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Journal articles

Convergent access to mono-fluoroalkene-based peptidomimetics

Abstract : Expeditive racemic synthesis of monofluoroalkene peptide isosteres from aldehydes and substituted aromatic sulfones is reported. The olefination reaction is highly Z -selective from substituted aldehydes to afford transoid peptide mimic precursors.
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Submitted on : Monday, February 14, 2022 - 5:26:12 PM
Last modification on : Saturday, June 25, 2022 - 9:57:34 AM



Florent Larnaud, Charlène Calata, Anaïs Prunier, Clothilde Le Guen, Rémi Legay, et al.. Convergent access to mono-fluoroalkene-based peptidomimetics. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2022, 20 (6), pp.1205-1218. ⟨10.1039/d1ob02441h⟩. ⟨hal-03573564⟩



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