Multicentric Analysis of the Species Distribution and Antifungal Susceptibility of Cryptic Isolates from Aspergillus Section Fumigati

S. Imbert , A. C Normand , S. Cassaing , F. Gabriel , L. Kristensen , C. Bonnal , L. Lachaud (1, 2) , D. Costa (3) , J. Guitard , L. Hasseine , M. Palous , M. Piarroux , M. Hendrickx , R. Piarroux , A. Fekkar , Costa D Guitard

1 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
2 MIVEGEC - Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle
3 ESCAPE - Epidémiosurveillance de protozooses à transmission alimentaire et vectorielle

ABSTRACT The antifungal susceptibility of Aspergillus cryptic species is poorly known. We assessed 51 isolates, belonging to seven Fumigati cryptic species, by the EUCAST reference method and the concentration gradient strip (CGS) method. Species-specific patterns were observed, with high MICs for azole drugs, except for Aspergillus hiratsukae and Aspergillus tsurutae , and high MICs for amphotericin B for Aspergillus lentulus and Aspergillus udagawae . Essential and categorical agreements between EUCAST and CGS results were between 53.3 and 93.3%.

Keywords: Aspergillus section Fumigati; cryptic species; MALDI-TOF mass spectrometry; azole resistance; Aspergillus thermomutatus; Aspergillus lentulus; antifungal susceptibility testing

Domains: Life Sciences [q-bio]

S. Imbert, A. C Normand, S. Cassaing, F. Gabriel, L. Kristensen, et al.. Multicentric Analysis of the Species Distribution and Antifungal Susceptibility of Cryptic Isolates from Aspergillus Section Fumigati. Antimicrobial Agents and Chemotherapy, 2020, 64 (12), ⟨10.1128/AAC.01374-20⟩. ⟨hal-03238921⟩