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Complete and Repeated Response of a Metastatic ALK-rearranged Inflammatory Myofibroblastic Tumor to Crizotinib in a Teenage Girl

Abstract : Inflammatory myofibroblastic tumors (IMT) are rare tumors in children and young adults, considered by the World Health Organization to be intermediate malignancies and rarely metastasizing, with the presence of an anaplastic lymphoma kinase rearrangement in about 50% of the cases. We report the case of a teenager who presented with a metastatic aggressive IMT that was life-threatening despite multiple treatments, and which responded repeatedly to anaplastic lymphoma kinase–targeted crizotinib therapy. Crizotinib induced drastic primary tumor regression, which was sufficient to allow surgical resection and to control distant disease. This case shows that crizotinib is a promising therapy in IMT, even in adolescents and young adults.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-03128847
Contributor : Alexis Veyssiere Connect in order to contact the contributor
Submitted on : Tuesday, February 2, 2021 - 2:54:44 PM
Last modification on : Wednesday, March 30, 2022 - 2:42:49 PM

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Jérémie Gaudichon, Corinne Jeanne-Pasquier, Marianna Deparis, Alexis Veyssiere, Maxime Heyndrickx, et al.. Complete and Repeated Response of a Metastatic ALK-rearranged Inflammatory Myofibroblastic Tumor to Crizotinib in a Teenage Girl. Journal of Pediatric Hematology/Oncology, Lippincott, Williams & Wilkins, 2016, 38 (4), pp.308-311. ⟨10.1097/MPH.0000000000000498⟩. ⟨hal-03128847⟩

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