Synthesis of 2-aminopyridine Lactones and Studies of Their Antioxidant, Antibacterial and Antifungal Properties

Fadila Salhi , Nawel Cheikh , Didier Villemin (1) , Nathalie Bar (1)

1 LCMT - Laboratoire de chimie moléculaire et thioorganique

In the present work, the synthesis and biological activities of substituted 2-aminopyridine δ-lactone derivatives were achieved. 4,6,6-trimethyl-2-oxo-5,6-dihydro-2H-pyran-3-carbonitrile was synthesised from 4-hydroxy-4-methylpentan-2-one, followed by its transformation in enaminonitrile with DMFDMA. The antioxidant effects of substituted 2-aminopyridine δ-lactone derivatives were evaluated through DPPH assay and revealed a great antioxidant capacity. The antifungal and antibacterial activities were investigated by disc diffusion method against clinical Gram-negative bacteria and against clinical fungi. The study shows moderate to very good antibacterial and antifungal activities for the new substituted 2-aminopyridine δ-lactone derivatives. The 25th International Electronic Conference on Synthetic Organic Chemistry , sciforum-053816 ;doi :10.3390/ecsoc-25-11709

Keywords: 2-aminopyridines; bis-2-aminopyridines; antioxidant; DPPH; radical scavenger; antibacterial activity; antifungical activity

Domains: Chemical Sciences; Organic chemistry; Chemical Sciences; Medicinal Chemistry

Fadila Salhi, Nawel Cheikh, Didier Villemin, Nathalie Bar. Synthesis of 2-aminopyridine Lactones and Studies of Their Antioxidant, Antibacterial and Antifungal Properties. . ⟨hal-03510414⟩