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Identification and Biological Activities of Long-Chain Peptaibols Produced by a Marine-Derived Strain of Trichoderma longibrachiatum

Abstract : Six long-chain peptaibols, 1 - 6, were identified from agar cultures of a marine-derived Trichoderma longibrachiatum Rifai strain (MMS151) isolated from blue mussels. The structure elucidation was carried out using electrospray ionization ion trap mass spectrometry (ESI-IT-MS) and GC/EI-MS. The long-chain peptaibols exhibited the general building scheme Ac-Aib-Ala-Aib-Ala-Aib-XXX-Gln-Aib-Vxx-Aib-Gly-XXX-Aib-Pro-Vxx-Aib-XXX-Gln-Gln-Pheol and were similar or identical to recurrent 20-residue peptaibols produced by Trichoderma spp. Three new sequences were identified and were called longibrachins A-0, A-II-a, and A-IV-b. The isolated peptaibols were assayed for cytotoxic, antibacterial, and antifungal activities, and acute toxicity on Dipteran larvae.
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Submitted on : Thursday, March 3, 2022 - 1:01:26 PM
Last modification on : Wednesday, April 27, 2022 - 4:03:37 AM

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Mustapha Mohamed-Benkada, Yves François Pouchus, Philippe Vérité, Fabrice Pagniez, Nathalie Caroff, et al.. Identification and Biological Activities of Long-Chain Peptaibols Produced by a Marine-Derived Strain of Trichoderma longibrachiatum. Chemistry and Biodiversity, Wiley, 2016, 13 (5), pp.521-530. ⟨10.1002/cbdv.201500159⟩. ⟨hal-03595789⟩

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