Formation of Imidazolones by Ring Closure of α-Isocyanoamides: Exploring New Reactivities

Steven Frippiat (1) , Claire Leterrier (1) , Christine Baudequin (1) , Christophe Hoarau (1) , Laurent Bischoff (1)

1 COBRA - Chimie Organique et Bioorganique : Réactivité et Analyse

Base-mediated ring closure of α,α-disubstituted α-isocyanoamides with further electrophilic trapping has previously been explored, but with limited applications. In this work, we wished to unravel the reactivities of these compounds and, in particular, to allow palladium-catalyzed coupling at the C2 position.

Mots clés: Isocyanides; Imidazolones; Lithium compounds; Palladium catalysis; Coupling

Domaines: Chimie

Steven Frippiat, Claire Leterrier, Christine Baudequin, Christophe Hoarau, Laurent Bischoff. Formation of Imidazolones by Ring Closure of α-Isocyanoamides: Exploring New Reactivities. SYNLETT, 2020, (in press). ⟨10.1055/s-0040-1708015⟩. ⟨hal-02548970⟩