A. Groß, C. Hashimoto, H. Sticht, J. Eichler-;-r.-gopalakrishnan, A. I. Frolov et al., Frontiers in Bioengineering and Biotechnology, vol.3, p.9599, 2016.

G. Lelais, D. Seebach, P. Science, ;. Aguilar, A. W. Purcell et al., Methods in Enzymology, vol.76, p.9718, 1366.

. Angew and . Chem, , p.14025, 2018.

E. Juaristi, V. A. Soloshonok, ;. Kudo, A. Miyanaga, and T. Eguchi, Enantioselective Synthesis of ?-Amino Acids, p.1056, 2005.

C. Yuan, R. M. Williams, J. Am, ). A. Nefzi, J. M. Ostresh et al., 38, 4943; c), Journal of Peptide Science, vol.119, issue.103, 1997.

C. Fanter, D. Müller, F. Schepmann, B. Bracher, and . Wünsch, Bioorg. Med. Chem, p.4778, 2017.

J. Ma-;-b, ). B. Weiner, W. Szyma?ski, D. B. Janssen, A. J. Minnaard et al., For review, vol.42, p.4737, 1656.

, For emerging coupling reagents for amide bond formation, see: a), Chem. Rev, vol.116, 2016.

K. Hollanders, B. U. Maes, and S. Ballet, Synthesis, p.2261, 2019.

J. W. Bode, R. M. Fox, K. D. Baucom-;-m, S. Juarez-garcia, J. W. Yu et al., Angew. Chem. Int. Ed, vol.45, p.2104, 1179.

K. Michigami, H. Murakami, T. Nakamura, N. Hayama, and Y. Takemoto, Org. Biomol. Chem, p.2331, 2019.

J. Zhu, Q. Wang, and M. Wang, Multicomponent Reactions in Organic Synthesis, 2014.

C. Berini, M. Sebban, H. Oulyadi, M. Sanselme, V. Levacher et al., 5408?5411; b) A. Le Foll Devaux, For early discovery of the MCR to form racemic isoxazolidin-5-ones from achiral aldehydes and N-oxycarbonyl-hydroxylamines, vol.17, p.3265, 2015.

E. Pair, T. Cadart, V. Levacher, and J. Brière, For reviews on catalytic transformations of alkylidene Meldrum's acids, vol.43, p.1882, 2010.

, For a review on catalytic enantioselective synthese of isoxazolidin-5-ones, see, vol.49, p.2117, 2017.

S. Postikova, T. Tite, V. Levacher, and J. Brière, For rare examples of catalytic enantioselective synthesis (dicomponant) of ?-substituted N-EWG isoxazolidin-5-ones, see: a), Adv. Synth. Catal, vol.355, p.696, 2013.

I. Ibrahem, R. Rios, J. Vesely, G. Zhao, and A. Córdova, For dicomponant but two steps catalytic synthesis of ?-substituted N-EWG isoxazolidin-5-ones, see: a), Chem. Commun, vol.849, 2007.

). A. Pou and A. Moyano, Eur. J. Org. Chem, p.3103, 2013.

). Jiang, H. Gao, and C. ,

C. Ge, Chem. Lett, vol.28, p.471, 2017.

J. Lai, S. Sayalero, A. Ferrali, L. Osorio-planes, F. Bravo et al., Adv. Synth. Catal, vol.360, p.2914, 2018.

, Benzylidene MA is 10 11 time more electrophilic than benzylidene malonate: O. Kaumanns, H. Mayr, J. Org. Chem, vol.73, 2008.

, For a recent example describing the use of a 1,3-diketone that buffer nonaqueous Solutions, Chem. Eur. J, vol.26, p.222, 2020.

, The N-O bond reductive cleavage could be easily achieved on the mixture of diastereoisomers 3a, but it turned out to be much more difficult to separate the two diastereoisomers of the obtained dipeptide 6a on column chromatography. This shows the clear advantage of working with isoxazolidinone 3a whose pure major (S,S)-diastereoisomer could be isolated

, In case of aliphatic aldehydes such valeraldehyde 2b, the catalyzed reaction (optimized conditions) could be performed with more concentrated conditions with only a moderate impact on dr

, contains the supplementary crystallographic data for respectively compounds 3c (minor diastereoisomer), 6a (the two diastereoisomers both originated from major and minor stereoisomers 3a), CCDC 1983122, vol.6, 1983123.

E. Pair, C. Berini, R. Noël, M. Sanselme, V. Levacher et al., For a rare example of enantioselective catalytic C-N bond formation to alkylidene Meldrum's acids, see, Chem. Commun, vol.50, p.10218, 2014.

H. C. Ottenheijm, J. D. Herscheid-;-r.-rani, and C. Granchi, Eur. J. Med. Chem, vol.86, p.505, 1986.