Diaryliodoniums Salts as Coupling Partners for Transition-Metal Catalyzed C- and N-Arylation of Heteroarenes

Alexandra Pacheco-Benichou (1) , Thierry Besson (1) , Corinne Fruit (1)

1 COBRA - Chimie Organique et Bioorganique : Réactivité et Analyse

Owing to the pioneering works performed on the metal-catalyzed sp2 C–H arylation of indole and pyrrole by Sanford and Gaunt, N– and C-arylation involving diaryliodonium salts offers an attractive complementary strategy for the late-stage diversification of heteroarenes. The main feature of this expanding methodology is the selective incorporation of structural diversity into complex molecules which usually have several C–H bonds and/or N–H bonds with high tolerance to functional groups and under mild conditions. This review summarizes the main recent achievements reported in transition-metal-catalyzed N– and/or C–H arylation of heteroarenes using acyclic diaryliodonium salts as coupling partners

Domaines: Chimie; Chimie organique

Alexandra Pacheco-Benichou, Thierry Besson, Corinne Fruit. Diaryliodoniums Salts as Coupling Partners for Transition-Metal Catalyzed C- and N-Arylation of Heteroarenes. Catalysts, 2020, 10 (5), pp.483. ⟨10.3390/catal10050483⟩. ⟨hal-02557380⟩