Fatal Invasive Trichosporonosis Caused by Trichosporon inkin after Allogeneic Stem Cell Transplant for very Severe Idiopathic Aplastic Anemia

Daphné Krzisch (1) , Vincent Camus (1) , Marion David (1) , Gilles Gargala (2, 3) , Stéphane Lepretre (1)

1 CLCC Henri Becquerel - Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen
2 ESCAPE - Epidémiosurveillance de protozooses à transmission alimentaire et vectorielle
3 Hôpital Charles Nicolle [Rouen]

Invasive Trichosporon inkin fungal infections are rare and unusual, occurring nearly exclusively in immunocompromised patients experiencing prolonged neutropenia during treatment of malignant hemopathies or other immunodeficiency conditions. We report a case of a 27-year-old patient with severe aplastic anemia who developed Trichosporon inkin sepsis with skin lesions during aplasia after myeloablative allogeneic stem cell transplant. He was treated with liposomal amphotericin B but died from multiple organ failure. We then discuss the epidemiological, clinical and therapeutic features of these serious fungal infections compared to the published data.

Mots clés: Trichosporon inkin; Aplastic anemia; Invasive fungal infection; Trichosporonosis; Hemopathy; Immunodeficiency; Antifungal therapy basidiomycetes

Domaines: Maladies infectieuses; Hématologie

Daphné Krzisch, Vincent Camus, Marion David, Gilles Gargala, Stéphane Lepretre. Fatal Invasive Trichosporonosis Caused by Trichosporon inkin after Allogeneic Stem Cell Transplant for very Severe Idiopathic Aplastic Anemia. Journal of Bacteriology & Parasitology, 2019, 10 (5), ⟨10.35248/2155-9597.19.10.364⟩. ⟨hal-03751954⟩