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Pd(0)-Catalyzed Direct Inter- and Intramolecular C–H Functionalization of 4-Carboxyimidazoles

Abstract : The palladium-catalyzed arylation and alkenylation of N-substituted methyl imidazole-4-carboxylates are described through inter- and intramolecular pathways. Both direct C2–H and C5–H arylation and alkenylation proceed under Pd(0)/Cu(I) cooperative catalysis and Pd(0) catalysis, respectively, in low-polarity 1,4-dioxane solvent. The methodology gives access to C2 (hetero)aryl or alkenyl imidazoles as well as innovative C2- and C5-arylated fused imidazoles tricycles with a five- to seven-membered middle ring.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02548986
Contributor : Madeleine Roux-Merlin <>
Submitted on : Tuesday, April 21, 2020 - 10:14:23 AM
Last modification on : Thursday, July 2, 2020 - 3:28:43 AM

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Steven Frippiat, Antoine Peresson, Thibaut Perse, Yvan Ramondenc, Cédric Schneider, et al.. Pd(0)-Catalyzed Direct Inter- and Intramolecular C–H Functionalization of 4-Carboxyimidazoles. SYNLETT, Georg Thieme Verlag, 2020, 31 (10), pp.1015-2021. ⟨10.1055/s-0040-1708003⟩. ⟨hal-02548986⟩

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