Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice

Elisabet Viayna , Nicolas Coquelle (1) , Monika Cieslikiewicz-Bouet , Pedro Cisternas , Carolina Oliva , Elena Sánchez-López , Miren Ettcheto , Manuela Bartolini , Angela de Simone , Mattia Ricchini , Marisa Rendina , Mégane Pons , Omidreza Firuzi , Belén Pérez , Luciano Saso , Vincenza Andrisano , Florian Nachon , Xavier Brazzolotto , Maria Luisa García , Antoni Camins , Israel Silman , Ludovic Jean (2) , Nibaldo Inestrosa , Jacques-Philippe Colletier (1) , Pierre-Yves Renard , Diego Muñoz-Torrero

1 IBS - UMR 5075 - Institut de biologie structurale
2 COBRA - Chimie Organique et Bioorganique : Réactivité et Analyse

Domains: Chemical Sciences; Chemical Sciences; Organic chemistry; Chemical Sciences; Medicinal Chemistry

Elisabet Viayna, Nicolas Coquelle, Monika Cieslikiewicz-Bouet, Pedro Cisternas, Carolina Oliva, et al.. Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice. Journal of Medicinal Chemistry, 2020, ⟨10.1021/acs.jmedchem.0c01775⟩. ⟨hal-03094189⟩