Paroxysmal nocturnal hemoglobinuria and vascular liver disease: Eculizumab therapy decreases mortality and thrombotic complications

Aurélie Plessier (1) , Marina Esposito‐farèse (2, 3) , Anna Baiges (4) , Akash Shukla (5) , Juan Carlos Garcia Pagan (6) , Emmanuelle de Raucourt (1) , Isabelle Ollivier‐hourmand (7) , Jean‐paul Cervoni (8) , Victor de Ledinghen (9) , Zoubida Tazi (10) , Jean‐baptiste Nousbaum (11) , René Bun (2, 3) , Christophe Bureau (12) , Christine Silvain (13) , Olivier Tournilhac (14) , Mathieu Gerfaud‐valentin (15) , François Durand (1) , Odile Goria (16, 17, 18, 19) , Luis Tellez (20, 21) , Agustin Albillos (22, 23) , Stefania Gioia (24) , Oliviero Riggio (24) , Andrea de Gottardi (25) , Audrey Payance (1) , Pierre‐emmanuel Rautou (1) , Louis Terriou (26) , Aude Charbonnier (27) , Laure Elkrief (28) , Regis Peffault Tour (29) , Dominique‐charles Valla (1) , Nathalie Gault (3, 1) , Flore Sicre Fontbrune (29)

1 Hôpital Beaujon [AP-HP]
2 AP-HP - Hôpital Bichat - Claude Bernard [Paris]
3 CIC 1425 - Centre d'investigation Clinique [CHU Bichat] - Épidémiologie clinique
4 Barcelona Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Clínic, IDIBAPS, University of Barcelona, Health Care Provider of the ERN-Liver, Centro de Investigación Biomédica Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Spain.
5 Department of Gastroenterology, Seth GS Medical College & KEM Hospital, Mumbai, India.
6 Barcelona Hepatic Hemodynamic Laboratory, Liver Unit, Hospital Clínic, IDIBAPS, University of Barcelona, Health Care Provider of the ERN-Liver, Centro de Investigación Biomédica Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Spain.
7 Hôpital Côte de Nacre [CHU Caen]
8 Service de Chirurgie Digestive [CHRU Besançon]
9 CHU Bordeaux [Bordeaux]
10 Internal Medicine, Mohammed V University Ibn Sina hospital, Rabat, Morocco.
11 CHU Brest - Service hépato-gastro-entérologie - CHU Brest - Service hépato-gastro-entérologie (CHU de Brest)
12 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
13 CHU Poitiers - Centre hospitalier universitaire de Poitiers
14 CHU Clermont-Ferrand
15 CHU Lyon Croix-Rousse, Hospices civils de Lyon
16 ADEN - Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau
17 IRIB - Institute for Research and Innovation in Biomedicine
18 UNIROUEN UFR Santé - UNIROUEN - UFR Santé
19 Service d'Hépato-Gastroentérologie [CHU Rouen]
20 Department of Gastroenterology and Hepatology, Hospital Ramón y Cajal Madrid, IRYCIS, Madrid, Spain.
21 Universidad de Alcalá, Madrid, Spain.
22 Department of Gastroenterology and Hepatology, Hospital Ramón y Cajal Madrid, IRYCIS, Madrid, Spain.
23 Universidad de Alcalá, Madrid, Spain.
24 Department of Translational and Precision Medicine, Sapienza University, Rome, Italy.
25 Inselspital, Bern, and Servizio di Gastroenterologia e Epatologia, Ente Ospedaliero Cantonale and Faculty of Biomedical Sciences, Università della Svizzera italiana, Lugano, Switzerland.
26 CHU Lille
27 CRLCC Centre Paoli - Calmettes [Marseille]
28 CHU Trousseau [Tours]
29 AP-HP - Hopital Saint-Louis [AP-HP]

Domains: Tissues and Organs [q-bio.TO]

Aurélie Plessier, Marina Esposito‐farèse, Anna Baiges, Akash Shukla, Juan Carlos Garcia Pagan, et al.. Paroxysmal nocturnal hemoglobinuria and vascular liver disease: Eculizumab therapy decreases mortality and thrombotic complications. American Journal of Hematology, 2022, ⟨10.1002/ajh.26474⟩. ⟨hal-03560134⟩