Nickel‐Catalyzed Electrochemical Synthesis of (Hetero)Aryl Trifluoromethyl Selenides
Résumé
A convenient and efficient approach for the construction of aryl trifluoromethyl selenoethers from aryl iodides under mild conditions is reported. Electrochemical activation of stable and inexpensive NiBr2bipy (bipy – bipyridine) complex allows to avoid tedious Ni(COD)2 (COD – cyclooctadiene) catalyst. [NMe4][SeCF3] is employed as shelf-stable source of SeCF3 fragment and reaction is shown to tolerate wide range of substrates, including modification of drug-like molecules. Cyclic voltammetry studies allow insight into the reaction mechanism.