Organocatalytic enantioselective synthesis of β-amino sulfonic acid derivatives

Emmanuel Deau (1) , Alexandra Le Foll (1) , Clémence Fouache (1) , Emilie Corrot (1) , Laetitia Bailly (1) , Vincent Levacher (1) , Pierric Marchand , Florian Querniard , Laurent Bischoff (1) , Jean-François Brière (1)

1 COBRA - Chimie Organique et Bioorganique : Réactivité et Analyse

An unprecedented enantioselective conjugate addition reaction of sodium bisulfite to various nitrostyrenes occurred upon the influence of a bifunctional amino-thiourea organocatalyst; a strategy that opens a straightforward route to unprotected chiral taurine derivatives thanks to the reduction of the obtained β-nitroethanesulfonic acids into the corresponding amino derivatives.

Domaines: Chimie organique; Catalyse

Emmanuel Deau, Alexandra Le Foll, Clémence Fouache, Emilie Corrot, Laetitia Bailly, et al.. Organocatalytic enantioselective synthesis of β-amino sulfonic acid derivatives. Chemical Communications, 2021, 57, pp.8348 - 8351. ⟨10.1039/D1CC03477D⟩. ⟨hal-03322399⟩