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An Easy and Simple Synthesis of Ricinine and its Analogues

Abstract : Ricinine is an alkaloid of Ricinus communis displaying numerous biological properties. Ricinidine (1-Methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile) and new N-analogues of Ricinidine were obtained by the reaction of ethyl α-ethoxyethylidenecyanoacetate with various amines. Earlier, the ethyl α-ethoxyethylidenecyanoacetate was easily prepared from ethyl cyanoacetate. Biologically amines as tryptamine and histamine were used in order to introduce a second pharmacophore on the target molecule. ecsoc-25-11676
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https://hal-normandie-univ.archives-ouvertes.fr/hal-03510242
Contributor : Didier Villemin Connect in order to contact the contributor
Submitted on : Tuesday, January 4, 2022 - 2:28:00 PM
Last modification on : Tuesday, May 3, 2022 - 3:50:57 AM

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  • HAL Id : hal-03510242, version 1

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Didier Villemin, Florian Faucher, Nathalie Bar, Zahira Kibou, Noureddine Choukchou-Braham. An Easy and Simple Synthesis of Ricinine and its Analogues. . ⟨hal-03510242⟩

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