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Biocatalyst and continuous microfluidic reactor for an intensified production of n-butyl levulinate: kinetic model assessment

Abstract : The use of enzymes to catalyze chemical reactions has increased these recent years. Several models have been developed to express the kinetics over these biocatalysts. The most well-known of them, Michaelis-Menten, is used when only one substrate adsorbs on the enzyme. In the case of the esterification reaction, i.e., bimolecular system, a more complex kinetic model such as the Ping-Pong Bi-Bi should be applied. The use of such advanced models is essential for reactor scaleup and to optimize production. However, these models usually do not consider the reaction temperature. To fill this gap, a Ping-Pong Bi-Bi model was developed to produce butyl levulinate from the esterification of levulinic acid over an immobilized enzyme, Novozym®435. Microfluidic technology was used to ensure ideal mixing conditions. The Ping-Pong model, considering inhibition mechanisms, fits the experimental concentrations. ePC-SAFT equation of state was used to estimate the equilibrium constants.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-03748632
Contributor : Sébastien Leveneur Connect in order to contact the contributor
Submitted on : Tuesday, August 9, 2022 - 6:19:42 PM
Last modification on : Tuesday, September 27, 2022 - 4:11:24 AM
Long-term archiving on: : Thursday, November 10, 2022 - 6:55:55 PM

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Alexandre Cordier, Marcel Klinksiek, Christoph Held, Julien Legros, Sébastien Leveneur. Biocatalyst and continuous microfluidic reactor for an intensified production of n-butyl levulinate: kinetic model assessment. Chemical Engineering Journal, In press, ⟨10.1016/j.cej.2022.138541⟩. ⟨hal-03748632⟩

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