Skip to Main content Skip to Navigation
Journal articles

Organocatalytic Multicomponent Synthesis of α/β‐Dipeptide Derivatives

Abstract : A straightforward multicomponent Knoevenagel‐aza‐Michael‐Cyclocondensation reaction involving readily available hydroxamic acid‐derived from naturally occurring α‐amino acids allows a diversity‐oriented synthesis of novel isoxazolidin‐5‐ones possessing an N ‐protected α‐amino acid pendant with good to high diastereoselectivities thanks to a match effect with a chiral organocatalyst. These diversely substituted heterocycles, easily isolated as a single diastereoisomer, proved to be versatile platforms for the formation of an array of α/β‐dipeptide fragments.
Document type :
Journal articles
Complete list of metadatas

Cited literature [28 references]  Display  Hide  Download

https://hal-normandie-univ.archives-ouvertes.fr/hal-02523950
Contributor : Jean-François Brière <>
Submitted on : Friday, August 21, 2020 - 11:08:06 AM
Last modification on : Thursday, September 17, 2020 - 9:08:28 AM

File

ChemEurJ2020.pdf
Files produced by the author(s)

Identifiers

Citation

Thomas Martzel, Julien Annibaletto, Pierre Millet, Etienne Pair, Morgane Sanselme, et al.. Organocatalytic Multicomponent Synthesis of α/β‐Dipeptide Derivatives. Chemistry - A European Journal, Wiley-VCH Verlag, 2020, 26, pp.8541. ⟨10.1002/chem.202001214⟩. ⟨hal-02523950⟩

Share

Metrics

Record views

141

Files downloads

17