Aerobic and Biomimetic Activation of C-H Bonds of Phenols Catalysed by Copper-Amine Complexes

Mebrouka Dekhici (1) , Didier Villemin (2) , Nawel Cheikh (1, 3) , Nathalie Bar (2)

1 Université Tahri Mohamed Bechar [Bechar]
2 LCMT - Laboratoire de chimie moléculaire et thioorganique
3 Université de Tlemcen

Various copper complexes were prepared (CuCl(phen), CuCl(bipy), CuCl(neocu), CuCl(BPA), [CuCl(OH)(TMEDA)]2) and tested in aerobic room temperature oxidation of p-cresol. The complexe [CuCl(OH)(TMEDA)]2 was found to be the more efficient and was used in o,o and p,p coupling of various phenols and in the formation of quinones under aerobic conditions. The dimerization of substituted naphthols was also investigated. This C-H activation with formation of one CC bond and one harmless molecule of water with air as oxidant at room temperature represents a biomimetic model of enzyme Laccase.

Mots clés: green chemistry; aerobic oxidation; C-H activation; Cu complexe; phenols

Domaines: Chimie organique

Mebrouka Dekhici, Didier Villemin, Nawel Cheikh, Nathalie Bar. Aerobic and Biomimetic Activation of C-H Bonds of Phenols Catalysed by Copper-Amine Complexes. 25th International Electronic Conference on Synthetic Organic Chemistry, Nov 2021, Online, France. ⟨10.3390/ecsoc-25-11710⟩. ⟨hal-03670189⟩