman and C. B. Eckman, Abeta-degrading enzymes: modulators of Alzheimer's disease pathogenesis and targets for therapeutic intervention, Biochem Soc Trans, vol.33, pp.1101-1105, 2005.

M. Eddleston and L. Mucke, Molecular profile of reactive astrocytes--implications for their role in neurologic disease, Neuroscience, vol.54, pp.15-36, 1993.

F. J. Ekinci, K. U. Malik, and T. B. Shea, Activation of the L voltage-sensitive calcium channel by mitogen-activated protein (MAP) kinase following exposure of neuronal cells to betaamyloid. MAP kinase mediates beta-amyloid-induced neurodegeneration, J Biol Chem, vol.274, pp.30322-30327, 1999.

O. Elekes, K. Venema, F. Postema, R. Dringen, B. Hamprecht et al., Evidence that stress activates glial lactate formation in vivo assessed with rat hippocampus lactography, Neurosci Lett, vol.208, pp.69-72, 1996.

M. Elholm, G. Bjerking, J. Knudsen, K. Kristiansen, and S. Mandrup, Regulatory elements in the promoter region of the rat gene encoding the acyl-CoA-binding protein, Gene, vol.173, pp.233-238, 1996.

L. F. Eng, R. S. Ghirnikar, and Y. L. Lee, Glial fibrillary acidic protein: GFAP-thirty-one years, Neurochem Res, vol.25, pp.1439-1451, 1969.

N. J. Faergeman and J. Knudsen, Acyl-CoA binding protein is an essential protein in mammalian cell lines, Biochem J, vol.368, pp.679-682, 2002.

F. Fang, L. F. Lue, and S. Yan, RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease, Faseb J, vol.24, pp.1043-1055, 2010.

T. Fellin, Communication between neurons and astrocytes: relevance to the modulation of synaptic and network activity, J Neurochem, vol.108, pp.533-544, 2009.

C. Ferrarese, I. Appollonio, M. Frigo, S. Meregalli, R. Piolti et al., Cerebrospinal fluid levels of diazepam-binding inhibitor in neurodegenerative disorders with dementia, Neurology, vol.40, pp.632-635, 1990.

C. Ferrarese, T. Cogliati, and R. Tortorella, Diazepam binding inhibitor (DBI) in the plasma of pediatric and adult epileptic patients, Epilepsy Res, vol.29, pp.129-134, 1998.

C. Ferrarese, M. Perego, C. Marzorati, G. Bianchi, M. Frigo et al., Modifications of diazepam binding inhibitor and peripheral benzodiazepine receptors in the lymphocytes of epileptic patients, Ital J Neurol Sci, vol.17, pp.141-145, 1996.

C. Ferrarese, F. Vaccarino, H. Alho, B. Mellstrom, E. Costa et al., Subcellular location and neuronal release of diazepam binding inhibitor, J Neurochem, vol.48, pp.1093-1102, 1987.

A. Ferrero-gutierrez, A. Perez-gomez, A. Novelli, and M. T. Fernandez-sanchez, Inhibition of protein phosphatases impairs the ability of astrocytes to detoxify hydrogen peroxide, Free Radic Biol Med, vol.44, pp.1806-1816, 2008.

P. Ferrero, B. Conti-tronconi, and A. Guidotti, DBI, an anxiogenic neuropeptide found in human brain, Adv Biochem Psychopharmacol, vol.41, pp.177-185, 1986.

P. Ferrero, A. Guidotti, B. Conti-tronconi, and E. Costa, A brain octadecaneuropeptide generated by tryptic digestion of DBI (diazepam binding inhibitor) functions as a proconflict ligand of benzodiazepine recognition sites, Neuropharmacology, vol.23, pp.1359-1362, 1984.

P. Ferrero, P. Penna, F. Vischia, L. Tarenzi, B. Bergamasco et al., Diazepam binding inhibitor in brain and in cerebrospinal fluid of human, Ann Ist Super Sanita, vol.24, pp.443-459, 1988.

P. Ferrero, M. R. Santi, B. Conti-tronconi, E. Costa, and A. Guidotti, Study of an octadecaneuropeptide derived from diazepam binding inhibitor (DBI): biological activity and presence in rat brain, Proc Natl Acad Sci U S A, vol.83, pp.827-831, 1986.

R. J. Freer, A. R. Day, J. A. Radding, E. Schiffmann, S. Aswanikumar et al., Further studies on the structural requirements for synthetic peptide chemoattractants, Biochemistry, vol.19, pp.2404-2410, 1980.

N. Froger, J. A. Orellana, C. F. Calvo, E. Amigou, M. G. Kozoriz et al., Inhibition of cytokine-induced connexin43 hemichannel activity in astrocytes is neuroprotective, Mol Cell Neurosci, vol.45, pp.37-46, 2010.

R. L. Frozza, A. P. Horn, J. B. Hoppe, F. Simao, D. Gerhardt et al., A comparative study of beta-amyloid peptides Abeta1-42 and Abeta25-35 toxicity in organotypic hippocampal slice cultures, Neurochem Res, vol.34, pp.295-303, 2009.

H. Fu, L. Bjorkman, P. Janmey, A. Karlsson, J. Karlsson et al., The two neutrophil members of the formylpeptide receptor family activate the NADPH-oxidase through signals that differ in sensitivity to a gelsolin derived phosphoinositide-binding peptide, BMC Cell Biol, vol.5, 2004.

S. Galiegue, O. Jbilo, T. Combes, E. Bribes, P. Carayon et al., Cloning and characterization of PRAX-1. A new protein that specifically interacts with the peripheral benzodiazepine receptor, J Biol Chem, vol.274, pp.2938-2952, 1999.

D. W. Gallager, P. Mallorga, W. Oertel, R. Henneberry, and J. Tallman, 3H]Diazepam binding in mammalian central nervous system: a pharmacological characterization, J Neurosci, vol.1, pp.218-225, 1981.

P. Gandolfo, C. Patte, J. Leprince, J. L. Rego, A. G. Mensah-nyagan et al., The triakontatetraneuropeptide (TTN) stimulates thymidine incorporation in rat astrocytes through peripheral-type benzodiazepine receptors, J Neurochem, vol.75, pp.701-707, 2000.
URL : https://hal.archives-ouvertes.fr/hal-01962735

P. Gandolfo, C. Patte, J. Leprince, J. L. Thoumas, H. Vaudry et al., The stimulatory effect of the octadecaneuropeptide (ODN) on cytosolic Ca2+ in rat astrocytes is not mediated through classical benzodiazepine receptors, Eur J Pharmacol, vol.322, pp.275-281, 1997.
URL : https://hal.archives-ouvertes.fr/hal-01962733

P. Gandolfo, C. Patte, J. L. Thoumas, J. Leprince, H. Vaudry et al., The endozepine ODN stimulates, 1999.
URL : https://hal.archives-ouvertes.fr/hal-01962734

, Neuropharmacology, vol.38, pp.725-732

J. Garcia-de-mateos-verchere, J. Leprince, M. C. Tonon, H. Vaudry, and J. Costentin, The octadecaneuropeptide ODN inhibits apomorphine-induced yawning in rats, Eur J Pharmacol, vol.357, pp.121-126, 1998.
URL : https://hal.archives-ouvertes.fr/hal-01973047

M. Garnier, N. Boujrad, S. O. Ogwuegbu, J. R. Hudson, J. Papadopoulos et al., The polypeptide diazepam-binding inhibitor and a higher affinity mitochondrial peripheral-type benzodiazepine receptor sustain constitutive steroidogenesis in the R2C Leydig tumor cell line, J Biol Chem, vol.269, pp.22105-22112, 1994.

M. Garnier, N. Boujrad, B. O. Oke, A. S. Brown, J. Riond et al., Diazepam binding inhibitor is a paracrine/autocrine regulator of Leydig cell proliferation and steroidogenesis: action via peripheral-type benzodiazepine receptor and independent mechanisms, Endocrinology, vol.132, pp.444-458, 1993.

M. Garnier, A. B. Dimchev, N. Boujrad, J. M. Price, N. A. Musto et al., In vitro reconstitution of a functional peripheral-type benzodiazepine receptor from mouse Leydig tumor cells, Mol Pharmacol, vol.45, pp.201-211, 1994.

V. H. Gersuk, T. M. Rose, and G. J. Todaro, Molecular cloning and chromosomal localization of a pseudogene related to the human acyl-CoA binding protein/diazepam binding inhibitor, 1995.

, Genomics, vol.25, pp.469-476

D. Giulian, L. J. Haverkamp, J. Li, W. L. Karshin, J. Yu et al., Senile plaques stimulate microglia to release a neurotoxin found in Alzheimer brain, Neurochem Int, vol.27, pp.119-137, 1995.

L. Givalois, V. Grinevich, S. Li, E. Garcia-de-yebenes, and G. Pelletier, The octadecaneuropeptide-induced response of corticotropin-releasing hormone messenger RNA levels is mediated by GABA(A) receptors and modulated by endogenous steroids, Neuroscience, vol.85, pp.557-567, 1998.
URL : https://hal.archives-ouvertes.fr/hal-01923615

G. G. Glenner and C. W. Wong, Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein, Biochem Biophys Res Commun, vol.120, pp.885-890, 1984.

V. Glover, I. Armando, A. Clow, and M. Sandler, Endogenous urinary monoamine oxidase inhibitor: the benzodiazepine connection, Mod Probl Pharmacopsychiatry, vol.19, pp.118-125, 1983.

A. Goate, Segregation of a missense mutation in the amyloid beta-protein precursor gene with familial Alzheimer's disease, J Alzheimers Dis, vol.9, pp.341-347, 2006.

E. J. Goetzl, D. W. Foster, and D. W. Goldman, Isolation and partial characterization of membrane protein constituents of human neutrophil receptors for chemotactic formylmethionyl peptides, Biochemistry, vol.20, pp.5717-5722, 1981.

Y. Goodman and M. P. Mattson, Secreted forms of beta-amyloid precursor protein protect hippocampal neurons against amyloid beta-peptide-induced oxidative injury, Exp Neurol, vol.128, pp.1-12, 1994.

F. Granucci, F. Petralia, M. Urbano, S. Citterio, F. Di-tota et al., The scavenger receptor MARCO mediates cytoskeleton rearrangements in dendritic cells and microglia, Blood, vol.102, pp.2940-2947, 2003.

P. W. Gray, D. Glaister, P. H. Seeburg, A. Guidotti, and E. Costa, Cloning and expression of cDNA for human diazepam binding inhibitor, a natural ligand of an allosteric regulatory site of the gamma-aminobutyric acid type A receptor, Proc Natl Acad Sci U S A, vol.83, pp.7547-7551, 1986.

P. Guarneri, A. Berkovich, A. Guidotti, and E. Costa, A study of diazepam binding inhibitor (DBI) processing products in human cerebrospinal fluid and in postmortem human brain, 1990.

, Neuropharmacology, vol.29, pp.419-428

C. Guerrero, M. Martin-rufian, J. J. Reina, and A. Heredia, Isolation and characterization of a cDNA encoding a membrane bound acyl-CoA binding protein from Agave americana L. epidermis, Plant Physiol Biochem, vol.44, pp.85-90, 2006.

A. Guidotti, Role of DBI in brain and its posttranslational processing products in normal and abnormal behavior, Neuropharmacology, vol.30, pp.1425-1433, 1991.

A. Guidotti, M. G. Corda, and E. Costa, Strategies for the isolation and characterization of an endogenous effector of the benzodiazepine recognition sites, Adv Biochem Psychopharmacol, vol.38, pp.95-103, 1983.

A. Guidotti, C. M. Forchetti, M. G. Corda, D. Konkel, C. D. Bennett et al., Isolation, characterization, and purification to homogeneity of an endogenous polypeptide with agonistic action on benzodiazepine receptors, Proc Natl Acad Sci U S A, vol.80, pp.3531-3535, 1983.

B. Gulyas, B. Makkai, and P. Kasa, A comparative autoradiography study in post mortem whole hemisphere human brain slices taken from Alzheimer patients and age-matched controls using two radiolabelled DAA1106 analogues with high affinity to the peripheral benzodiazepine receptor (PBR) system, Neurochem Int, vol.54, pp.28-36, 2009.

K. L. Hadingham, E. M. Garrett, K. A. Wafford, C. Bain, R. P. Heavens et al., Cloning of cDNAs encoding the human gamma-aminobutyric acid type A receptor alpha 6 subunit and characterization of the pharmacology of alpha 6-containing receptors, 1996.

, Mol Pharmacol, vol.49, pp.253-259

M. M. Halassa and P. G. Haydon, Integrated brain circuits: astrocytic networks modulate neuronal activity and behavior, Annu Rev Physiol, vol.72, pp.335-355, 2010.

M. E. Hamby, J. A. Hewett, and S. J. Hewett, TGF-beta1 potentiates astrocytic nitric oxide production by expanding the population of astrocytes that express NOS-2, Glia, vol.54, pp.566-577, 2006.

Y. Hamon, M. F. Luciani, F. Becq, B. Verrier, A. Rubartelli et al., Interleukin1beta secretion is impaired by inhibitors of the Atp binding cassette transporter, ABC1. Blood, vol.90, pp.2911-2915, 1997.

H. O. Hansen, P. H. Andreasen, S. Mandrup, K. Kristiansen, and J. Knudsen, Induction of acyl-CoA-binding protein and its mRNA in 3T3-L1 cells by insulin during preadipocyte-toadipocyte differentiation, Biochem J, pp.341-344, 1991.

J. S. Hansen, N. J. Faergeman, B. B. Kragelund, and J. Knudsen, Acyl-CoA-binding protein (ACBP) localizes to the endoplasmic reticulum and Golgi in a ligand-dependent manner in mammalian cells, Biochem J, vol.410, pp.463-472, 2008.

H. Harada, A. Tamaoka, K. Ishii, S. Shoji, S. Kametaka et al., Beta-site APP cleaving enzyme, vol.1, 2006.

, Alzheimer's disease brains, Neurosci Res, vol.54, pp.24-29

M. Harada, Y. Habata, M. Hosoya, K. Nishi, R. Fujii et al., NFormylated humanin activates both formyl peptide receptor-like 1 and 2, Biochem Biophys Res Commun, vol.324, pp.255-261, 2004.

M. Hardwick, D. Fertikh, M. Culty, H. Li, B. Vidic et al., Peripheral-type benzodiazepine receptor (PBR) in human breast cancer: correlation of breast cancer cell aggressive phenotype with PBR expression, nuclear localization, and PBR-mediated cell proliferation and nuclear transport of cholesterol, Cancer Res, vol.59, pp.831-842, 1999.

C. Henneberger, T. Papouin, S. H. Oliet, and D. A. Rusakov, Long-term potentiation depends on release of D-serine from astrocytes, Nature, vol.463, pp.232-236, 2010.

M. Hernandez-guillamon, P. Delgado, and L. Ortega, Neuronal TIMP-1 release accompanies astrocytic MMP-9 secretion and enhances astrocyte proliferation induced by betaamyloid 25-35 fragment, J Neurosci Res, vol.87, pp.2115-2125, 2009.

J. E. Herrmann, T. Imura, and B. Song, STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury, J Neurosci, vol.28, pp.7231-7243, 2008.

K. H. Herzig, Cholecystokinin-and secretin-releasing peptides in the intestine--a new regulatory interendocrine mechanism in the gastrointestinal tract, Regul Pept, vol.73, pp.89-94, 1998.

K. H. Herzig, I. Schon, K. Tatemoto, Y. Ohe, Y. Li et al., , 1996.

, Diazepam binding inhibitor is a potent cholecystokinin-releasing peptide in the intestine, Proc Natl Acad Sci, pp.7927-7932

W. Hevers and H. Luddens, The diversity of GABAA receptors. Pharmacological and electrophysiological properties of GABAA channel subtypes, Mol Neurobiol, vol.18, pp.35-86, 1998.

S. E. Hickman, E. K. Allison, and J. Khoury, Microglial dysfunction and defective betaamyloid clearance pathways in aging Alzheimer's disease mice, J Neurosci, vol.28, pp.8354-8360, 2008.

K. Hirano, S. Yamashita, and Y. Nakagawa, Expression of human scavenger receptor class B type I in cultured human monocyte-derived macrophages and atherosclerotic lesions, Circ Res, vol.85, pp.108-116, 1999.

E. Hirsch, V. L. Katanaev, and C. Garlanda, Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation, Science, vol.287, pp.1049-1053, 2000.

R. K. Hopper, S. Carroll, A. M. Aponte, D. T. Johnson, S. French et al., Mitochondrial matrix phosphoproteome: effect of extra mitochondrial calcium, Biochemistry, vol.45, pp.2524-2536, 2006.

L. Hu, J. T. Deeney, and C. J. Nolan, Regulation of lipolytic activity by long-chain acylcoenzyme A in islets and adipocytes, Am J Physiol Endocrinol Metab, vol.289, pp.1085-1092, 2005.

H. Huang, B. P. Atshaves, A. Frolov, A. B. Kier, and F. Schroeder, Acyl-coenzyme A binding protein expression alters liver fatty acyl-coenzyme A metabolism, Biochemistry, vol.44, pp.10282-10297, 2005.

J. Husemann, J. D. Loike, R. Anankov, M. Febbraio, and S. C. Silverstein, Scavenger receptors in neurobiology and neuropathology: their role on microglia and other cells of the nervous system, Glia, vol.40, pp.195-205, 2002.

J. Husemann and S. C. Silverstein, Expression of scavenger receptor class B, type I, by astrocytes and vascular smooth muscle cells in normal adult mouse and human brain and in Alzheimer's disease brain, Am J Pathol, vol.158, pp.825-832, 2001.

K. Iijima, D. S. Lee, J. Okutsu, S. Tomita, N. Hirashima et al., cDNA isolation of Alzheimer's amyloid precursor protein from cholinergic nerve terminals of the electric organ of the electric ray, Biochem J, vol.330, pp.29-33, 1998.

B. P. Imbimbo, Therapeutic potential of gamma-secretase inhibitors and modulators, Curr Top Med Chem, vol.8, pp.54-61, 2008.

M. Inazu, H. Takeda, and T. Matsumiya, Expression and functional characterization of the extraneuronal monoamine transporter in normal human astrocytes, J Neurochem, vol.84, pp.43-52, 2003.

A. Ishida, K. Furukawa, J. N. Keller, and M. P. Mattson, Secreted form of beta-amyloid precursor protein shifts the frequency dependency for induction of LTD, and enhances LTP in hippocampal slices, Neuroreport, vol.8, pp.2133-2137, 1997.

Y. Itzhak, L. Baker, and M. D. Norenberg, Characterization of the peripheral-type benzodiazepine receptors in cultured astrocytes: evidence for multiplicity, Glia, vol.9, pp.211-218, 1993.

R. Ivell, W. Pusch, M. Balvers, M. Valentin, N. Walther et al., Progressive inactivation of the haploid expressed gene for the sperm-specific endozepine-like peptide (ELP) through primate evolution, Gene, vol.255, pp.335-345, 2000.

J. T. Jarrett, E. P. Berger, P. T. Lansbury, and . Jr, The C-terminus of the beta protein is critical in amyloidogenesis, Ann N Y Acad Sci, vol.695, pp.144-148, 1993.

K. A. Jellinger, Head injury and dementia, Curr Opin Neurol, vol.17, pp.719-723, 2004.

E. C. Jenkins, E. A. Devine-gage, and N. K. Robakis, Fine mapping of an Alzheimer disease-associated gene encoding beta-amyloid protein, Biochem Biophys Res Commun, vol.151, pp.1-8, 1988.

G. R. John, S. C. Lee, and C. F. Brosnan, Cytokines: powerful regulators of glial cell activation, Neuroscientist, vol.9, pp.10-22, 2003.

P. Jourdain, L. H. Bergersen, and K. Bhaukaurally, Glutamate exocytosis from astrocytes controls synaptic strength, Nat Neurosci, vol.10, pp.331-339, 2007.

A. A. Juknat, V. Mendez-mdel, A. Quaglino, C. I. Fameli, M. Mena et al., Melatonin prevents hydrogen peroxide-induced Bax expression in cultured rat astrocytes, J Pineal Res, vol.38, pp.84-92, 2005.

B. L. Kagan, Y. Hirakura, R. Azimov, R. Azimova, and M. C. Lin, The channel hypothesis of Alzheimer's disease: current status, Peptides, vol.23, pp.1311-1315, 2002.

A. Y. Kam, T. T. Tse, D. H. Kwan, and Y. H. Wong, Formyl peptide receptor like 1 differentially requires mitogen-activated protein kinases for the induction of glial fibrillary acidic protein and interleukin-1alpha in human U87 astrocytoma cells, Cell Signal, vol.19, pp.2106-2117, 2007.

J. Kang, H. G. Lemaire, A. Unterbeck, J. M. Salbaum, C. L. Masters et al., The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor, Nature, vol.325, pp.733-736, 1987.

J. Kang and B. Muller-hill, Differential splicing of Alzheimer's disease amyloid A4 precursor RNA in rat tissues: PreA4(695) mRNA is predominantly produced in rat and human brain, 1990.

, Biochem Biophys Res Commun, vol.166, pp.1192-1200

K. Katsura, T. Kristian, R. Nair, and B. K. Siesjo, Regulation of intra-and extracellular pH in the rat brain in acute hypercapnia: a re-appraisal, Brain Res, vol.651, pp.47-56, 1994.

M. Katsura, A. Hara, A. Higo, C. Tarumi, Y. Hibino et al., Continuous treatment with morphine increases diazepam binding inhibitor mRNA in mouse brain, J Neurochem, vol.71, pp.2638-2641, 1998.

M. Katsura, S. Ohkuma, X. Jun, A. Tsujimura, and K. Kuriyama, Ethanol stimulates diazepam binding inhibitor (DBI) mRNA expression in primary cultured neurons, Brain Res Mol Brain Res, vol.34, pp.355-359, 1995.

M. Katsura, S. Ohkuma, A. Tsujimura, and K. Kuriyama, Increase of diazepam binding inhibitor mRNA levels in the brains of chronically ethanol-treated and -withdrawn mice, J Pharmacol Exp Ther, vol.273, pp.1529-1533, 1995.

M. Kavaliers and M. Hirst, An octadecaneuropeptide (ODN) derived from diazepam binding inhibitor increases aggressive interactions in mice, Brain Res, vol.383, pp.343-349, 1986.

M. Kawahara and Y. Kuroda, Molecular mechanism of neurodegeneration induced by Alzheimer's beta-amyloid protein: channel formation and disruption of calcium homeostasis, Brain Res Bull, vol.53, pp.389-397, 2000.

Z. U. Khan, A. Gutierrez, A. K. Mehta, C. P. Miralles, and A. L. De-blas, The alpha 4 subunit of the GABAA receptors from rat brain and retina, Neuropharmacology, vol.35, pp.1315-1322, 1996.

C. H. Kim, S. I. Han, and S. Y. Lee, Protein kinase C-ERK1/2 signal pathway switches glucose depletion-induced necrosis to apoptosis by regulating superoxide dismutases and suppressing reactive oxygen species production in A549 lung cancer cells, J Cell Physiol, vol.211, pp.371-385, 2007.

W. S. Kim, G. J. Guillemin, E. N. Glaros, C. K. Lim, and B. Garner, Quantitation of ATPbinding cassette subfamily-A transporter gene expression in primary human brain cells, Neuroreport, vol.17, pp.891-896, 2006.

Y. Kim, B. D. Lee, O. Kim, Y. S. Bae, T. Lee et al., Pituitary adenylate cyclase-activating polypeptide 27 is a functional ligand for formyl peptide receptor-like, 2006.

, J Immunol, vol.176, pp.2969-2975

U. Klotz, Occurrence of "natural" benzodiazepines, Life Sci, vol.48, pp.209-215, 1991.

J. Knudsen, N. J. Faergeman, and H. Skott, Yeast acyl-CoA-binding protein: acyl-CoAbinding affinity and effect on intracellular acyl-CoA pool size, Biochem J, vol.302, pp.479-485, 1994.

M. Koistinaho, S. Lin, and X. Wu, Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides, Nat Med, vol.10, pp.719-726, 2004.

S. Koizumi, Synchronization of Ca2+ oscillations: involvement of ATP release in astrocytes, Febs J, vol.277, pp.286-292, 2010.

M. Kolmer, H. Alho, E. Costa, and L. Pani, Cloning and tissue-specific functional characterization of the promoter of the rat diazepam binding inhibitor, a peptide with multiple biological actions, Proc Natl Acad Sci U S A, vol.90, pp.8439-8443, 1993.

M. Kolmer, C. Roos, M. Tirronen, S. Myohanen, and H. Alho, Tissue-specific expression of the diazepam-binding inhibitor in Drosophila melanogaster: cloning, structure, and localization of the gene, Mol Cell Biol, vol.14, pp.6983-6995, 1994.

M. Kolmer, A. Rovio, and H. Alho, The characterization of two diazepam binding inhibitor (DBI) transcripts in humans, Biochem J, vol.306, pp.327-330, 1995.

V. M. Korkhov, C. Sachse, J. M. Short, and C. G. Tate, Three-dimensional structure of TspO by electron cryomicroscopy of helical crystals, Structure, vol.18, pp.677-687, 2010.

B. B. Kragelund, K. Poulsen, and K. V. Andersen, Conserved residues and their role in the structure, function, and stability of acyl-coenzyme A binding protein, Biochemistry, vol.38, pp.2386-2394, 1999.

M. Krieger and J. Herz, Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related protein (LRP), Annu Rev Biochem, vol.63, pp.601-637, 1994.

K. E. Krueger and V. Papadopoulos, Peripheral-type benzodiazepine receptors mediate translocation of cholesterol from outer to inner mitochondrial membranes in adrenocortical cells, J Biol Chem, vol.265, pp.15015-15022, 1990.

T. Kubo, S. Nishimura, Y. Kumagae, and I. Kaneko, In vivo conversion of racemized betaamyloid ([D-Ser 26]A beta 1-40) to truncated and toxic fragments ([D-Ser 26]A beta 25-35/40) and fragment presence in the brains of Alzheimer's patients, J Neurosci Res, vol.70, pp.474-483, 2002.

A. C. Kuhlmann and T. R. Guilarte, Cellular and subcellular localization of peripheral benzodiazepine receptors after trimethyltin neurotoxicity, J Neurochem, vol.74, pp.1694-1704, 2000.

M. G. Kushner, K. J. Sher, and B. D. Beitman, The relation between alcohol problems and the anxiety disorders, Am J Psychiatry, vol.147, pp.685-695, 1990.

J. J. Lacapère and V. Papadopoulos, Peripheral-type benzodiazepine receptor: structure and function of a cholesterol-binding protein in steroid and bile acid biosynthesis, Steroids, vol.68, pp.569-585, 2003.

P. Lacor, J. Benavides, and B. Ferzaz, Enhanced expression of the peripheral benzodiazepine receptor (PBR) and its endogenous ligand octadecaneuropeptide (ODN) in the regenerating adult rat sciatic nerve, Neurosci Lett, vol.220, pp.61-65, 1996.

P. Lacor, P. Gandolfo, M. C. Tonon, E. Brault, I. Dalibert et al., Regulation of the expression of peripheral benzodiazepine receptors and their endogenous ligands during rat sciatic nerve degeneration and regeneration: a role for PBR in neurosteroidogenesis, Brain Res, vol.815, pp.70-80, 1999.

M. Lacy, J. Jones, S. R. Whittemore, D. L. Haviland, R. A. Wetsel et al., Expression of the receptors for the C5a anaphylatoxin, interleukin-8 and FMLP by human astrocytes and microglia, J Neuroimmunol, vol.61, pp.71-78, 1995.

F. M. Laferla, K. N. Green, and S. Oddo, Intracellular amyloid-beta in Alzheimer's disease, Nat Rev Neurosci, vol.8, pp.499-509, 2007.

M. Lamacz, M. C. Tonon, F. Smih-rouet, C. Patte, P. Gasque et al., The endogenous benzodiazepine receptor ligand ODN increases cytosolic calcium in cultured rat astrocytes, Brain Res Mol Brain Res, vol.37, pp.290-296, 1996.

J. C. Lambert and P. Amouyel, Genetic heterogeneity of Alzheimer's disease: complexity and advances, Psychoneuroendocrinology, vol.32, issue.1, pp.62-70, 2007.

J. J. Lambert, D. Belelli, C. Hill-venning, and J. A. Peters, Neurosteroids and GABAA receptor function, Trends Pharmacol Sci, vol.16, pp.295-303, 1995.

N. C. Lan and K. W. Gee, Neuroactive steroid actions at the GABAA receptor, Horm Behav, vol.28, pp.537-544, 1994.

D. J. Laurie, P. H. Seeburg, and W. Wisden, The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. II. Olfactory bulb and cerebellum, J Neurosci, vol.12, pp.1063-1076, 1992.

Y. Le, W. Gong, B. Li, N. M. Dunlop, W. Shen et al., Utilization of two seven-transmembrane, G protein-coupled receptors, formyl peptide receptor-like 1 and formyl peptide receptor, by the synthetic hexapeptide WKYMVm for human phagocyte activation, J Immunol, vol.163, pp.6777-6784, 1999.

Y. Le, W. Gong, and H. L. Tiffany, Amyloid (beta)42 activates a G-protein-coupled chemoattractant receptor, FPR-like-1, J Neurosci, vol.21, p.123, 2001.

Y. Le, J. Hu, W. Gong, W. Shen, B. Li et al., Expression of functional formyl peptide receptors by human astrocytoma cell lines, J Neuroimmunol, vol.111, pp.102-108, 2000.

Y. Le, P. M. Murphy, and J. M. Wang, Formyl-peptide receptors revisited, Trends Immunol, vol.23, pp.541-548, 2002.

Y. Le, J. J. Oppenheim, and J. M. Wang, Pleiotropic roles of formyl peptide receptors, Cytokine Growth Factor Rev, vol.12, pp.91-105, 2001.

Y. Le, H. Yazawa, W. Gong, Z. Yu, V. J. Ferrans et al., The neurotoxic prion peptide fragment PrP(106-126) is a chemotactic agonist for the G protein-coupled receptor formyl peptide receptor-like 1, J Immunol, vol.166, pp.1448-1451, 2001.

L. Lee, C. A. Debono, D. R. Campagna, D. C. Young, D. B. Moody et al., Loss of the acyl-CoA binding protein (Acbp) results in fatty acid metabolism abnormalities in mouse hair and skin, J Invest Dermatol, vol.127, pp.16-23, 2007.

J. Leprince, D. Cosquer, G. Bellemere, D. Chatenet, H. Tollemer et al., Catabolism of the octadecaneuropeptide ODN by prolyl endopeptidase: identification of an unusual cleavage site, Peptides, vol.27, pp.1561-1569, 2006.
URL : https://hal.archives-ouvertes.fr/hal-01972591

J. Leprince, P. Gandolfo, J. L. Thoumas, C. Patte, J. L. Fauchere et al., Structure-activity relationships of a series of analogues of the octadecaneuropeptide ODN on calcium mobilization in rat astrocytes, J Med Chem, vol.41, pp.4433-4438, 1998.
URL : https://hal.archives-ouvertes.fr/hal-01972548

J. Leprince, H. Oulyadi, and D. Vaudry, Synthesis, conformational analysis and biological activity of cyclic analogs of the octadecaneuropeptide ODN. Design of a potent endozepine antagonist, Eur J Biochem, vol.268, pp.6045-6057, 2001.
URL : https://hal.archives-ouvertes.fr/hal-01972542

O. Lesouhaitier, M. Feuilloley, and H. Vaudry, Effect of the triakontatetraneuropeptide (TTN) on corticosteroid secretion by the frog adrenal gland, J Mol Endocrinol, vol.20, pp.45-53, 1998.

O. Lesouhaitier, M. K. Kodjo, F. Cartier, V. Contesse, L. Yon et al., The effect of the endozepine triakontatetraneuropeptide on corticosteroid secretion by the frog adrenal gland is mediated by activation of adenylyl cyclase and calcium influx through T-type calcium channels, Endocrinology, vol.141, pp.197-207, 2000.

K. C. Leung, H. Y. Li, G. Mishra, and M. L. Chye, ACBP4 and ACBP5, novel Arabidopsis acyl-CoA-binding proteins with kelch motifs that bind oleoyl-CoA, Plant Mol Biol, vol.55, pp.297-309, 2004.

E. Levy-lahad, E. M. Wijsman, E. Nemens, L. Anderson, K. A. Goddard et al., A familial Alzheimer's disease locus on chromosome 1, Science, vol.269, pp.970-973, 1995.

H. Li, B. Degenhardt, D. Tobin, Z. X. Yao, K. Tasken et al., Identification, localization, and function in steroidogenesis of PAP7: a peripheral-type benzodiazepine receptorand PKA (RIalpha)-associated protein, Mol Endocrinol, vol.15, pp.2211-2228, 2001.

S. Li and G. Pelletier, Inhibitory effect of the potential endogenous benzodiazepine receptor ligand, octadecaneuropeptide (ODN), on gonadotropin-releasing hormone gene expression in the male rat brain, Neuroreport, vol.6, pp.1354-1356, 1995.

Y. S. Li, P. Wu, and X. Y. Zhou, Formyl-peptide receptor like 1: a potent mediator of the Ca2+ release-activated Ca2+ current ICRAC, Arch Biochem Biophys, vol.478, pp.110-118, 2008.

T. S. Liang, J. L. Gao, O. Fatemi, M. Lavigne, T. L. Leto et al., The endogenous opioid spinorphin blocks fMet-Leu-Phe-induced neutrophil chemotaxis by acting as a specific antagonist at the N-formylpeptide receptor subtype FPR, J Immunol, vol.167, pp.6609-6614, 2001.

T. S. Liang, J. M. Wang, P. M. Murphy, and J. L. Gao, Serum amyloid A is a chemotactic agonist at FPR2, a low-affinity N-formylpeptide receptor on mouse neutrophils, Biochem Biophys Res Commun, vol.270, pp.331-335, 2000.

I. Lihrmann, J. C. Plaquevent, H. Tostivint, R. Raijmakers, M. C. Tonon et al., Frog diazepam-binding inhibitor: peptide sequence, cDNA cloning, and expression in the brain, Proc Natl Acad Sci U S A, vol.91, pp.6899-6903, 1994.

J. Liu, L. R. Cavalli, B. R. Haddad, and V. Papadopoulos, Molecular cloning, genomic organization, chromosomal mapping and subcellular localization of mouse PAP7: a PBR and PKARIalpha associated protein, Gene, vol.308, pp.1-10, 2003.

J. Liu, L. Matyakhina, Z. Han, F. Sandrini, T. Bei et al., Molecular cloning, chromosomal localization of human peripheral-type benzodiazepine receptor and PKA regulatory subunit type 1A (PRKAR1A)-associated protein PAP7, and studies in PRKAR1A mutant cells and tissues, Faseb J, vol.17, pp.1189-1191, 2003.

M. Liu, T. Y. Zhang, and W. H. Xu, A cDNA encoding diazepam-binding inhibitor/acyl-CoAbinding protein in Helicoverpa armigera: molecular characterization and expression analysis associated with pupal diapause, Comp Biochem Physiol C Toxicol Pharmacol, vol.141, pp.168-176, 2005.

D. Lorton, J. M. Kocsis, L. King, K. Madden, and K. R. Brunden, beta-Amyloid induces increased release of interleukin-1 beta from lipopolysaccharide-activated human monocytes, J Neuroimmunol, vol.67, pp.21-29, 1996.

E. Louiset, H. Vaudry, and L. Cazin, Allosteric modulation of the GABA-induced chloride current in frog melanotrophs, Ann N Y Acad Sci, vol.680, pp.564-566, 1993.

S. Luchetti, K. Bossers, S. Van-de-bilt, V. Agrapart, R. R. Morales et al., Neurosteroid biosynthetic pathways changes in prefrontal cortex in Alzheimer's disease, Neurobiol Aging, 2009.

L. F. Lue, D. G. Walker, L. Brachova, T. G. Beach, J. Rogers et al., Involvement of microglial receptor for advanced glycation endproducts (RAGE) in Alzheimer's disease: identification of a cellular activation mechanism, Exp Neurol, vol.171, pp.29-45, 2001.

R. B. Maccioni and V. Cambiazo, Role of microtubule-associated proteins in the control of microtubule assembly, Physiol Rev, vol.75, pp.835-864, 1995.

T. K. Makar, M. Nedergaard, A. Preuss, A. S. Gelbard, A. S. Perumal et al., , 1994.

E. Vitamin, and enzymes of glutathione metabolism in cultures of chick astrocytes and neurons: evidence that astrocytes play an important role in antioxidative processes in the brain, J Neurochem, vol.62, pp.45-53

M. Malagon, H. Vaudry, F. Van-strien, G. Pelletier, F. Gracia-navarro et al., Ontogeny of diazepam-binding inhibitor-related peptides (endozepines) in the rat brain, Neuroscience, vol.57, pp.777-786, 1993.

Y. Manabe, T. Toyoda, K. Kuroda, M. Imaizumi, T. Yamamoto et al., Effect of diazepam binding inhibitor (DBI) on the fluid intake, preference and the taste reactivity in mice, Behav Brain Res, vol.126, pp.197-204, 2001.

S. Mandrup, R. Hummel, S. Ravn, G. Jensen, P. H. Andreasen et al., Acyl-CoA-binding protein/diazepam-binding inhibitor gene and pseudogenes. A typical housekeeping gene family, J Mol Biol, vol.228, pp.1011-1022, 1992.

S. Mandrup, R. V. Sorensen, T. Helledie, J. Nohr, T. Baldursson et al., Inhibition of 3T3-L1 adipocyte differentiation by expression of acyl-CoAbinding protein antisense RNA, J Biol Chem, vol.273, pp.23897-23903, 1998.

P. J. Marangos, J. Patel, J. P. Boulenger, and R. Clark-rosenberg, Characterization of peripheral-type benzodiazepine binding sites in brain using [3H]Ro 5-4864, Mol Pharmacol, vol.22, pp.26-32, 1982.

W. A. Marasco, J. C. Fantone, R. J. Freer, and P. A. Ward, Characterization of the rat neutrophil formyl peptide chemotaxis receptor, Am J Pathol, vol.111, pp.273-281, 1983.

W. A. Marasco, S. H. Phan, H. Krutzsch, H. J. Showell, D. E. Feltner et al., Purification and identification of formyl-methionyl-leucyl-phenylalanine as the major peptide neutrophil chemotactic factor produced by Escherichia coli, J Biol Chem, vol.259, pp.5430-5439, 1984.

F. Marino, M. Cosentino, A. M. Fietta, M. Ferrari, S. Cattaneo et al., Interleukin-8 production induced by the endozepine triakontatetraneuropeptide in human neutrophils: role of calcium and pharmacological investigation of signal transduction pathways, Cell Signal, vol.15, pp.511-517, 2003.

M. Martineau, T. Galli, G. Baux, and J. P. Mothet, Confocal imaging and tracking of the exocytotic routes for D-serine-mediated gliotransmission, Glia, vol.56, pp.1271-1284, 2008.
URL : https://hal.archives-ouvertes.fr/hal-00332637

O. Masmoudi-kouki, P. Gandolfo, J. Leprince, D. Vaudry, G. Pelletier et al., PACAP stimulates biosynthesis and release of endozepines from rat astrocytes, Ann N Y Acad Sci, vol.1070, pp.411-416, 2006.
URL : https://hal.archives-ouvertes.fr/hal-01973027

O. Masmoudi, P. Gandolfo, J. Leprince, D. Vaudry, A. Fournier et al., Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates endozepine release from cultured rat astrocytes via a PKA-dependent mechanism, Faseb J, vol.17, pp.17-27, 2003.
URL : https://hal.archives-ouvertes.fr/hal-01973023

O. Masmoudi, P. Gandolfo, T. Tokay, J. Leprince, A. Ravni et al., Somatostatin down-regulates the expression and release of endozepines from cultured rat astrocytes via distinct receptor subtypes, J Neurochem, vol.94, pp.561-571, 2005.
URL : https://hal.archives-ouvertes.fr/hal-01973025

K. Matsuda, K. Wada, T. Miura, K. Maruyama, S. I. Shimakura et al., Effect of the diazepam-binding inhibitor-derived peptide, octadecaneuropeptide, on food intake in goldfish, Neuroscience, vol.150, pp.425-432, 2007.
URL : https://hal.archives-ouvertes.fr/hal-01973087

S. Matsumoto, T. Yoshiga, and N. Yokoyama, Characterization of acyl-CoA-binding protein (ACBP) in the pheromone gland of the silkworm, Bombyx mori, Insect Biochem Mol Biol, vol.31, pp.603-609, 2001.

M. P. Mattson, Pathways towards and away from Alzheimer's disease, Nature, vol.430, pp.631-639, 2004.

M. P. Mattson, B. Cheng, D. Davis, K. Bryant, I. Lieberburg et al., beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity, J Neurosci, vol.12, pp.376-389, 1992.

K. W. Mcdermott, D. S. Barry, and S. S. Mcmahon, Role of radial glia in cytogenesis, patterning and boundary formation in the developing spinal cord, J Anat, vol.207, pp.241-250, 2005.

M. W. Mcenery, A. M. Snowman, R. R. Trifiletti, and S. H. Snyder, Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier, Proc Natl Acad Sci, vol.89, pp.3170-3174, 1992.

E. Mcgowan, F. Pickford, and J. Kim, Abeta42 is essential for parenchymal and vascular amyloid deposition in mice, Neuron, vol.47, pp.191-199, 2005.

M. J. Mcnamara, T. Gomez-isla, and B. T. Hyman, Apolipoprotein E genotype and deposits of Abeta40 and Abeta42 in Alzheimer disease, Arch Neurol, vol.55, pp.1001-1004, 1998.

J. H. Medina, A. C. Paladini, and I. Izquierdo, Naturally occurring benzodiazepines and benzodiazepine-like molecules in brain, Behav Brain Res, vol.58, pp.1-8, 1993.

H. Mehmet, Caspases find a new place to hide, Nature, vol.403, pp.29-30, 2000.

A. K. Mehta and M. K. Ticku, Benzodiazepine and beta-carboline interactions with GABAA receptor-gated chloride channels in mammalian cultured spinal cord neurons, J Pharmacol Exp Ther, vol.249, pp.418-423, 1989.

H. Meziane, J. C. Dodart, C. Mathis, S. Little, J. Clemens et al., Memory-enhancing effects of secreted forms of the beta-amyloid precursor protein in normal and amnestic mice, Proc Natl Acad Sci U S A, vol.95, pp.12683-12688, 1998.

I. Migeotte, D. Communi, and M. Parmentier, Formyl peptide receptors: a promiscuous subfamily of G protein-coupled receptors controlling immune responses, Cytokine Growth Factor Rev, vol.17, pp.501-519, 2006.

I. Migeotte, E. Riboldi, and J. D. Franssen, Identification and characterization of an endogenous chemotactic ligand specific for FPRL2, J Exp Med, vol.201, pp.83-93, 2005.

M. C. Miller, R. Tavares, C. E. Johanson, V. Hovanesian, J. E. Donahue et al., Hippocampal RAGE immunoreactivity in early and advanced Alzheimer's disease, vol.1230, pp.273-280, 2008.

R. H. Miller and M. C. Raff, Fibrous and protoplasmic astrocytes are biochemically and developmentally distinct, J Neurosci, vol.4, pp.585-592, 1984.

E. D. Milligan and L. R. Watkins, Pathological and protective roles of glia in chronic pain, Nat Rev Neurosci, vol.10, pp.23-36, 2009.

I. Mocchetti, R. Einstein, and J. Brosius, Putative diazepam binding inhibitor peptide: cDNA clones from rat, Proc Natl Acad Sci U S A, vol.83, pp.7221-7225, 1986.

I. Mocchetti and M. R. Santi, Diazepam binding inhibitor peptide: cloning and gene expression, Neuropharmacology, vol.30, pp.1365-1371, 1991.

I. B. Mogensen, H. Schulenberg, H. O. Hansen, F. Spener, and J. Knudsen, A novel acylCoA-binding protein from bovine liver. Effect on fatty acid synthesis, Biochem J, vol.241, pp.189-192, 1987.

H. Mohler and T. Okada, Benzodiazepine receptor: demonstration in the central nervous system, Science, vol.198, pp.849-851, 1977.

H. Mohler, P. Polc, R. Cumin, L. Pieri, and R. Kettler, Nicotinamide is a brain constituent with benzodiazepine-like actions, Nature, vol.278, pp.563-565, 1979.

B. W. Moore, A soluble protein characteristic of the nervous system, Biochem Biophys Res Commun, vol.19, pp.739-744, 1965.

D. Morgan, D. M. Diamond, and P. E. Gottschall, A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease, Nature, vol.408, pp.982-985, 2000.

S. Morgello, R. R. Uson, E. J. Schwartz, and R. S. Haber, The human blood-brain barrier glucose transporter (GLUT1) is a glucose transporter of gray matter astrocytes, Glia, vol.14, pp.43-54, 1995.

T. Mori, N. Koyama, G. W. Arendash, Y. Horikoshi-sakuraba, J. Tan et al., Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer's disease, Glia, vol.58, pp.300-314, 2010.

J. P. Mothet, L. Pollegioni, G. Ouanounou, M. Martineau, P. Fossier et al., , 2005.

, Glutamate receptor activation triggers a calcium-dependent and SNARE protein-dependent release of the gliotransmitter D-serine, Proc Natl Acad Sci U S A, vol.102, pp.5606-5611

P. N. Moynagh, The interleukin-1 signalling pathway in astrocytes: a key contributor to inflammation in the brain, J Anat, vol.207, pp.265-269, 2005.

P. M. Murphy, T. Ozcelik, R. T. Kenney, H. L. Tiffany, D. Mcdermott et al., A structural homologue of the N-formyl peptide receptor. Characterization and chromosome mapping of a peptide chemoattractant receptor family, J Biol Chem, vol.267, pp.7637-7643, 1992.

A. Musa, H. Lehrach, and V. A. Russo, Distinct expression patterns of two zebrafish homologues of the human APP gene during embryonic development, Dev Genes Evol, vol.211, pp.563-567, 2001.

R. G. Nagele, M. R. D'andrea, H. Lee, V. Venkataraman, and H. Y. Wang, Astrocytes accumulate A beta 42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains, Brain Res, vol.971, pp.197-209, 2003.

R. G. Nagele, J. Wegiel, V. Venkataraman, H. Imaki, K. C. Wang et al., Contribution of glial cells to the development of amyloid plaques in Alzheimer's disease, Neurobiol Aging, vol.25, pp.663-674, 2004.

K. Nakamura, H. Funakoshi, K. Miyamoto, F. Tokunaga, and T. Nakamura, Molecular cloning and functional characterization of a human scavenger receptor with C-type lectin (SRCL), a novel member of a scavenger receptor family, Biochem Biophys Res Commun, vol.280, pp.1028-1035, 2001.

K. Nakamura, W. Ohya, H. Funakoshi, G. Sakaguchi, A. Kato et al., Possible role of scavenger receptor SRCL in the clearance of amyloid, 2006.

, Alzheimer's disease, J Neurosci Res, vol.84, pp.874-890

S. Nakamura, K. Arima, S. Haga, T. Aizawa, Y. Motoi et al., Fibroblast growth factor (FGF)-9 immunoreactivity in senile plaques, Brain Res, vol.814, pp.222-225, 1998.

M. Nedergaard, B. Ransom, and S. A. Goldman, New roles for astrocytes: redefining the functional architecture of the brain, Trends Neurosci, vol.26, pp.523-530, 2003.

J. Neuhaus, W. Risau, and H. Wolburg, Induction of blood-brain barrier characteristics in bovine brain endothelial cells by rat astroglial cells in transfilter coculture, Ann N Y Acad Sci, vol.633, pp.578-580, 1991.

E. A. Newman, Sodium-bicarbonate cotransport in retinal astrocytes and Muller cells of the rat, Glia, vol.26, pp.302-308, 1999.

E. A. Newman, Glial cell inhibition of neurons by release of ATP, J Neurosci, vol.23, pp.1659-1666, 2003.

L. F. Nicholson, R. L. Faull, H. J. Waldvogel, and M. Dragunow, The regional, cellular and subcellular localization of GABAA/benzodiazepine receptors in the substantia nigra of the rat, Neuroscience, vol.50, pp.355-370, 1992.

R. Niddam, A. Dubois, B. Scatton, S. Arbilla, and S. Z. Langer, Autoradiographic localization of [3H]zolpidem binding sites in the rat CNS: comparison with the distribution of [3H]flunitrazepam binding sites, J Neurochem, vol.49, pp.890-899, 1987.

I. Nitz, F. Doring, J. Schrezenmeir, and B. Burwinkel, Identification of new acyl-CoA binding protein transcripts in human and mouse, Int J Biochem Cell Biol, vol.37, pp.2395-2405, 2005.

R. A. Nixon, Autophagy, amyloidogenesis and Alzheimer disease, J Cell Sci, vol.120, pp.4081-4091, 2007.

M. Noble, D. Wren, and G. Wolswijk, The O-2A(adult) progenitor cell: a glial stem cell of the adult central nervous system, Semin Cell Biol, vol.3, pp.413-422, 1992.

S. Oikari, T. Ahtialansaari, and M. V. Heinonen, Downregulation of PPARs and SREBP by acyl-CoA-binding protein overexpression in transgenic rats, Pflugers Arch, vol.456, pp.369-377, 2008.

S. Oikari, T. Ahtialansaari, A. Huotari, K. Kiehne, U. R. Folsch et al., Effect of medium-and long-chain fatty acid diets on PPAR and SREBP-1 expression and glucose homeostasis in ACBP-overexpressing transgenic rats, Acta Physiol (Oxf), vol.194, pp.57-65, 2008.

M. Okada, R. Nakao, R. Hosoi, M. R. Zhang, T. Fukumura et al., In vivo monitoring of extracellular 13N-glutamine derived from blood-borne 13N-ammonia in rat striatum using microdialysis with radio-LC method, J Neurosci Methods, vol.184, pp.37-41, 2009.

B. O. Oke, C. A. Suarez-quian, J. Riond, P. Ferrara, and V. Papadopoulos, Cell surface localization of the peripheral-type benzodiazepine receptor (PBR) in adrenal cortex, Mol Cell Endocrinol, vol.87, pp.1-6, 1992.

H. Onoe, H. Tsukada, S. Nishiyama, S. Nakanishi, O. Inoue et al., A subclass of GABAA/benzodiazepine receptor exclusively localized in the limbic system, Neuroreport, vol.8, pp.117-122, 1996.

I. G. Onyango, J. B. Tuttle, J. P. Bennett, and . Jr, Altered intracellular signaling and reduced viability of Alzheimer's disease neuronal cybrids is reproduced by beta-amyloid peptide acting through receptor for advanced glycation end products (RAGE), Mol Cell Neurosci, vol.29, pp.333-343, 2005.

J. M. Orgogozo, S. Gilman, and J. F. Dartigues, Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization, Neurology, vol.61, pp.46-54, 2003.

N. Origlia, M. Righi, and S. Capsoni, Receptor for advanced glycation end productdependent activation of p38 mitogen-activated protein kinase contributes to amyloid-beta-mediated cortical synaptic dysfunction, J Neurosci, vol.28, pp.3521-3530, 2008.

M. A. Ostuni and J. J. Lacapère, , 2005.

, Med Sci, vol.21, pp.240-242

G. P. Owens, A. K. Sinha, J. M. Sikela, and W. E. Hahn, Sequence and expression of the murine diazepam binding inhibitor, Brain Res Mol Brain Res, vol.6, pp.101-108, 1989.

A. Panatier, D. T. Theodosis, J. P. Mothet, B. Touquet, L. Pollegioni et al., Glia-derived D-serine controls NMDA receptor activity and synaptic memory, Cell, vol.125, pp.775-784, 2006.
URL : https://hal.archives-ouvertes.fr/inserm-00078312

V. Papadopoulos, Peripheral benzodiazepine receptor: structure and function in health and disease, Ann Pharm Fr, vol.61, pp.30-50, 2003.

V. Papadopoulos, M. Baraldi, and T. R. Guilarte, Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function, Trends Pharmacol Sci, vol.27, pp.402-409, 2006.

V. Papadopoulos, A. Berkovich, and K. E. Krueger, The role of diazepam binding inhibitor and its processing products at mitochondrial benzodiazepine receptors: regulation of steroid biosynthesis, Neuropharmacology, vol.30, pp.1417-1423, 1991.

V. Papadopoulos, A. Berkovich, K. E. Krueger, E. Costa, and A. Guidotti, Diazepam binding inhibitor and its processing products stimulate mitochondrial steroid biosynthesis via an interaction with mitochondrial benzodiazepine receptors, Endocrinology, vol.129, pp.1481-1488, 1991.

V. Papadopoulos, A. G. Mukhin, E. Costa, and K. E. Krueger, The peripheral-type benzodiazepine receptor is functionally linked to Leydig cell steroidogenesis, J Biol Chem, vol.265, pp.3772-3779, 1990.

A. L. Parola and H. E. Laird, The bovine peripheral-type benzodiazepine receptor: a receptor with low affinity for benzodiazepines, Life Sci, vol.2, pp.757-764, 1991.

V. Parpura, B. J. Baker, M. Jeras, and R. Zorec, Regulated exocytosis in astrocytic signal integration, Neurochem Int, 2010.

V. Parpura, T. A. Basarsky, F. Liu, K. Jeftinija, S. Jeftinija et al., Glutamatemediated astrocyte-neuron signalling, Nature, vol.369, pp.744-747, 1994.

M. Parramon, M. J. Oset-gasque, M. P. Gonzalez, and F. A. Stephenson, Identification of GABAA receptor subunits expressed in bovine adrenal medulla, Neurosci Lett, vol.168, pp.243-246, 1994.

S. Parvathy, I. Hussain, E. H. Karran, A. J. Turner, and N. M. Hooper, Alzheimer's amyloid precursor protein alpha-secretase is inhibited by hydroxamic acid-based zinc metalloprotease 5pIpUHQFHV %LEOLRJUDSKLTXHV inhibitors: similarities to the angiotensin converting enzyme secretase, Biochemistry, vol.37, pp.1680-1685, 1998.

O. Pascual, K. B. Casper, and C. Kubera, Astrocytic purinergic signaling coordinates synaptic networks, Science, vol.310, pp.113-116, 2005.

C. Patte, P. Gandolfo, J. Leprince, J. L. Thoumas, M. Fontaine et al., GABA inhibits endozepine release from cultured rat astrocytes, Glia, vol.25, pp.404-411, 1999.
URL : https://hal.archives-ouvertes.fr/hal-01973857

C. Patte, H. Vaudry, L. Desrues, P. Gandolfo, I. Strijdveen et al., The endozepine ODN stimulates polyphosphoinositide metabolism in rat astrocytes, FEBS Lett, vol.362, pp.106-110, 1995.

M. Pekny and M. Nilsson, Astrocyte activation and reactive gliosis, Glia, vol.50, pp.427-434, 2005.

G. Perea, M. Navarrete, and A. Araque, Tripartite synapses: astrocytes process and control synaptic information, Trends Neurosci, vol.32, pp.421-431, 2009.

C. J. Pike, A. J. Walencewicz-wasserman, J. Kosmoski, D. H. Cribbs, C. G. Glabe et al., Structure-activity analyses of beta-amyloid peptides: contributions of the beta 25-35 region to aggregation and neurotoxicity, J Neurochem, vol.64, pp.253-265, 1995.

M. B. Podlisny, D. R. Tolan, and D. J. Selkoe, Homology of the amyloid beta protein precursor in monkey and human supports a primate model for beta amyloidosis in Alzheimer's disease, Am J Pathol, vol.138, pp.1423-1435, 1991.

R. Postina, A. Schroeder, and I. Dewachter, A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model, J Clin Invest, vol.113, pp.1456-1464, 2004.

J. E. Powell and D. Taylor, Anger, depression, and anxiety following heroin withdrawal, Int J Addict, vol.27, pp.25-35, 1992.

C. Prat, J. Bestebroer, C. J. De-haas, J. A. Van-strijp, and K. P. Van-kessel, A new staphylococcal anti-inflammatory protein that antagonizes the formyl peptide receptor-like 1, J Immunol, vol.177, pp.8017-8026, 2006.

D. B. Pritchett, H. Luddens, and P. H. Seeburg, ) Type I and type II GABAA-benzodiazepine receptors produced in transfected cells, Science, vol.245, pp.1389-1392, 1989.

G. Puia, S. Vicini, P. H. Seeburg, and E. Costa, Influence of recombinant gammaaminobutyric acid-A receptor subunit composition on the action of allosteric modulators of gamma-aminobutyric acid-gated Cl-currents, Mol Pharmacol, vol.39, pp.691-696, 1991.

W. Pusch, D. Jahner, A. N. Spiess, and R. Ivell, Rat endozepine-like peptide (ELP): cDNA cloning, genomic organization and tissue-specific expression, Gene, vol.235, pp.51-57, 1999.

L. Rago, A. Adojaan, and R. Masso, 3H]Ro 5-4864 binding sites in the nucleus of rat lymphocytes, Eur J Pharmacol, vol.187, pp.561-562, 1990.

P. Rakic, Developmental and evolutionary adaptations of cortical radial glia, Cereb Cortex, vol.13, pp.541-549, 2003.

S. Rakic and N. Zecevic, Emerging complexity of layer I in human cerebral cortex, Cereb Cortex, vol.13, pp.1072-1083, 2003.

L. O. Randall, Pharmacology of methaminodiazepoxide, Dis Nerv Syst, vol.21, issue.3, pp.7-10, 1960.

M. J. Rane, S. L. Carrithers, J. M. Arthur, J. B. Klein, and K. R. Mcleish, Formyl peptide receptors are coupled to multiple mitogen-activated protein kinase cascades by distinct signal transduction pathways: role in activation of reduced nicotinamide adenine dinucleotide oxidase, J Immunol, vol.159, pp.5070-5078, 1997.

B. R. Ransom, W. G. Carlini, and B. W. Connors, Brain extracellular space: developmental studies in rat optic nerve, Ann N Y Acad Sci, vol.481, pp.87-105, 1986.

B. R. Ransom, C. L. Yamate, and B. W. Connors, Activity-dependent shrinkage of extracellular space in rat optic nerve: a developmental study, J Neurosci, vol.5, pp.532-535, 1985.

K. V. Rao, K. S. Panickar, A. R. Jayakumar, and M. D. Norenberg, Astrocytes protect neurons from ammonia toxicity, Neurochem Res, vol.30, pp.1311-1318, 2005.

S. P. Raps, J. C. Lai, L. Hertz, and A. J. Cooper, Glutathione is present in high concentrations in cultured astrocytes but not in cultured neurons, Brain Res, vol.493, pp.398-401, 1989.

J. T. Rasmussen, N. J. Faergeman, K. Kristiansen, and J. Knudsen, Acyl-CoA-binding protein (ACBP) can mediate intermembrane acyl-CoA transport and donate acyl-CoA for beta-oxidation and glycerolipid synthesis, Biochem J, pp.165-170, 1994.

J. T. Rasmussen, J. Rosendal, and J. Knudsen, Interaction of acyl-CoA binding protein (ACBP) on processes for which acyl-CoA is a substrate, product or inhibitor, Biochem J, vol.292, pp.907-913, 1993.

K. E. Rhodes, L. D. Moon, and J. W. Fawcett, Inhibiting cell proliferation during formation of the glial scar: effects on axon regeneration in the CNS, Neuroscience, vol.120, pp.41-56, 2003.

L. Ricci, M. Valoti, G. Sgaragli, and M. Frosini, Neuroprotection afforded by diazepam against oxygen/glucose deprivation-induced injury in rat cortical brain slices, Eur J Pharmacol, vol.561, pp.80-84, 2007.

S. Ring, S. W. Weyer, and S. B. Kilian, The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice, J Neurosci, vol.27, pp.7817-7826, 2007.

J. Riond, M. G. Mattei, M. Kaghad, X. Dumont, J. C. Guillemot et al., Molecular cloning and chromosomal localization of a human peripheral-type benzodiazepine receptor, Eur J Biochem, vol.195, pp.305-311, 1991.

J. Riond, N. Vita, G. Le-fur, and P. Ferrara, Characterization of a peripheral-type benzodiazepine-binding site in the mitochondria of Chinese hamster ovary cells, FEBS Lett, vol.245, pp.238-244, 1989.

R. A. Rissman, A. L. De-blas, and D. M. Armstrong, GABA(A) receptors in aging and Alzheimer's disease, J Neurochem, vol.103, pp.1285-1292, 2007.

A. Rocchi, D. Orsucci, G. Tognoni, R. Ceravolo, and G. Siciliano, The role of vascular factors in late-onset sporadic Alzheimer's disease. Genetic and molecular aspects, Curr Alzheimer Res, vol.6, pp.224-237, 2009.

C. J. Rogers, R. E. Twyman, and R. L. Macdonald, Benzodiazepine and beta-carboline regulation of single GABAA receptor channels of mouse spinal neurones in culture, J Physiol, vol.475, pp.69-82, 1994.

H. A. Rohan-de-silva, A. Jen, C. Wickenden, L. S. Jen, S. L. Wilkinson et al., Cell-specific expression of beta-amyloid precursor protein isoform mRNAs and proteins in neurons and astrocytes, Mol Brain Res, vol.47, pp.147-156, 1997.

C. R. Rose and B. R. Ransom, Gap junctions equalize intracellular Na+ concentration in astrocytes, Glia, vol.20, pp.299-307, 1997.

T. M. Rose, E. R. Schultz, G. C. Sasaki, P. E. Kolattukudy, and M. Shoyab, Nucleotide sequence and genomic structure of duck acyl-CoA binding protein/diazepam-binding inhibitor: colocalization with S-acyl fatty acid synthase thioesterase, DNA Cell Biol, vol.13, pp.669-678, 1994.

T. M. Rose, E. R. Schultz, and G. J. Todaro, Molecular cloning of the gene for the yeast homolog (ACB) of diazepam binding inhibitor/endozepine/acyl-CoA-binding protein, Proc Natl Acad Sci, vol.89, pp.11287-11291, 1992.

D. R. Rosen, L. Martin-morris, L. Q. Luo, and K. White, A Drosophila gene encoding a protein resembling the human beta-amyloid protein precursor, Proc Natl Acad Sci U S A, vol.86, pp.2478-2482, 1989.

J. D. Rothstein, G. Mckhann, P. Guarneri, M. L. Barbaccia, A. Guidotti et al., Cerebrospinal fluid content of diazepam binding inhibitor in chronic hepatic encephalopathy, Ann Neurol, vol.26, pp.57-62, 1989.

A. Roy, Cerebrospinal fluid diazepam binding inhibitor in depressed patients and normal controls, Neuropharmacology, vol.30, pp.1441-1444, 1991.

A. Roy, D. Pickar, P. Gold, M. Barbaccia, A. Guidotti et al., , 1989.

, Diazepam-binding inhibitor and corticotropin-releasing hormone in cerebrospinal fluid, Acta Psychiatr Scand, vol.80, pp.287-291

J. I. Sagara, K. Miura, and S. Bannai, Maintenance of neuronal glutathione by glial cells, J Neurochem, vol.61, pp.1672-1676, 1993.

M. B. Sandberg, M. Bloksgaard, D. Duran-sandoval, C. Duval, B. Staels et al., The gene encoding acyl-CoA-binding protein is subject to metabolic regulation by both sterol regulatory element-binding protein and peroxisome proliferator-activated receptor alpha in hepatocytes, J Biol Chem, vol.280, pp.5258-5266, 2005.

R. Sandbrink, C. L. Masters, and K. Beyreuther, Beta A4-amyloid protein precursor mRNA isoforms without exon 15 are ubiquitously expressed in rat tissues including brain, but not in neurons, J Biol Chem, vol.269, pp.1510-1517, 1994.

D. Schenk, R. Barbour, and W. Dunn, Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse, Nature, vol.400, pp.173-177, 1999.

C. K. Schjerling, R. Hummel, J. K. Hansen, C. Borsting, J. M. Mikkelsen et al., Disruption of the gene encoding the acyl-CoA-binding protein (ACB1) perturbs acyl-CoA metabolism in Saccharomyces cerevisiae, J Biol Chem, vol.271, pp.22514-22521, 1996.

A. M. Schmidt, M. Vianna, and M. Gerlach, Isolation and characterization of two binding proteins for advanced glycosylation end products from bovine lung which are present on the endothelial cell surface, J Biol Chem, vol.267, pp.14987-14997, 1992.

H. Schoemaker, R. G. Boles, W. D. Horst, and H. I. Yamamura, Specific high-affinity binding sites for [3H]Ro 5-4864 in rat brain and kidney, J Pharmacol Exp Ther, vol.225, pp.61-69, 1983.

P. R. Schofield, M. G. Darlison, and N. Fujita, Sequence and functional expression of the GABA A receptor shows a ligand-gated receptor super-family, Nature, vol.328, pp.221-227, 1987.

A. Schousboe, Role of astrocytes in the maintenance and modulation of glutamatergic and GABAergic neurotransmission, Neurochem Res, vol.28, pp.347-352, 2003.

D. Schubert, T. Soucek, and B. Blouw, The induction of HIF-1 reduces astrocyte activation by amyloid beta peptide, Eur J Neurosci, vol.29, pp.1323-1334, 2009.

N. G. Seidah, R. Day, M. Marcinkiewicz, and M. Chretien, Precursor convertases: an evolutionary ancient, cell-specific, combinatorial mechanism yielding diverse bioactive peptides and proteins, Ann N Y Acad Sci, vol.839, pp.9-24, 1998.

D. J. Selkoe, Alzheimer's disease: genes, proteins, and therapy, Physiol Rev, vol.81, pp.741-766, 2001.

D. J. Selkoe, Alzheimer's disease is a synaptic failure, Science, vol.298, pp.789-791, 2002.

P. Seubert, C. Vigo-pelfrey, and F. Esch, Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids, Nature, vol.359, pp.325-327, 1992.

T. Sherrin, T. Blank, R. Saravana, M. Rayner, J. Spiess et al., Region specific gene expression profile in mouse brain after chronic corticotropin releasing factor receptor 1 activation: the novel role for diazepam binding inhibitor in contextual fear conditioning, Neuroscience, vol.162, pp.14-22, 2009.

E. H. Shin, H. Y. Lee, S. D. Kim, S. H. Jo, M. K. Kim et al., antagonizes formyl peptide receptor like 2-mediated signaling, Biochem Biophys Res Commun, vol.341, pp.1317-1322, 2006.

J. H. Shin, S. W. Kim, C. M. Lim, J. Y. Jeong, C. S. Piao et al., ) alphaB-crystallin suppresses oxidative stress-induced astrocyte apoptosis by inhibiting caspase-3 activation, Neurosci Res, vol.64, pp.355-361, 2009.

M. Shoji, T. E. Golde, and J. Ghiso, Production of the Alzheimer amyloid beta protein by normal proteolytic processing, Science, vol.258, pp.126-129, 1992.

W. Sieghart, Benzodiazepine receptor subtypes and their possible clinical significance, Psychopharmacol Ser, vol.7, pp.131-137, 1989.

W. Sieghart, Unraveling the function of GABA(A) receptor subtypes, Trends Pharmacol Sci, vol.21, pp.411-413, 2000.

W. Sieghart and H. Moehler, 3H]clonazepam, like [3H]flunitrazepam, is a photoaffinity label for the central type of benzodiazepine receptors, Eur J Pharmacol, vol.81, pp.171-173, 1982.

D. H. Sieglaff, K. A. Duncan, and M. R. Brown, Expression of genes encoding proteins involved in ecdysteroidogenesis in the female mosquito, Aedes aegypti. Insect Biochem Mol Biol, vol.35, pp.471-490, 2005.

H. Siiskonen, S. Oikari, and V. P. Korhonen, Diazepam binding inhibitor overexpression in mice causes hydrocephalus, decreases plasticity in excitatory synapses and impairs hippocampusdependent learning, Mol Cell Neurosci, vol.34, pp.199-208, 2007.

I. A. Silver and M. Erecinska, Energetic demands of the Na+/K+ ATPase in mammalian astrocytes, Glia, vol.21, pp.35-45, 1997.

R. L. Silverstein and M. Febbraio, CD36, a scavenger receptor involved in immunity, metabolism, angiogenesis, and behavior, Sci Signal, vol.2, p.3, 2009.

M. Slezak and F. W. Pfrieger, New roles for astrocytes: regulation of CNS synaptogenesis, Trends Neurosci, vol.26, pp.531-535, 2003.

E. Slobodyansky, L. Antkiewicz-michaluk, and B. Martin, Purification of a novel DBI processing product, DBI39-75, and characterization of its binding site in rat brain, Regul Pept, vol.50, pp.29-35, 1994.

E. Slobodyansky, A. Guidotti, C. Wambebe, A. Berkovich, and E. Costa, Isolation and characterization of a rat brain triakontatetraneuropeptide, a posttranslational product of diazepam binding inhibitor: specific action at the Ro 5-4864 recognition site, J Neurochem, vol.53, pp.1276-1284, 1989.

H. H. Slunt, G. Thinakaran, C. Von-koch, A. C. Lo, R. E. Tanzi et al., Expression of a ubiquitous, cross-reactive homologue of the mouse beta-amyloid precursor protein (APP), J Biol Chem, vol.269, pp.2637-2644, 1994.

M. J. Snyder and R. Feyereisen, A diazepam binding inhibitor (DBI) homolog from the tobacco hornworm, Manduca sexta, Mol Cell Endocrinol, vol.94, 1993.

M. V. Sofroniew, Molecular dissection of reactive astrogliosis and glial scar formation, Trends Neurosci, vol.32, pp.638-647, 2009.

M. V. Sofroniew and H. V. Vinters, Astrocytes: biology and pathology, Acta Neuropathol, vol.119, pp.7-35, 2010.

S. Spisani, M. C. Pareschi, and M. Buzzi, Effect of cyclic AMP level reduction on human neutrophil responses to formylated peptides, Cell Signal, vol.8, pp.269-277, 1996.

H. Stepien, A. Agro, J. Crossley, I. Padol, C. Richards et al., Immunomodulatory properties of diazepam-binding inhibitor: effect on human interleukin-6 secretion, lymphocyte proliferation and natural killer cell activity in vitro, Neuropeptides, vol.25, pp.207-211, 1993.

B. Stix and G. Reiser, Beta-amyloid peptide 25-35 regulates basal and hormone-stimulated Ca2+ levels in cultured rat astrocytes, Neurosci Lett, vol.243, pp.121-124, 1998.

M. H. Stridh, F. Correa, C. Nodin, S. G. Weber, F. Blomstrand et al., Enhanced glutathione efflux from astrocytes in culture by low extracellular Ca2+ and curcumin, Neurochem Res, vol.35, pp.1231-1238, 2010.

J. H. Su, A. J. Anderson, D. H. Cribbs, C. Tu, L. Tong et al., Fas and Fas ligand are associated with neuritic degeneration in the AD brain and participate in betaamyloid-induced neuronal death, Neurobiol Dis, vol.12, pp.182-193, 2003.

S. B. Su, W. Gong, J. L. Gao, W. Shen, P. M. Murphy et al., A seven-transmembrane, G protein-coupled receptor, FPRL1, mediates the chemotactic activity of serum amyloid A for human phagocytic cells, J Exp Med, vol.189, pp.395-402, 1999.

S. B. Su, W. H. Gong, J. L. Gao, W. P. Shen, M. C. Grimm et al., T20/DP178, an ectodomain peptide of human immunodeficiency virus type 1 gp41, is an activator of human phagocyte N-formyl peptide receptor, Blood, vol.93, pp.3885-3892, 1999.

S. K. Sudakov, O. F. Medvedeva, I. V. Rusakova, N. N. Terebilina, and S. R. Goldberg, Differences in genetic predisposition to high anxiety in two inbred rat strains: role of substance P, diazepam binding inhibitor fragment and neuropeptide Y, Psychopharmacology (Berl), vol.154, pp.327-335, 2001.

R. Sun, P. Iribarren, and N. Zhang, Identification of neutrophil granule protein cathepsin G as a novel chemotactic agonist for the G protein-coupled formyl peptide receptor, J Immunol, vol.173, pp.428-436, 2004.

N. Suzuki, T. T. Cheung, X. D. Cai, A. Odaka, L. Otvos et al., An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants, Science, vol.264, pp.1336-1340, 1994.

J. V. Swinnen, P. Alen, W. Heyns, and G. Verhoeven, , 1998.

/. Inhibitor and . Acyl, CoA-binding protein as a sterol regulatory element-binding protein-responsive gene, J Biol Chem, vol.273, 19938.

J. V. Swinnen, M. Esquenet, W. Heyns, W. Rombauts, and G. Verhoeven, Androgen regulation of the messenger RNA encoding diazepam-binding inhibitor/acyl-CoA-binding protein in the human prostatic adenocarcinoma cell line LNCaP, Mol Cell Endocrinol, vol.104, pp.153-162, 1994.

J. V. Swinnen, M. Esquenet, J. Rosseels, F. Claessens, W. Rombauts et al., A human gene encoding diazepam-binding inhibitor/acy1-CoA-binding protein: transcription and hormonal regulation in the androgen-sensitive human prostatic adenocarcinoma cell line LNCaP, DNA Cell Biol, vol.15, pp.197-208, 1996.

J. V. Swinnen, I. Vercaeren, M. Esquenet, W. Heyns, and G. Verhoeven, Androgen regulation of the messenger RNA encoding diazepam-binding inhibitor/acyl-CoA-binding protein in the rat, Mol Cell Endocrinol, vol.118, pp.65-70, 1996.

T. Takano, S. Fiore, J. F. Maddox, H. R. Brady, N. A. Petasis et al., Aspirintriggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors, J Exp Med, vol.185, pp.1693-1704, 1997.

K. Takuma, S. S. Yan, D. M. Stern, and K. Yamada, Mitochondrial dysfunction, endoplasmic reticulum stress, and apoptosis in Alzheimer's disease, J Pharmacol Sci, vol.97, pp.312-316, 2005.

D. Talwar and P. K. Sher, Benzodiazepine receptor development in murine glial cultures, Dev Neurosci, vol.9, pp.183-189, 1987.

E. Tamagno, M. Parola, M. Guglielmotto, G. Santoro, P. Bardini et al., Multiple signaling events in amyloid beta-induced, oxidative stress-dependent neuronal apoptosis, Free Radic Biol Med, vol.35, pp.45-58, 2003.

S. Tanaka, S. Shiojiri, Y. Takahashi, N. Kitaguchi, H. Ito et al., Tissue-specific expression of three types of beta-protein precursor mRNA: enhancement of protease inhibitor-harboring types in Alzheimer's disease brain, Biochem Biophys Res Commun, vol.165, pp.1406-1414, 1989.

P. T. Tarr and P. A. Edwards, ABCG1 and ABCG4 are coexpressed in neurons and astrocytes of the CNS and regulate cholesterol homeostasis through SREBP-2, J Lipid Res, vol.49, pp.169-182, 2008.

V. Taupin, J. Gogusev, B. Descamps-latscha, and F. Zavala, Modulation of tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6, interleukin-8, and granulocyte/macrophage colonystimulating factor expression in human monocytes by an endogenous anxiogenic benzodiazepine ligand, triakontatetraneuropeptide: evidence for a role of prostaglandins, Mol Pharmacol, vol.43, pp.64-69, 1993.

V. Taupin, A. Herbelin, B. Descamps-latscha, and F. Zavala, Endogenous anxiogenic peptide, ODN-diazepam-binding inhibitor, and benzodiazepines enhance the production of interleukin-1 and tumor necrosis factor by human monocytes, Lymphokine Cytokine Res, vol.10, pp.7-13, 1991.

R. Tavolaro, M. Canonaco, and M. F. Franzoni, A quantitative autoradiographic study of GABAA and benzodiazepine receptors in the brain of the frog, Rana esculenta, Brain Behav Evol, vol.42, pp.171-177, 1993.

S. S. Tenen and J. D. Hirsch, beta-Carboline-3-carboxylic acid ethyl ester antagonizes diazepam activity, Nature, vol.288, pp.609-610, 1980.

C. K. Thoeringer, E. B. Binder, and D. Salyakina, Association of a Met88Val diazepam binding inhibitor (DBI) gene polymorphism and anxiety disorders with panic attacks, J Psychiatr Res, vol.41, pp.579-584, 2007.

H. L. Tiffany, M. C. Lavigne, Y. H. Cui, J. M. Wang, T. L. Leto et al., Amyloid-beta induces chemotaxis and oxidant stress by acting at formylpeptide receptor 2, a G protein-coupled receptor expressed in phagocytes and brain, J Biol Chem, vol.276, pp.23645-23652, 2001.

G. J. Todaro, T. M. Rose, and M. Shoyab, Human DBI (endozepine): relationship to a homologous membrane associated protein (MA-DBI), Neuropharmacology, vol.30, pp.1373-1380, 1991.

S. Todd and S. L. Naylor, New chromosomal mapping assignments for argininosuccinate synthetase pseudogene 1, interferon-beta 3 gene, and the diazepam binding inhibitor gene, Somat Cell Mol Genet, vol.18, pp.381-385, 1992.

T. Tokay, R. Hachem, and O. Masmoudi-kouki, Beta-amyloid peptide stimulates endozepine release in cultured rat astrocytes through activation of N-formyl peptide receptors, 2008.
URL : https://hal.archives-ouvertes.fr/hal-01974262

, Glia, vol.56, pp.1380-1389

T. Tokay, O. Masmoudi, P. Gandolfo, J. Leprince, G. Pelletier et al., Beta-amyloid peptides stimulate endozepine biosynthesis in cultured rat astrocytes, J Neurochem, vol.94, pp.607-616, 2005.
URL : https://hal.archives-ouvertes.fr/hal-01974260

Y. Tong, E. Rheaume, J. Simard, and G. Pelletier, Localization of peripheral benzodiazepine binding sites and diazepam-binding inhibitor (DBI) mRNA in mammary glands and dimethylbenz(a)antracene (DMBA)-induced mammary tumors in the rat, Regul Pept, vol.33, pp.263-273, 1991.

Y. Tong, D. Toranzo, and G. Pelletier, Localization of diazepam-binding inhibitor (DBI) mRNA in the rat brain by high resolution in situ hybridization, Neuropeptides, vol.20, pp.33-40, 1991.

M. C. Tonon, S. Adjeroud, M. Lamacz, E. Louiset, J. M. Danger et al., Central-type benzodiazepines and the octadecaneuropeptide modulate the effects of GABA on the release of alpha-melanocyte-stimulating hormone from frog neurointermediate lobe in vitro, Neuroscience, vol.31, pp.485-493, 1989.

M. C. Tonon, L. Desy, P. Nicolas, H. Vaudry, and G. Pelletier, Immunocytochemical localization of the endogenous benzodiazepine ligand octadecaneuropeptide (ODN) in the rat brain, Neuropeptides, vol.15, pp.17-24, 1990.

M. C. Tonon, J. Leprince, P. Gandolfo, V. Compère, G. Pelletier et al., Handbook of Biologically Active Peptides, 2006.

D. Toranzo, Y. Tong, M. C. Tonon, H. Vaudry, and G. Pelletier, Localization of diazepambinding inhibitor and peripheral type benzodiazepine binding sites in the rat ovary, Anat Embryol (Berl), vol.190, pp.383-388, 1994.

I. Torgner and E. Kvamme, Synthesis of transmitter glutamate and the glial-neuron interrelationship, Mol Chem Neuropathol, vol.12, pp.11-17, 1990.

V. C. Toro, R. Tehranian, M. Zetterstrom, G. Eriksson, U. Langel et al., Increased gene expression of interleukin-1alpha and interleukin-6 in rat primary glial cells induced by beta-amyloid fragment, J Mol Neurosci, vol.17, pp.341-350, 2001.

V. Tretter, N. Ehya, K. Fuchs, and W. Sieghart, Stoichiometry and assembly of a recombinant GABAA receptor subtype, J Neurosci, vol.17, pp.2728-2737, 1997.

K. Ueda, S. Shinohara, T. Yagami, K. Asakura, and K. Kawasaki, Amyloid beta protein potentiates Ca2+ influx through L-type voltage-sensitive Ca2+ channels: a possible involvement of free radicals, J Neurochem, vol.68, pp.265-271, 1997.

E. M. Ullian, S. K. Sapperstein, K. S. Christopherson, and B. A. Barres, Control of synapse number by glia, Science, vol.291, pp.657-661, 2001.

C. G. Vanoye, A. F. Castro, T. Pourcher, L. Reuss, and G. A. Altenberg, Phosphorylation of P-glycoprotein by PKA and PKC modulates swelling-activated Cl-currents, Am J Physiol, vol.276, pp.370-378, 1999.

H. Vaudry, M. C. Tonon, C. Delarue, R. Vaillant, and J. Kraicer, Biological and radioimmunological evidence for melanocyte stimulating hormones (MSH) of extrapituitary origin in the rat brain, Neuroendocrinology, vol.27, pp.9-24, 1978.

Z. Vidnyanszky, T. J. Gorcs, and J. Hamori, Diazepam binding inhibitor fragment 33-50 (octadecaneuropeptide) immunoreactivity in the cerebellar cortex is restricted to glial cells, Glia, vol.10, pp.132-141, 1994.

T. Vitalis, C. Fouquet, C. Alvarez, I. Seif, D. Price et al., Developmental expression of monoamine oxidases A and B in the central and peripheral nervous systems of the mouse, J Comp Neurol, vol.442, pp.331-347, 2002.

C. Vock, F. Doring, and I. Nitz, Transcriptional regulation of HMG-CoA synthase and HMGCoA reductase genes by human ACBP, Cell Physiol Biochem, vol.22, pp.515-524, 2008.

A. Volterra and J. Meldolesi, Astrocytes, from brain glue to communication elements: the revolution continues, Nat Rev Neurosci, vol.6, pp.626-640, 2005.

H. J. Waldvogel, Y. Kubota, J. Fritschy, H. Mohler, and R. L. Faull, Regional and cellular localisation of GABA(A) receptor subunits in the human basal ganglia: An autoradiographic and immunohistochemical study, J Comp Neurol, vol.415, pp.313-340, 1999.

A. Walther, K. Riehemann, and V. Gerke, A novel ligand of the formyl peptide receptor: annexin I regulates neutrophil extravasation by interacting with the FPR, Mol Cell, vol.5, pp.831-840, 2000.

J. L. Wang, J. X. Wang, and X. F. Zhao, Molecular cloning and expression profiles of the acyl-CoA-binding protein gene from the cotton bollworm Helicoverpa armigera, Arch Insect Biochem Physiol, vol.68, pp.79-88, 2008.

W. Wasco, K. Bupp, M. Magendantz, J. F. Gusella, R. E. Tanzi et al., Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer diseaseassociated amyloid beta protein precursor, Proc Natl Acad Sci, vol.89, pp.10758-10762, 1992.

J. A. Watt, C. J. Pike, A. J. Walencewicz-wasserman, and C. W. Cotman, Ultrastructural analysis of beta-amyloid-induced apoptosis in cultured hippocampal neurons, Brain Res, vol.661, pp.147-156, 1994.

N. R. Webb, T. M. Rose, N. Malik, H. Marquardt, M. Shoyab et al., Bovine and human cDNA sequences encoding a putative benzodiazepine receptor ligand, DNA, vol.6, pp.71-79, 1987.

W. Wei, D. D. Norton, X. Wang, and J. W. Kusiak, Abeta 17-42 in Alzheimer's disease activates JNK and caspase-8 leading to neuronal apoptosis, Brain, vol.125, pp.2036-2043, 2002.

R. Wender, A. M. Brown, R. Fern, R. A. Swanson, K. Farrell et al., Astrocytic glycogen influences axon function and survival during glucose deprivation in central white matter, J Neurosci, vol.20, pp.6804-6810, 2000.

K. Wenzel-seifert and R. Seifert, Cyclosporin H is a potent and selective formyl peptide receptor antagonist, 1993.

B. Phenylalanyl-l-leucyl-l-phenylalanine, C. , D. , and E. Immunol, , vol.150, pp.4591-4599

M. D. Wewers, IL-1beta: an endosomal exit, Proc Natl Acad Sci U S A, vol.101, pp.10241-10242, 2004.

E. R. Whittemore, D. T. Loo, J. A. Watt, and C. W. Cotman, A detailed analysis of hydrogen peroxide-induced cell death in primary neuronal culture, Neuroscience, vol.67, pp.921-932, 1995.

J. Wildmann, Increase of natural benzodiazepines in wheat and potato during germination, Biochem Biophys Res Commun, vol.157, pp.1436-1443, 1988.

J. Wildmann, H. Mohler, W. Vetter, U. Ranalder, K. Schmidt et al., Diazepam and N-desmethyldiazepam are found in rat brain and adrenal and may be of plant origin, J Neural Transm, vol.70, pp.383-398, 1987.

J. Wildmann, J. Niemann, and H. Matthaei, Endogenous benzodiazepine receptor agonist in human and mammalian plasma, J Neural Transm, vol.66, pp.151-160, 1986.

U. Wilhelmsson, E. A. Bushong, D. L. Price, B. L. Smarr, V. Phung et al., Redefining the concept of reactive astrocytes as cells that remain within their unique domains upon reaction to injury, Proc Natl Acad Sci U S A, vol.103, pp.17513-17518, 2006.

M. Willis, W. A. Kaufmann, and G. Wietzorrek, L-type calcium channel CaV 1.2 in transgenic mice overexpressing human AbetaPP751 with the London (V717I) and Swedish (K670M/N671L) mutations, J Alzheimers Dis, vol.20, pp.1167-1180, 2010.

J. P. Wisor, D. M. Edgar, J. Yesavage, H. S. Ryan, C. M. Mccormick et al., Sleep and circadian abnormalities in a transgenic mouse model of Alzheimer's disease: a role for cholinergic transmission, Neuroscience, vol.131, pp.375-385, 2005.

M. S. Wolfe, Inhibition and modulation of gamma-secretase for Alzheimer's disease, Neurotherapeutics, vol.5, pp.391-398, 2008.

J. R. Wolff, K. Stuke, M. Missler, H. Tytko, P. Schwarz et al., Autocellular coupling by gap junctions in cultured astrocytes: a new view on cellular autoregulation during process formation, Glia, vol.24, pp.121-140, 1998.

M. J. Woods, D. M. Zisterer, and D. C. Williams, Two cellular and subcellular locations for the peripheral-type benzodiazepine receptor in rat liver, Biochem Pharmacol, vol.51, pp.1283-1292, 1996.

C. Wu, T. Wong, X. Wu, E. Sheppy, and L. Zhang, Adenosine as an endogenous regulating factor of hippocampal sharp waves, Hippocampus, vol.19, pp.205-220, 2009.

K. L. Wu, C. Hsu, J. Y. Chan, W. Xia, J. Zhang et al., Impairment of the mitochondrial respiratory enzyme activity triggers sequential activation of apoptosis-inducing factor-dependent and caspasedependent signaling pathways to induce apoptosis after spinal cord injury, Proc Natl Acad Sci U S A, vol.101, pp.8208-8213, 1997.

H. Yamagishi and M. Kawaguchi, Characterization of central-and peripheral-type benzodiazepine receptors in rat salivary glands, Biochem Pharmacol, vol.55, pp.209-214, 1998.

S. F. Yan, R. Ramasamy, and A. M. Schmidt, Soluble RAGE: therapy and biomarker in unraveling the RAGE axis in chronic disease and aging, Biochem Pharmacol, vol.79, pp.1379-1386, 2010.

K. Yanagibashi, Y. Ohno, M. Kawamura, and P. F. Hall, The regulation of intracellular transport of cholesterol in bovine adrenal cells: purification of a novel protein, Endocrinology, vol.123, pp.2075-2082, 1988.

H. Yanase, H. Shimizu, T. Kanda, H. Fujii, and T. Iwanaga, Cellular localization of the diazepam binding inhibitor (DBI) in the gastrointestinal tract of mice and its coexistence with the fatty acid binding protein (FABP), Arch Histol Cytol, vol.64, pp.449-460, 2001.

H. Yanase, H. Shimizu, K. Yamada, and T. Iwanaga, Cellular localization of the diazepam binding inhibitor in glial cells with special reference to its coexistence with brain-type fatty acid binding protein, Arch Histol Cytol, vol.65, pp.27-36, 2002.

D. Yang, Q. Chen, Y. Le, J. M. Wang, and J. J. Oppenheim, Differential regulation of formyl peptide receptor-like 1 expression during the differentiation of monocytes to dendritic cells and macrophages, J Immunol, vol.166, pp.4092-4098, 2001.

F. Yang, X. Sun, W. Beech, B. Teter, S. Wu et al., Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease, Am J Pathol, vol.152, pp.379-389, 1998.

Y. Yang, P. H. Pritchard, J. Bhuiyan, D. W. Seccombe, and M. H. Moghadasian, Overexpression of acyl-coA binding protein and its effects on the flux of free fatty acids in McA-RH 7777 cells, Lipids, vol.36, pp.595-600, 2001.

H. Yoshida, Y. Tsunoda, and C. Owyang, Diazepam-binding inhibitor33-50 elicits Ca2+ oscillation and CCK secretion in STC-1 cells via L-type Ca2+ channels, Am J Physiol, vol.276, pp.694-702, 1999.

J. K. Young, Immunoreactivity for diazepam binding inhibitor in Gomori-positive astrocytes, Regul Pept, vol.50, pp.159-165, 1994.

Z. Zhang, G. Chen, W. Zhou, A. Song, T. Xu et al., Regulated ATP release from astrocytes through lysosome exocytosis, Nat Cell Biol, vol.9, pp.945-953, 2007.

G. Zhao, G. Mao, J. Tan, Y. Dong, M. Z. Cui et al., Identification of a new presenilin-dependent zeta-cleavage site within the transmembrane domain of amyloid precursor protein, J Biol Chem, vol.279, pp.50647-50650, 2004.

J. Zhao, Y. Fu, and M. Yasvoina, Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis, J Neurosci, vol.27, pp.3639-3649, 2007.