Skip to Main content Skip to Navigation
New interface
Journal articles

Diastereoselective Access to trans -2-Substituted Cyclopentylamines

Abstract : A highly diastereoselective synthesis of trans-2-substituted cyclopentylamines via a tandem hydrozirconation/Lewis acid-mediated cyclization sequence applied to butenyl oxazolidines is described. The method allows an easy preparation of diversely substituted cyclopentylamines which appear to be useful synthetic intermediates. This was further illustrated by the syntheses of (±)-Rodocaine, (±)-trans-pentacin, and enantiomerically enriched trans-cyclopentane-1,2-diamine.
Document type :
Journal articles
Complete list of metadata
Contributor : Madeleine ROUX-MERLIN Connect in order to contact the contributor
Submitted on : Monday, April 20, 2020 - 5:43:36 PM
Last modification on : Friday, August 5, 2022 - 11:22:42 AM



Antoine Joosten, Émilie Lambert, Jean-Luc Vasse, Jan Szymoniak. Diastereoselective Access to trans -2-Substituted Cyclopentylamines. Organic Letters, 2010, 12 (22), pp.5128-5131. ⟨10.1021/ol102038x⟩. ⟨hal-02548596⟩



Record views