Comparison of conventional immunosuppressive drugs versus anti-TNF-α agents in non-infectious non-anterior uveitis

Mathilde Leclercq (1) , Vincent Langlois (2) , Nicolas Girszyn (1) , Maëlle Le Besnerais (1, 3) , Ygal Benhamou (3, 1) , Hervé Levesque (3, 1) , Marc Muraine (1) , Julie Gueudry (1, 4)

1 Hôpital Charles Nicolle [Rouen]
2 Hopital Jacques Monod
3 EnVI - Endothélium, valvulopathies et insuffisance cardiaque
4 UNIROUEN - Université de Rouen Normandie

Objective: To compare the efficacy and safety of Disease-modifying antirheumatic drugs (DMARDs) and anti-TNF-α agents in patients with non-infectious non-anterior uveitis. Methods: Single center retrospective study including adult patients with non-infectious intermediate, posterior or pan-uveitis. Outcomes were compared between patients treated with DMARDs or anti-TNF-α agents. The primary outcome was treatment failure or occurrence of serious adverse events. Treatment failure was determined by ophthalmologic criteria. Results: Seventy-three patients were included, mostly female (52%). Among them, 39 were treated with DMARDs and 34 with anti-TNF-α agents. The main uveitis causes were idiopathic (30%), birdshot chorio-retinopathy (25%), sarcoidosis (16%) and Behçet's disease (14%). The primary outcome was observed in 56% of patients treated with anti-TNF-α agents versus 59% of patients treated with DMARDs (p = 0.82). Median time to observe the primary outcome was 16 months (anti-TNF-α group) versus 21 months (p = 0.52). There was no significant difference between the two groups in terms of treatment failure, corticosteroid sparing effect, visual acuity improvement or adverse events. Earlier control of ocular inflammation was achieved with anti-TNF-α agents than with DMARDs (p = 0.006). In relapsing patients, anti-TNF-α agents allowed better corticosteroid sparing (p = 0.06). Conclusion: DMARDs could still be used as first-line therapy for non-infectious non-anterior uveitis after corticosteroid therapy. However, anti-TNF-α agents could be proposed as an alternative in cases of severe inflammation or initial high level of steroid dependency.

Mots clés: Non-infectious non-anterior uveitis; Anti-TNF-α agents; DMARD; Ocular inflammation; Cystoid macular edema

Domaines: Organes des sens; Immunothérapie

Mathilde Leclercq, Vincent Langlois, Nicolas Girszyn, Maëlle Le Besnerais, Ygal Benhamou, et al.. Comparison of conventional immunosuppressive drugs versus anti-TNF-α agents in non-infectious non-anterior uveitis. Journal of Autoimmunity, 2020, 113 (9), pp.102481. ⟨10.1016/j.jaut.2020.102481⟩. ⟨hal-02955618⟩