Feeding disorders in children with oesophageal atresia: a cross-sectional study

Aurélie Pham (1) , Emmanuelle Ecochard-Dugelay (2) , Arnaud Bonnard (2) , Enora Le Roux (2) , Thomas Gelas (3) , Véronique Rousseau (4) , Nadège Thomassin (5) , Isabelle Cabon-Boudard (6) , Audrey Nicolas (7) , Audrey Guinot (8) , Julie Rebeuh (9) , Aurélie Le Mandat (10) , Djamal-Dine Djeddi (11) , Virginie Fouquet (12) , Aurélie Boucharny (13) , Sabine Irtan (1) , Julie Lemale (1) , Aurélie Comte (14) , Laure Bridoux-Henno (15) , Claire Dupont-Lucas (16, 17, 18) , Georges Dimitrov (19) , Anne Turquet (20) , Corinne Borderon (21) , Cécile Pelatan (22) , Emilie Chaillou Legault (23) , Camille Jung (24) , Stéphanie Willot (25) , Louise Montalva (26) , Delphine Mitanchez (25) , Frederic Gottrand (7) , Marc Bellaiche (2)

1 CHU Trousseau [APHP]
2 AP-HP Hôpital universitaire Robert-Debré [Paris]
3 Hôpital Femme-Mère-EnfantHôpital Femme-Mère-Enfant, Service de Chirurgie Pédiatrique, CHU Lyon, Lyon, France.
4 CHU Necker - Enfants Malades [AP-HP]
5 CHU - Centre Hospitalier Universitaire [Grenoble]
6 TIMONE - Hôpital de la Timone [CHU - APHM]
7 CHU Lille
8 CHU Nantes - Centre hospitalier universitaire de Nantes
9 CHU Strasbourg
10 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
11 CHU Amiens-Picardie
12 AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre)
13 CHU Dijon - Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand
14 Service de chirurgie pédiatrique [CHU Besançon]
15 CHU Pontchaillou [Rennes]
16 CHU Caen
17 ADEN - Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau
18 IRIB - Institute for Research and Innovation in Biomedicine
19 CHRO - Centre Hospitalier Régional d'Orléans
20 CHU La Réunion - Centre Hospitalier Universitaire de La Réunion
21 CHU Clermont-Ferrand
22 Service de Pédiatrie [CH Le Mans]
23 CHU Angers - Centre Hospitalier Universitaire d'Angers
24 CHIC - Centre Hospitalier Intercommunal de Créteil
25 CHRU Tours - Centre Hospitalier Régional Universitaire de Tours
26 Centre de Référence des Maladies Endocriniennes Rares de la Croissance [APHP Robert Debré]

Introduction With advances in surgical and neonatal care, the survival of patients with oesophageal atresia (OA) has improved over time. Whereas a number of OA-related conditions (delayed primary anastomosis, anastomotic stricture and oesophageal dysmotility) may have an impact on feeding development and although children with OA experience several oral aversive events, paediatric feeding disorders (PFD) remain poorly described in this population. The primary aim of our study was to describe PFD in children born with OA, using a standardised scale. The secondary aim was to determine conditions associated with PFD. Methods The Feeding Disorders in Children with Oesophageal Atresia Study is a national cohort study based on the OA registry from the French National Network. Parents of children born with OA between 2013 and 2016 in one of the 22 participating centres were asked to complete the French version of the Montreal Children’s Hospital Feeding Scale. Results Of the 248 eligible children, 145 children, with a median age of 2.3 years (Q1–Q3 1.8–2.9, min–max 1.1–4.0 years), were included. Sixty-one children (42%) developed PFD; 13% were tube-fed (n=19). Almost 40% of children with PFD failed to thrive (n=23). The presence of chronic respiratory symptoms was associated with the development of PFD. Ten children with PFD (16%) had no other condition or OA-related complication. Conclusion PFD are common in children with OA, and there is no typical profile of patients at risk of PFD. Therefore, all children with OA require a systematic screening for PFD that could improve the care and outcomes of patients, especially in terms of growth.

Domains: Life Sciences [q-bio]; Human health and pathology; Tissues and Organs [q-bio.TO]

Aurélie Pham, Emmanuelle Ecochard-Dugelay, Arnaud Bonnard, Enora Le Roux, Thomas Gelas, et al.. Feeding disorders in children with oesophageal atresia: a cross-sectional study. Archives of Disease in Childhood, 2021, 107 (1), pp.52-58. ⟨10.1136/archdischild-2020-320609⟩. ⟨hal-03559982⟩