An Easy and Simple Synthesis of Ricinine and its Analogues

Didier Villemin (1) , Florian Faucher , Nathalie Bar (1) , Zahira Kibou , Noureddine Choukchou-Braham

1 LCMT - Laboratoire de chimie moléculaire et thioorganique

Ricinine is an alkaloid of Ricinus communis displaying numerous biological properties. Ricinidine (1-Methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile) and new N-analogues of Ricinidine were obtained by the reaction of ethyl α-ethoxyethylidenecyanoacetate with various amines. Earlier, the ethyl α-ethoxyethylidenecyanoacetate was easily prepared from ethyl cyanoacetate. Biologically amines as tryptamine and histamine were used in order to introduce a second pharmacophore on the target molecule. ecsoc-25-11676

Keywords: ricinine; alkaloid; pyridinone; ECSOC-25-11676

Domains: Chemical Sciences; Organic chemistry; Chemical Sciences; Medicinal Chemistry

Didier Villemin, Florian Faucher, Nathalie Bar, Zahira Kibou, Noureddine Choukchou-Braham. An Easy and Simple Synthesis of Ricinine and its Analogues. . ⟨hal-03510242⟩