An alkaloid, two conjugate sesquiterpenes and a phenylpropanoid from Pachypodanthium confine Engl. and Diels

Hilarion Mathouet (1) , Abdelhakim Elomri (1) , Pedro Lameiras (1) , Adam Daïch (2) , Philippe Vérité (3)

1 COBRA - Chimie Organique et Bioorganique : Réactivité et Analyse
2 URCOM - Unité de Recherche en Chimie Organique et Macromoléculaire
3 ADEN - Appareil Digestif Environnement Nutrition

Two sesquiterpene-trimethoxystyrene conjugates (E)-1-[3′-(4″,8″-dimethylnona-3″,7″-dienyl)cyclohex-3′-enyl]-2,4,5-trimethoxybenzene (1) and (Z)-1-[3′-(4″,8″-dimethylnona-3″,7″-dienyl)cyclohex-3′-enyl]-2,4,5-trimethoxybenzene (2), a phenylpropanoid 1,2,4-trimethoxy-5-(1-methoxy-ethyl)-benzene (3), and an aporphine alkaloid N-acetylpachypodanthine (4), were isolated in addition to several known compounds from cyclohexane, dichloromethane and alkaloid extracts from bark of Pachypodanthium confine. The structures of these compounds were established based on the interpretation of their high resolution NMR (HSQC, HMBC, COSY and NOESY) spectral data.

Domains: Chemical Sciences; Catalysis; Chemical Sciences; Organic chemistry; Chemical Sciences; Medicinal Chemistry

Hilarion Mathouet, Abdelhakim Elomri, Pedro Lameiras, Adam Daïch, Philippe Vérité. An alkaloid, two conjugate sesquiterpenes and a phenylpropanoid from Pachypodanthium confine Engl. and Diels. Phytochemistry, 2007, 68 (13), pp.1813-1818. ⟨10.1016/j.phytochem.2007.04.001⟩. ⟨hal-02564924⟩