Efficient multicomponent synthesis of 2‑aminopyridines catalysed by basic mesoporous materials

Fatiha Nouali (1) , Zahira Kibou (1) , Bouhadjar Boukoussa (2) , Noureddine Choukchou-Braham (1) , Abdelkader Bengueddach (2) , Didier Villemin (3) , Rachida Hamacha (2)

1 Université de Tlemcen
2 Université d'Oran 1 Ahmed Ben Bella [Oran]
3 LCMT - Laboratoire de chimie moléculaire et thioorganique

An efficient and green procedure for the synthesis of 2-aminopyridines derivatives via four-component reaction of acetophenone, malononitrile, triethoxymethane and different primary amines has been developed using different surfactant-containing mesoporous catalysts. The advantages of this approach are easy operational method, high product yields and reusable catalysts without losing their catalytic activity.

Keywords: Multicomponent reactions; Solvent-free; Mesoporous materials; MCM-41; Catalyst reuse

Domains: Chemical Sciences; Organic chemistry; Chemical Sciences; Catalysis; Chemical Sciences; Material chemistry

Fatiha Nouali, Zahira Kibou, Bouhadjar Boukoussa, Noureddine Choukchou-Braham, Abdelkader Bengueddach, et al.. Efficient multicomponent synthesis of 2‑aminopyridines catalysed by basic mesoporous materials. Research on Chemical Intermediates, 2020, 46, pp.3179-3191. ⟨10.1007/s11164-020-04144-5⟩. ⟨hal-02880243⟩