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Bromine–Lithium Exchange on a gem -Dibromoalkene, Part 2: Comparative Performance of Flow Micromixers

Abstract : The influence of the mixer shape on the stereoselectivity was measured for lithium–bromine exchange on a gem-dibromoalkene followed by proton trapping. Sixteen passive mixers with eight different angles (135, 120, and 105° (Y mixers); 90° (T mixer); 75, 60, 45, and 30° (W mixers)) and two internal diameters (500 and 250 μm) associated with a tubular microflow reactor having an internal diameter of 500 μm were used. The 45° W-shaped mixer with a smaller internal diameter gave the best selectivity for the monobrominated E product over a range of flow rates without the usual cryogenic conditions (20 °C). With methyl benzoylformate as the electrophile, the corresponding polyfunctionalized product was obtained in a space-time yield of 81 kg L–1 h–1.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02899306
Contributor : Madeleine Roux-Merlin <>
Submitted on : Wednesday, July 15, 2020 - 9:01:54 AM
Last modification on : Friday, September 4, 2020 - 10:50:04 AM

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Katia Pérez, Baptiste Picard, Daniela Vuluga, Fabrice Burel, Rainier Hreiz, et al.. Bromine–Lithium Exchange on a gem -Dibromoalkene, Part 2: Comparative Performance of Flow Micromixers. Organic Process Research and Development, American Chemical Society, 2020, 24 (5), pp.787-791. ⟨10.1021/acs.oprd.0c00203⟩. ⟨hal-02899306⟩

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