Convergent access to mono-fluoroalkene-based peptidomimetics

Florent Larnaud (1) , Charlène Calata (1) , Anaïs Prunier (1) , Clothilde Le Guen (1) , Rémi Legay (1) , Emmanuel Pfund (1) , Thierry Lequeux (1)

1 LCMT - Laboratoire de chimie moléculaire et thioorganique

Expeditive racemic synthesis of monofluoroalkene peptide isosteres from aldehydes and substituted aromatic sulfones is reported. The olefination reaction is highly Z -selective from substituted aldehydes to afford transoid peptide mimic precursors.

Domaines: Chimie

Florent Larnaud, Charlène Calata, Anaïs Prunier, Clothilde Le Guen, Rémi Legay, et al.. Convergent access to mono-fluoroalkene-based peptidomimetics. Organic & Biomolecular Chemistry, 2022, 20 (6), pp.1205-1218. ⟨10.1039/d1ob02441h⟩. ⟨hal-03573564⟩