Stereoselective Synthesis of Pyrrolidines from N -Allyl Oxazolidines via Hydrozirconation−Cyclization

Jean-Luc Vasse (1) , Antoine Joosten (1) , Clément Denhez (1) , Jan Szymoniak (1)

1 RSA - Réactions sélectives et applications

A new diastereoselective synthesis of pyrrolidines from readily available chiral N-allyl oxazolidines is presented. The construction of the pyrrolidine ring is achieved via a tandem hydrozirconation−stereoselective Lewis acid mediated cyclization sequence.

Domaines: Chimie

Jean-Luc Vasse, Antoine Joosten, Clément Denhez, Jan Szymoniak. Stereoselective Synthesis of Pyrrolidines from N -Allyl Oxazolidines via Hydrozirconation−Cyclization. Organic Letters, 2005, 7 (22), pp.4887-4889. ⟨10.1021/ol0517776⟩. ⟨hal-02548612⟩