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Copper-based fluorinated reagents for the synthesis of CF 2 R-containing molecules (R ≠ F)

Abstract : Over the years, the development of new methodologies for the introduction of various fluorinated motifs has gained a significant interest due to the importance of fluorine-containing molecules in the pharmaceutical and agrochemical industries. In a world eager to eco-friendlier tools, the need for innovative methods has been growing. To address these two challenges, copper-based reagents were developed to introduce CF 2 H, CF 2 R F , CF 2 CH 3 , CF 2 PO(OEt) 2 and CF 2 SO 2 Ph motifs on a broad range of substrates. Copper-based fluorinated reagents have the advantage of being inexpensive and generally in situ generated or prepared in a few steps, which make them convenient to use. In this review, an overview of the recent advances made for the synthesis of fluorinated molecules using copper-based fluorinated reagents will be given. 1051
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Submitted on : Friday, May 22, 2020 - 10:15:26 AM
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Louise Ruyet, Tatiana Besset. Copper-based fluorinated reagents for the synthesis of CF 2 R-containing molecules (R ≠ F). Beilstein Journal of Organic Chemistry, Beilstein-Institut, 2020, 16, pp.1051-1065. ⟨10.3762/bjoc.16.92⟩. ⟨hal-02615098⟩

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