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cfDNA Sequencing: Technological Approaches and Bioinformatic Issues

Abstract : In the era of precision medicine, it is crucial to identify molecular alterations that will guide the therapeutic management of patients. In this context, circulating tumoral DNA (ctDNA) released by the tumor in body fluids, like blood, and carrying its molecular characteristics is becoming a powerful biomarker for non-invasive detection and monitoring of cancer. Major recent technological advances, especially in terms of sequencing, have made possible its analysis, the challenge still being its reliable early detection. Different parameters, from the pre-analytical phase to the choice of sequencing technology and bioinformatic tools can influence the sensitivity of ctDNA detection.
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Contributor : Elodie Bohers Connect in order to contact the contributor
Submitted on : Tuesday, July 6, 2021 - 2:53:11 PM
Last modification on : Friday, March 11, 2022 - 6:14:02 PM

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Elodie Bohers, Pierre-Julien Viailly, Fabrice Jardin. cfDNA Sequencing: Technological Approaches and Bioinformatic Issues. Pharmaceuticals, MDPI, 2021, 14 (6), pp.596. ⟨10.3390/ph14060596⟩. ⟨hal-03279434⟩



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