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Globetrotting strangles: the unbridled national and international transmission of Streptococcus equi between horses

Catriona Mitchell 1 Karen Steward 1, 2 Amelia Charbonneau 1, 3 Saoirse Walsh 1, 4 Hayley Wilson 1, 5 John Timoney 6 Ulli Wernery 7 Marina Joseph 7 David Craig 8 Kees van Maanen 9 Annelies Hoogkamer-van Gennep 9 Albertine Leon 10, 11 Lucjan Witkowski 12 Magdalena Rzewuska 12 Ilona Stefańska 12 Monika Żychska 12 Gunther van Loon 13 Ray Cursons 14 Olivia Patty 14 Els Acke 15 James Gilkerson 16 Charles El-Hage 16 Joanne Allen 17 Hiroshi Bannai 17 Yuta Kinoshita 17 Hidekazu Niwa 17 Teótimo Becú 18 John Pringle 19 Bengt Guss 19 Reinhard Böse 20 Yvonne Abbott 21 Lisa Katz 21 Bernadette Leggett 21 Tom Buckley 22 Shlomo Blum 23 Fátima Cruz López 24 Ana Fernández Ros 25 Maria Cristina Marotti Campi 26 Silvia Preziuso 27 Carl Robinson 1 J. Richard Newton 1 Ellen Schofield 1, 5 Ben Brooke 1 Mike Boursnell 1 Nicolas de Brauwere 28 Roxane Kirton 28, 29 Charlotte Barton 30 Khalil Abudahab 31, 32 Ben Taylor 31, 32 Corin Yeats 31, 32 Richard Goater 31, 32 David Aanensen 31, 32 Simon Harris 31, 33 Julian Parkhill 5 Matthew Holden 31, 34 Andrew Waller 1, 35, 19
Abstract : The equine disease strangles, which is characterized by the formation of abscesses in the lymph nodes of the head and neck, is one of the most frequently diagnosed infectious diseases of horses around the world. The causal agent, Streptococcus equi subspecies equi , establishes a persistent infection in approximately 10 % of animals that recover from the acute disease. Such ‘carrier’ animals appear healthy and are rarely identified during routine veterinary examinations pre-purchase or transit, but can transmit S. equi to naïve animals initiating new episodes of disease. Here, we report the analysis and visualization of phylogenomic and epidemiological data for 670 isolates of S. equi recovered from 19 different countries using a new core-genome multilocus sequence typing (cgMLST) web bioresource. Genetic relationships among all 670 S. equi isolates were determined at high resolution, revealing national and international transmission events that drive this endemic disease in horse populations throughout the world. Our data argue for the recognition of the international importance of strangles by the Office International des Épizooties to highlight the health, welfare and economic cost of this disease. The Pathogenwatch cgMLST web bioresource described herein is available for tailored genomic analysis of populations of S. equi and its close relative S. equi subspecies zooepidemicus that are recovered from horses and other animals, including humans, throughout the world. This article contains data hosted by Microreact .
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Submitted on : Wednesday, May 5, 2021 - 5:32:09 PM
Last modification on : Thursday, May 6, 2021 - 10:01:39 AM

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Catriona Mitchell, Karen Steward, Amelia Charbonneau, Saoirse Walsh, Hayley Wilson, et al.. Globetrotting strangles: the unbridled national and international transmission of Streptococcus equi between horses. Microbial Genomics, Society for General Microbiology, 2021, 7 (3), ⟨10.1099/mgen.0.000528⟩. ⟨hal-03218690⟩

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