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Article Dans Une Revue Mendeleev Communications Année : 2020

Temperature cycle induced deracemization

Résumé

The problem of separation and purification of the enantiomers of chiral species is a significant issue in the production of modern chemicals of pharmaceutical, agricultural and food industries. Efficient methods enabling a complete conversion of a racemic mixture into the desired enantiomer would be of great benefit to industry. Temperature cycle induced deracemization (TCID), a process allowing an initially racemic crystal phase of a suspension to be converted into an enantiopure state, combines solution phase racemization of the solute molecules and a series of temperature cycles inducing dissolution and crystal growth. The process first described as a more convenient and scalable alternative to Viedma ripening, has now been successfully tested on a wide range of chiral components that are conglomerate forming and racemizable. This review discusses the origins of TCID, potential mechanisms responsible for the deracemization, and also some related processes.

Domaines

Chimie
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Dates et versions

hal-02914614 , version 1 (12-08-2020)

Identifiants

Citer

Kritsada Intaraboonrod, Tharit Lerdwiriyanupap, Marine Hoquante, Gérard Coquerel, Adrian Flood. Temperature cycle induced deracemization. Mendeleev Communications, 2020, 30 (4), pp.395-405. ⟨10.1016/j.mencom.2020.07.002⟩. ⟨hal-02914614⟩
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