Steroidogenic cell microenvironment and adrenal function in physiological and pathophysiological conditions - Normandie Université Accéder directement au contenu
Article Dans Une Revue Molecular and Cellular Endocrinology Année : 2021

Steroidogenic cell microenvironment and adrenal function in physiological and pathophysiological conditions

Résumé

The human adrenal cortex is a complex organ which is composed of various cell types including not only steroidogenic cells but also mesenchymal cells, immunocompetent cells and neurons. Intermingling of these diverse cell populations favors cell-to-cell communication processes involving local release of numerous bioactive signals such as biogenic amines, cytokines and neuropeptides. The resulting paracrine interactions play an important role in the regulation of adrenocortical cell functions both in physiological and pathophysiological conditions. Especially, recent evidence indicates that adrenocortical cell microenvironment is involved in the pathogenesis of adrenal disorders associated with corticosteroid excess. The paracrine factors involved in these intraadrenal regulatory mechanisms may thus represent valuable targets for future pharmacological treatments of adrenal diseases.
Fichier principal
Vignette du fichier
S0303720721002215.pdf (1.27 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03553308 , version 1 (02-08-2023)

Licence

Paternité - Pas d'utilisation commerciale

Identifiants

Citer

Antoine-Guy Lopez, Céline Duparc, Julien Wils, Alexandre Naccache, Mireille Castanet, et al.. Steroidogenic cell microenvironment and adrenal function in physiological and pathophysiological conditions. Molecular and Cellular Endocrinology, 2021, 535, pp.111377. ⟨10.1016/j.mce.2021.111377⟩. ⟨hal-03553308⟩
56 Consultations
8 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More