A Combined Study with 18F-FDG and 11C-Methionine Dynamic PET for the Grading of Brain Gliomas.
Résumé
Purpose: Conventional MRI based on contrast enhancement and T2/FLAIR is often not su cient in differentiating grade II from grade III and grade III from grade IV diffuse gliomas. Here we assessed advanced metabolic imaging using two well characterized PET tracers, namely 18 F-FDG and 11 C-Methionine. Methods: In this prospective study, 39 patients were enrolled with diffuse gliomas of grades II, III or IV underwent dynamic [ 18 F]-FDF-PET and [ 11 C]-Methionine. The rst minutes were taken into account Results: The use of 11 C-Methionine provided signi cant differences between the different histologic subgroups with a higher number of parameters than did the use of 18 F-FDG. The most informative parameter is T/Np (T/N at the peak of the rst maximum) with 11 C-Methionine. Conclusion: The study of the rst minute passage of 18 F-FDG and/or 11 C-Methionine through the tumor and healthy tissues in brain gliomas could not only allow improving the identi cation of the different glioma grades, but also to shorten the time spent by the patients under the camera. In case of using one tracer, methionine still would be the best choice. Otherwise, the use of 18 F-FDG and SUVр (SUV at the peak of the rst maximum) would provide results likely comparable to methionine T/N index.
Domaines
Sciences du Vivant [q-bio]
Origine : Fichiers produits par l'(les) auteur(s)