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Synthesis of 2-aminopyridine Lactones and Studies of Their Antioxidant, Antibacterial and Antifungal Properties

Abstract : In the present work, the synthesis and biological activities of substituted 2-aminopyridine δ-lactone derivatives were achieved. 4,6,6-trimethyl-2-oxo-5,6-dihydro-2H-pyran-3-carbonitrile was synthesised from 4-hydroxy-4-methylpentan-2-one, followed by its transformation in enaminonitrile with DMFDMA. The antioxidant effects of substituted 2-aminopyridine δ-lactone derivatives were evaluated through DPPH assay and revealed a great antioxidant capacity. The antifungal and antibacterial activities were investigated by disc diffusion method against clinical Gram-negative bacteria and against clinical fungi. The study shows moderate to very good antibacterial and antifungal activities for the new substituted 2-aminopyridine δ-lactone derivatives. The 25th International Electronic Conference on Synthetic Organic Chemistry , sciforum-053816 ;doi :10.3390/ecsoc-25-11709
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https://hal-normandie-univ.archives-ouvertes.fr/hal-03510414
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Submitted on : Tuesday, January 4, 2022 - 2:51:51 PM
Last modification on : Saturday, June 25, 2022 - 9:57:25 AM

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Fadila Salhi, Nawel Cheikh, Didier Villemin, Nathalie Bar. Synthesis of 2-aminopyridine Lactones and Studies of Their Antioxidant, Antibacterial and Antifungal Properties. . ⟨hal-03510414⟩

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