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Pyloric distensibility measurement after gastric surgery: Which surgeries are associated with pylorospasm?

Abstract : Background and study aims History of gastric surgery is found in 10% of patients with gastroparesis, and vagal lesion is often suspected to be the cause of pylorospasm. Recently, pyloric distensibility measurement using the EndoFLIP® system showed that pylorospasm was present in 30%‐50% of gastroparetic patients. Our objective was to assess whether pylorospasm, diagnosed using EndoFLIP® system was observed in three different types of gastric surgeries: antireflux surgery, sleeve gastrectomy, and esophagectomy. Patients and Methods Pyloric distensibility and pressure were measured using the EndoFLIP® system in 43 patients from two centers (18 antireflux surgery, 16 sleeve gastrectomy, and nine esophagectomy) with dyspeptic symptoms after gastric surgery, and in 21 healthy volunteers. Altered pyloric distensibility was defined as distensibility below 10 mm2/mm Hg as previously reported. Results Compared to healthy volunteers (distensibility: 25.2 ± 2.4 mm2/mm Hg; pressure: 9.7 ± 4.4 mm Hg), pyloric distensibility was decreased in 61.1% of patients in the antireflux surgery group (14.5 ± 3.4 mm2/mm Hg; P < .01) and 75.0% of patients in the esophagectomy group (10.8 ± 2.1 mm2/mm Hg; P < .05), while pyloric pressure was only increased in the antireflux surgery group (18.9 ± 2.2 mm Hg; P < .01). Pyloric distensibility and pressure were similar in healthy volunteers and in sleeve gastrectomy (distensibility: 20.3 ± 3.8 mm2/mm Hg; pressure: 15.8 ± 1.6 mm Hg) groups, with decreased pyloric distensibility affecting 18.7% of sleeve gastrectomy patients. Conclusion Antireflux surgery and esophagectomy were associated with pylorospasm although pylorospasm was not found in all patients. Sleeve gastrectomy was not associated with altered pyloric distensibility nor altered pyloric pressure.
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Submitted on : Thursday, April 9, 2020 - 11:41:57 AM
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Charlotte Desprez, Chloé Melchior, Fabien Wuestenberghs, Emmanuel Huet, Alberto Zalar, et al.. Pyloric distensibility measurement after gastric surgery: Which surgeries are associated with pylorospasm?. Neurogastroenterology & Motility, Wiley, 2020, ⟨10.1111/nmo.13790⟩. ⟨hal-02538165⟩



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