Determinants of IBD‐related disability: a cross‐sectional survey from the GETAID

Jenny Tannoury (1, 2) , Maria Nachury (3, 4) , Carole Martins (5, 6) , Melanie Serrero (7, 8, 9) , Jerome Filippi (10, 11) , Xavier Roblin (12) , Anne Bourrier (13) , Guillaume Bouguen (14, 15, 16) , Denis Franchimont (17) , Guillaume Savoye (18) , Anthony Buisson (19, 20) , Edouard Louis (21) , Stephane Nancey (22, 23) , Vered Abitbol (24) , Jean-Marie Reimund (25, 26, 27, 28) , Olivier Dewitt (29) , Lucine Vuitton (30) , Nicolas Mathieu (31) , Laurent Peyrin-Biroulet (32, 33) , Cyrielle Gilletta (34) , Matthieu Allez (35) , Stephanie Viennot (36) , Caroline Trang-Poisson (37) , David Laharie (38) , Aurelien Amiot (1, 2) , Jean‐marie Reimund (25, 26, 27, 28)

1 Service de gastro-entérologie [Henri Mondor AP-HP, Créteil]
2 EC2M3 - Early detection of Colon Cancer using Molecular Markers and Microbiota (EA 7375)
3 Hôpital Claude Huriez [Lille]
4 Université de Lille
5 Service de Gastroentérologie [Hôpital Beaujon]
6 UPD7 - Université Paris Diderot - Paris 7
7 CIC - Centre d’Investigation Clinique Marseille Nord
8 Hôpital Nord [CHU - APHM]
9 AMU - Aix Marseille Université
10 CHU Nice - Centre Hospitalier Universitaire de Nice
11 UniCA - Université Côte d'Azur
12 Service de Gastro-entérologie et Hépatologie [CHU Saint-Etienne]
13 CHU Saint-Antoine [AP-HP]
14 Service d'hépato-gastro-entérologie [Rennes] = Gastroenterology [Rennes]
15 CIC - Centre d'Investigation Clinique [Rennes]
16 NuMeCan - Nutrition, Métabolismes et Cancer
17 ULB - Hôpital Erasme [Bruxelles]
18 Service d'Hépato-Gastroentérologie [CHU Rouen]
19 CHU Estaing [Clermont-Ferrand]
20 UCA - Université Clermont Auvergne
21 CHU-Liège - Centre Hospitalier Universitaire de Liège
22 HCL - Hospices Civils de Lyon
23 CIRI - Centre International de Recherche en Infectiologie
24 Service de Gastro-entérologie [CHU Cochin]
25 Hôpital de Hautepierre [Strasbourg]
26 IHU Strasbourg - L'Institut hospitalo-universitaire de Strasbourg
27 IRFAC - Inserm U1113 - Interface de Recherche Fondamentale et Appliquée en Cancérologie
28 FHU ARRIMAGE - Fédération Hospitalo-Universitaire "Digestive and OsteoARticular Remodeling/Inflammation/Immunomodulation/Metabolism in diseased ACEing"
29 Cliniques Universitaires Saint-Luc [Bruxelles]
30 Service de Gastro-Entérologie [CHRU Besançon]
31 CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]
32 NGERE - Nutrition-Génétique et Exposition aux Risques Environnementaux
33 Service d'Hépato-gastro-entérologie [CHRU Nancy]
34 Service de Gastroentérologie et pancréatologie [CHU Toulouse]
35 Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris]
36 Service d'Hépato-Gastro-Enterologie et Nutrition [CHU Caen]
37 CHU Nantes - Centre Hospitalier Universitaire de Nantes
38 Hôpital Haut-Lévêque [CHU Bordeaux]

Summary Background The burden of inflammatory bowel disease (IBD) is rising worldwide. The goal of IBD treatment is to achieve clinical and endoscopic remission but also prevent disability. Aims To identify the predictive factors of disability in a large population of patients with IBD. Patients and methods We conducted a cross‐sectional survey in 42 tertiary centres in France and Belgium. A self‐administered questionnaire was designed to explore patients and their IBD characteristics. IBD‐disk is a validated tool to measure disability in patients with IBD. The IBD‐disk score was then calculated for each patient. Based on a previous study, an overall IBD‐disk score ≥40 was associated with moderate‐to‐severe disability. Results Among the 2011 patients, 1700 were analysed, including 746 (44%) in self‐reported clinical remission and 752 (44.2%) declaring clinical activity. The patient global assessment of global remission was missing in 200 (11.8%) of 1700 patients. Moderate‐to‐severe disability was significantly increased in patients with BMI >25 kg/m 2 (OR = 1.66; 95% CI [1.29‐2.14]), in those having perception of need for a psychotherapist (OR = 2.24; 95% CI [1.79‐3.05]) and social worker (OR = 1.54; 95% CI [1.08‐2.21]). Conversely, male gender (OR = 0.83; 95% CI [0.69‐0.99]), ulcerative colitis (OR = 0.69; 95% CI [0.53‐0.92]), self‐reported clinical remission (OR = 0.59; 95% CI [0.46‐0.77]) and employed or student occupational status (OR = 0.69; 95% CI [0.52‐0.92]) were inversely correlated with disability. Overall, 257 (34.5%) patients who declared being in clinical remission had disability. Conclusion Determinants of IBD‐related disability include IBD‐related factors but also psychological and social factors. This highlights the importance of a multidisciplinary team in the management of patients with IBD.

Domaines: Sciences du Vivant [q-bio]

Jenny Tannoury, Maria Nachury, Carole Martins, Melanie Serrero, Jerome Filippi, et al.. Determinants of IBD‐related disability: a cross‐sectional survey from the GETAID. Alimentary Pharmacology & Therapeutics (Suppl), 2021, 53 (10), pp.1098-1107. ⟨10.1111/apt.16353⟩. ⟨hal-04214710v2⟩