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Functionalization of GlucoPyranosides at position 5 by 1,5 C–H insertion of Rh(II)-Carbenes: Dramatic influence of the anomeric configuration

Jana Hammoud 1 Antoine Joosten 1 Thomas Lecourt 1
1 COBRA - Chimie Organique et Bioorganique : Réactivité et Analyse
Abstract : Herein, a C–H bond functionalization approach is reported as a new route towards non-natural glycosides having a quaternary position 5. The development of this transformation furthermore reveals that insertion of Rh(II)-carbenes into the C5–H bond is controlled by remote stereoelectronic effects induced by the axial or equatorial orientation of the aglycone.
Keywords : C-H bond functionalization Rh(II)-carbene Quaternarization Stereoelectronic effects
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02548495
Contributor : Madeleine Roux-Merlin <>
Submitted on : Monday, April 20, 2020 - 5:06:06 PM
Last modification on : Thursday, July 2, 2020 - 3:30:02 AM

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Jana Hammoud, Antoine Joosten, Thomas Lecourt. Functionalization of GlucoPyranosides at position 5 by 1,5 C–H insertion of Rh(II)-Carbenes: Dramatic influence of the anomeric configuration. Carbohydrate Research, Elsevier, 2019, 486, pp.107834. ⟨10.1016/j.carres.2019.107834⟩. ⟨hal-02548495⟩

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