Equine Asthma: Current Understanding and Future Directions

Laurent Couetil (1) , Jacqueline Cardwell (2) , Renaud Leguillette (3) , Melissa Mazan (4) , Eric Richard (5, 6) , Dorothee Bienzle (7) , Michela Bullone (8) , Vinzenz Gerber (9, 10) , Kathleen Ivester (1) , Jean-Pierre Lavoie (11) , James Martin (12) , Gabriel Moran (13) , Artur Niedźwiedź (14) , Nicola Pusterla (15) , Cyprianna Swiderski (16)

1 College of Veterinary Medicine
2 Department of Pathobiology and Population Sciences
3 University of Calgary
4 Tufts University [Medford]
5 LABÉO - LABÉO, Pôle d’analyses et de recherche de Normandie
6 BIOTARGEN - Biologie, génétique et thérapies ostéoarticulaires et respiratoires
7 University of Guelph
8 UNITO - Università degli studi di Torino = University of Turin
9 UNIBE - Universität Bern / University of Bern
10 ISME - Institut Suisse de Médecine Equine
11 UQAM - Université du Québec à Montréal = University of Québec in Montréal
12 Cancer Research Program, Research Institute of the McGill University Health Center, Montreal, Quebec, Canada
13 Universidad Austral de Chile
14 Wroclaw University of Environmental and Life Sciences
15 UC - University of California
16 Mississippi State University [Mississippi]

The 2019 Havemeyer Workshop brought together researchers and clinicians to discuss the latest information on Equine Asthma and provide future research directions. Current clinical and molecular asthma phenotypes and endotypes in humans were discussed and compared to asthma phenotypes in horses. The role of infectious and non-infectious causes of equine asthma, genetic factors and proposed disease pathophysiology were reviewed. Diagnostic limitations were evident by the limited number of tests and biomarkers available to field practitioners. The participants emphasized the need for more accessible, standardized diagnostics that would help identify specific phenotypes and endotypes in order to create more targeted treatments or management strategies. One important outcome of the workshop was the creation of the Equine Asthma Group that will facilitate communication between veterinary practice and research communities through published and easily accessible guidelines and foster research collaboration.

Mots clés: biomarkers; endotype; heaves; inflammatory airway disease; phenotype; recurrent airway obstruction

Domaines: Médecine vétérinaire et santé animale

Laurent Couetil, Jacqueline Cardwell, Renaud Leguillette, Melissa Mazan, Eric Richard, et al.. Equine Asthma: Current Understanding and Future Directions. Frontiers in Veterinary Science, 2020, 7, pp.450. ⟨10.3389/fvets.2020.00450⟩. ⟨hal-02937788⟩