Skip to Main content Skip to Navigation
Journal articles

MCR under Microwave Irradiation: Synthesis in Water of New 2-Amino-bis(2-phosphonoacetic) Acids

Abstract : Novel 2-amino bis(2-phosphonoacetic) acids were prepared by microwave irradiation of a mixture of amine, glyoxylic acid and phosphorous acid. The reaction takes place with various amines including primary and secondary amines and polyamines, but this reaction is more sensitive to steric hindrance of amine than the similar Kabachnik–Fields reaction. Amino acids can be also transformed into the expected bis(2-phosphonoacetic) acids, with the exception of tryptophan, which gives a β-carboline product.
Document type :
Journal articles
Complete list of metadata

https://hal-normandie-univ.archives-ouvertes.fr/hal-03225346
Contributor : Didier Villemin <>
Submitted on : Wednesday, May 12, 2021 - 2:12:00 PM
Last modification on : Thursday, May 13, 2021 - 3:37:12 AM
Long-term archiving on: : Friday, August 13, 2021 - 6:36:08 PM

File

organics-02-00009.pdf
Publisher files allowed on an open archive

Identifiers

Citation

Didier Villemin, Bernard Moreau, Nathalie Bar. MCR under Microwave Irradiation: Synthesis in Water of New 2-Amino-bis(2-phosphonoacetic) Acids. Organics, MDPI, 2021, 2 (2), pp.98-106. ⟨10.3390/org2020009⟩. ⟨hal-03225346⟩

Share

Metrics

Record views

53

Files downloads

38